Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle-Wells syndrome and neonatal-onset multiple-system inflammatory disease. Cryopyrin (also called Nalp3), the product of CIAS1, is a member of the NOD-LRR protein family that has...

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Veröffentlicht in:	Nature 2006-03, Vol.440 (7081), p.233-236
Hauptverfasser:	Núñez, Gabriel, Kanneganti, Thirumala-Devi, Özören, Nesrin, Body-Malapel, Mathilde, Amer, Amal, Park, Jong-Hwan, Franchi, Luigi, Whitfield, Joel, Barchet, Winfried, Colonna, Marco, Vandenabeele, Peter, Bertin, John, Coyle, Anthony, Grant, Ethan P, Akira, Shizuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Aminoquinolines - pharmacology Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Apoptosis Regulatory Proteins Autoimmune diseases Bacteria Biological and medical sciences CARD Signaling Adaptor Proteins Carrier Proteins - genetics Carrier Proteins - metabolism Caspase 1 - metabolism Cells, Cultured Cytoskeletal Proteins - deficiency Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Enzyme Activation - drug effects Female Fundamental and applied biological sciences. Psychology Gene expression Humanities and Social Sciences Imidazoles - pharmacology Immunology Inflammation Inflammation - chemically induced Inflammation - immunology Inflammation - metabolism Interleukin-1 - immunology Interleukin-1 - metabolism Interleukin-1 - secretion Interleukin-18 - immunology Interleukin-18 - metabolism Interleukin-18 - secretion Legionella pneumophila - genetics Legionella pneumophila - immunology letter Life Sciences Listeria monocytogenes - genetics Listeria monocytogenes - immunology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - microbiology Male Mice Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology multidisciplinary Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Mutation Myeloid Differentiation Factor 88 NF-kappa B - metabolism NLR Family, Pyrin Domain-Containing 3 Protein Ribonucleic acid RNA RNA, Bacterial - genetics RNA, Bacterial - immunology RNA, Bacterial - pharmacology Science Science (multidisciplinary) Toll-Like Receptors - agonists Toll-Like Receptors - deficiency Toll-Like Receptors - genetics Toll-Like Receptors - immunology
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