Skin contamination by radiopharmaceuticals and decontamination strategies
The aim of the present study was to evaluate the percutaneous penetration of five common radiopharmaceuticals ( 99mTc, 67Ga, 125I, 111In and 51Cr) and to evaluate the effect of decontamination by a detergent solution dedicated to hospital institutions for that purpose. The skin kinetic profiles were...
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| Veröffentlicht in: | International journal of pharmaceutics 2010-12, Vol.402 (1), p.44-49 |
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| creator | Bolzinger, M.A. Bolot, C. Galy, G. Chabanel, A. Pelletier, J. Briançon, S. |
| description | The aim of the present study was to evaluate the percutaneous penetration of five common radiopharmaceuticals (
99mTc,
67Ga,
125I,
111In and
51Cr) and to evaluate the effect of decontamination by a detergent solution dedicated to hospital institutions for that purpose. The skin kinetic profiles were established by using the
in vitro Franz cell method over 24
h. The skin distribution in each skin layer was quantified after 6
h exposure time and the efficacy of the detergent solution to remove radionuclides was evaluated also after 6
h. The most striking result was the repartition into two classes of kinetic profiles:
125I and
99mTc permeated quickly (∼60% of applied activity after 24
h) while the 3 other radionuclides permeated slowly (from ∼2.75% for
67Ga to ∼10% of applied activity for
111In). The lag times, i.e. the time necessary to cross the skin varied from 20
min for
99mTc to 5
h for
51Cr, which accumulated in skin compartments. Skin washings with the detergent solution were particularly efficient for this radionuclide, contrary to the others for which the washing procedure should be applied earlier. The permeation of ions was dependent on their chemical and physical forms and on their salting-in or salting-out effects (coordination state and Hofmeister series). |
| doi_str_mv | 10.1016/j.ijpharm.2010.09.027 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01943127v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378517310007283</els_id><sourcerecordid>879469804</sourcerecordid><originalsourceid>FETCH-LOGICAL-c460t-c4865496322e3c56b50d84f1a43da157405772ad5b67eaecceca540dc34ad8673</originalsourceid><addsrcrecordid>eNqFkU1rGzEQhkVpaZy0PyFlLyXkYGf0rT2VENomYMgh7VmMpXEi17vrSutA_n3l2E3pKSAkGJ4ZDe_D2CmHGQduLlaztNo8YO5mAmoN2hkI-4ZNuLNyKpU1b9kEpHVTza08YselrADACC7fsyMBzjkFasJu7n6lvglDP2KXehzT0DeLpyZjTMPzeAy0HVPAdWmwj02k_9kyZhzpPlH5wN4tK0UfD-8J-_nt64-r6-n89vvN1eV8GpSBsd7OaNUaKQTJoM1CQ3RqyVHJiFxbBdpagVEvjCWkECigVhCDVBidsfKEne_nPuDab3LqMD_5AZO_vpz7XQ14qyQX9pFX9mzPbvLwe0tl9F0qgdZr7GnYFu9sq0zrQL1K2ratpyZfSb0nQx5KybR8WYKD36nxK39Q43dqPLS-qql9nw4_bBcdxZeuvy4q8PkAYKl5LzP2IZV_nFTKaSsq92XPUU35MVH2JSTqA8WUKYw-DumVVf4AznauzQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>799799101</pqid></control><display><type>article</type><title>Skin contamination by radiopharmaceuticals and decontamination strategies</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Bolzinger, M.A. ; Bolot, C. ; Galy, G. ; Chabanel, A. ; Pelletier, J. ; Briançon, S.</creator><creatorcontrib>Bolzinger, M.A. ; Bolot, C. ; Galy, G. ; Chabanel, A. ; Pelletier, J. ; Briançon, S.</creatorcontrib><description>The aim of the present study was to evaluate the percutaneous penetration of five common radiopharmaceuticals (
99mTc,
67Ga,
125I,
111In and
51Cr) and to evaluate the effect of decontamination by a detergent solution dedicated to hospital institutions for that purpose. The skin kinetic profiles were established by using the
in vitro Franz cell method over 24
h. The skin distribution in each skin layer was quantified after 6
h exposure time and the efficacy of the detergent solution to remove radionuclides was evaluated also after 6
h. The most striking result was the repartition into two classes of kinetic profiles:
125I and
99mTc permeated quickly (∼60% of applied activity after 24
h) while the 3 other radionuclides permeated slowly (from ∼2.75% for
67Ga to ∼10% of applied activity for
111In). The lag times, i.e. the time necessary to cross the skin varied from 20
min for
99mTc to 5
h for
