Modeling and simulation of organophosphate-induced neurotoxicity: Prediction and validation by experimental studies

•A novel in silico model of Organophosphorus (OP)-induced neuronal toxicity is set up.•This model enables predicting effect of drugs on OP-induced neuronal hyperexcitability.•The predicted effects of atropine, memantine, their combination are validated in vivo.•The use of the in silico modeling earl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurotoxicology (Park Forest South) 2016-05, Vol.54, p.140-152
Hauptverfasser:	Greget, Renaud, Dadak, Selma, Barbier, Laure, Lauga, Fabien, Linossier-Pierre, Sandra, Pernot, Fabien, Legendre, Arnaud, Ambert, Nicolas, Bouteiller, Jean-Marie, Dorandeu, Frédéric, Bischoff, Serge, Baudry, Michel, Fagni, Laurent, Moussaoui, Saliha
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl- and/or butyryl-cholinesterase Acetylcholine Acetylcholinesterase - metabolism Animals Brain Waves - drug effects Cholinesterase Reactivators - pharmacology Computer Simulation Disease Models, Animal Enzyme Inhibitors - therapeutic use Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Hippocampus - drug effects Hippocampus - metabolism Life Sciences Male Memantine - pharmacology Membrane Potentials - drug effects Mice Models, Neurological N-Methyl-d-aspartate Neurons - drug effects Neurotoxicity Syndromes - drug therapy Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - pathology Neurotoxicity Syndromes - physiopathology Organophosphates - toxicity Organophosphorus Oximes - pharmacology Paraoxon Paraoxon - toxicity Pyridinium Compounds - pharmacology γ-Aminobutyric acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!