51Cr, which accumulated in skin compartments. Skin washings with the detergent solution were particularly efficient for this radionuclide, contrary to the others for which the washing procedure should be applied earlier. The permeation of ions was dependent on their chemical and physical forms and on their salting-in or salting-out effects (coordination state and Hofmeister series).</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2010.09.027</identifier><identifier>PMID: 20888404</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Chemical and Process Engineering ; Decontamination - methods ; Detergents - pharmacology ; Engineering Sciences ; Female ; Franz cells ; General pharmacology ; Hofmeister series ; In Vitro Techniques ; Life Sciences ; Male ; Medical sciences ; Percutaneous absorption ; Permeability ; Pharmaceutical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Radiopharmaceuticals ; Radiopharmaceuticals - pharmacokinetics ; Skin - metabolism ; Skin Absorption ; Skin decontamination ; Swine ; Time Factors</subject><ispartof>International journal of pharmaceutics, 2010-12, Vol.402 (1), p.44-49</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-c4865496322e3c56b50d84f1a43da157405772ad5b67eaecceca540dc34ad8673</citedby><orcidid>0000-0001-9730-7567 ; 0000-0001-7997-0410 ; 0000-0003-2192-9444</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2010.09.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23448572$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20888404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01943127$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bolzinger, M.A.</creatorcontrib><creatorcontrib>Bolot, C.</creatorcontrib><creatorcontrib>Galy, G.</creatorcontrib><creatorcontrib>Chabanel, A.</creatorcontrib><creatorcontrib>Pelletier, J.</creatorcontrib><creatorcontrib>Briançon, S.</creatorcontrib><title>Skin contamination by radiopharmaceuticals and decontamination strategies</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>The aim of the present study was to evaluate the percutaneous penetration of five common radiopharmaceuticals (
99mTc,
67Ga,
125I,
111In and
51Cr) and to evaluate the effect of decontamination by a detergent solution dedicated to hospital institutions for that purpose. The skin kinetic profiles were established by using the
in vitro Franz cell method over 24
h. The skin distribution in each skin layer was quantified after 6
h exposure time and the efficacy of the detergent solution to remove radionuclides was evaluated also after 6
h. The most striking result was the repartition into two classes of kinetic profiles:
125I and
99mTc permeated quickly (∼60% of applied activity after 24
h) while the 3 other radionuclides permeated slowly (from ∼2.75% for
67Ga to ∼10% of applied activity for
111In). The lag times, i.e. the time necessary to cross the skin varied from 20
min for
99mTc to 5
h for
51Cr, which accumulated in skin compartments. Skin washings with the detergent solution were particularly efficient for this radionuclide, contrary to the others for which the washing procedure should be applied earlier. The permeation of ions was dependent on their chemical and physical forms and on their salting-in or salting-out effects (coordination state and Hofmeister series).</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and Process Engineering</subject><subject>Decontamination - methods</subject><subject>Detergents - pharmacology</subject><subject>Engineering Sciences</subject><subject>Female</subject><subject>Franz cells</subject><subject>General pharmacology</subject><subject>Hofmeister series</subject><subject>In Vitro Techniques</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Percutaneous absorption</subject><subject>Permeability</subject><subject>Pharmaceutical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiopharmaceuticals</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Skin - metabolism</subject><subject>Skin Absorption</subject><subject>Skin decontamination</subject><subject>Swine</subject><subject>Time Factors</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVpaZy0PyFlLyXkYGf0rT2VENomYMgh7VmMpXEi17vrSutA_n3l2E3pKSAkGJ4ZDe_D2CmHGQduLlaztNo8YO5mAmoN2hkI-4ZNuLNyKpU1b9kEpHVTza08YselrADACC7fsyMBzjkFasJu7n6lvglDP2KXehzT0DeLpyZjTMPzeAy0HVPAdWmwj02k_9kyZhzpPlH5wN4tK0UfD-8J-_nt64-r6-n89vvN1eV8GpSBsd7OaNUaKQTJoM1CQ3RqyVHJiFxbBdpagVEvjCWkECigVhCDVBidsfKEne_nPuDab3LqMD_5AZO_vpz7XQ14qyQX9pFX9mzPbvLwe0tl9F0qgdZr7GnYFu9sq0zrQL1K2ratpyZfSb0nQx5KybR8WYKD36nxK39Q43dqPLS-qql9nw4_bBcdxZeuvy4q8PkAYKl5LzP2IZV_nFTKaSsq92XPUU35MVH2JSTqA8WUKYw-DumVVf4AznauzQ</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Bolzinger, M.A.</creator><creator>Bolot, C.</creator><creator>Galy, G.</creator><creator>Chabanel, A.</creator><creator>Pelletier, J.</creator><creator>Briançon, S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9730-7567</orcidid><orcidid>https://orcid.org/0000-0001-7997-0410</orcidid><orcidid>https://orcid.org/0000-0003-2192-9444</orcidid></search><sort><creationdate>20101215</creationdate><title>Skin contamination by radiopharmaceuticals and decontamination strategies</title><author>Bolzinger, M.A. ; Bolot, C. ; Galy, G. ; Chabanel, A. ; Pelletier, J. ; Briançon, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-c4865496322e3c56b50d84f1a43da157405772ad5b67eaecceca540dc34ad8673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and Process Engineering</topic><topic>Decontamination - methods</topic><topic>Detergents - pharmacology</topic><topic>Engineering Sciences</topic><topic>Female</topic><topic>Franz cells</topic><topic>General pharmacology</topic><topic>Hofmeister series</topic><topic>In Vitro Techniques</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Percutaneous absorption</topic><topic>Permeability</topic><topic>Pharmaceutical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Radiopharmaceuticals</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Skin - metabolism</topic><topic>Skin Absorption</topic><topic>Skin decontamination</topic><topic>Swine</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bolzinger, M.A.</creatorcontrib><creatorcontrib>Bolot, C.</creatorcontrib><creatorcontrib>Galy, G.</creatorcontrib><creatorcontrib>Chabanel, A.</creatorcontrib><creatorcontrib>Pelletier, J.</creatorcontrib><creatorcontrib>Briançon, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bolzinger, M.A.</au><au>Bolot, C.</au><au>Galy, G.</au><au>Chabanel, A.</au><au>Pelletier, J.</au><au>Briançon, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin contamination by radiopharmaceuticals and decontamination strategies</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>402</volume><issue>1</issue><spage>44</spage><epage>49</epage><pages>44-49</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>The aim of the present study was to evaluate the percutaneous penetration of five common radiopharmaceuticals (
99mTc,
67Ga,
125I,
111In and
51Cr) and to evaluate the effect of decontamination by a detergent solution dedicated to hospital institutions for that purpose. The skin kinetic profiles were established by using the
in vitro Franz cell method over 24
h. The skin distribution in each skin layer was quantified after 6
h exposure time and the efficacy of the detergent solution to remove radionuclides was evaluated also after 6
h. The most striking result was the repartition into two classes of kinetic profiles:
125I and
99mTc permeated quickly (∼60% of applied activity after 24
h) while the 3 other radionuclides permeated slowly (from ∼2.75% for
67Ga to ∼10% of applied activity for
111In). The lag times, i.e. the time necessary to cross the skin varied from 20
min for
99mTc to 5
h for
51Cr, which accumulated in skin compartments. Skin washings with the detergent solution were particularly efficient for this radionuclide, contrary to the others for which the washing procedure should be applied earlier. The permeation of ions was dependent on their chemical and physical forms and on their salting-in or salting-out effects (coordination state and Hofmeister series).</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20888404</pmid><doi>10.1016/j.ijpharm.2010.09.027</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9730-7567</orcidid><orcidid>https://orcid.org/0000-0001-7997-0410</orcidid><orcidid>https://orcid.org/0000-0003-2192-9444</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2010-12, Vol.402 (1), p.44-49 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01943127v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Chemical and Process Engineering Decontamination - methods Detergents - pharmacology Engineering Sciences Female Franz cells General pharmacology Hofmeister series In Vitro Techniques Life Sciences Male Medical sciences Percutaneous absorption Permeability Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Radiopharmaceuticals Radiopharmaceuticals - pharmacokinetics Skin - metabolism Skin Absorption Skin decontamination Swine Time Factors |
| title | Skin contamination by radiopharmaceuticals and decontamination strategies |
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