The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner
The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, the underlying mechanisms remain unclear. Here we conditionally inactivated EcR by RNA interference or expression of domi...
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| Veröffentlicht in: | Mechanisms of ageing and development 2009-08, Vol.130 (8), p.547-552 |
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| creator | Tricoire, Hervé Battisti, Valentine Trannoy, Séverine Lasbleiz, Christelle Pret, Anne-Marie Monnier, Véronique |
| description | The steroid hormone ecdysone influences Drosophila lifespan. Longevity is extended in mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, the underlying mechanisms remain unclear. Here we conditionally inactivated EcR by RNA interference or expression of dominant negative forms, using the RU486 inducible system. A mild ubiquitous inactivation of EcR during adulthood was sufficient to slow the aging of male flies, whereas a stronger EcR inactivation decreased longevity. Surprisingly, ubiquitous inactivation of EcR strongly decreased female lifespan. This deleterious effect was suppressed in sterile
ovo
D1
mutant females, suggesting that EcR represses a negative signal for lifespan produced in ovaries. These results reveal a complex adult and sex-specific control of lifespan by steroid signalling in Drosophila. |
| doi_str_mv | 10.1016/j.mad.2009.05.004 |
| format | Article |
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ovo
D1
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ovo
D1
mutant females, suggesting that EcR represses a negative signal for lifespan produced in ovaries. These results reveal a complex adult and sex-specific control of lifespan by steroid signalling in Drosophila.</description><subject>Aging</subject><subject>Animal biology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Drosophila</subject><subject>Drosophila - physiology</subject><subject>Ecdysone</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Genes, Dominant</subject><subject>Life Sciences</subject><subject>Longevity</subject><subject>Male</subject><subject>Mifepristone - pharmacology</subject><subject>Models, Biological</subject><subject>Nuclear receptor</subject><subject>Receptors, Steroid - metabolism</subject><subject>Receptors, Steroid - physiology</subject><subject>RNA Interference</subject><subject>Sex Factors</subject><subject>Signal Transduction</subject><subject>Steroid</subject><subject>Steroids - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6A7xILgoeuq18dLqDp2VdXWFAkPUcMkm1k6G70ybdi_vvzTDDetNTQvFU8fI-hLxmUDNg6sOhHq2vOYCuoakB5BOyYV3LK8WZeko2ZdJWSrTygrzI-QAATHL1nFwwLTulGWxIvNsjzQumGDzdxzTGCWlCh_MSE71x32kfJhwe6Bj9OtgFM_2UYo7zPgyWDqHHPNuJ-jWF6Se1hVn2MXoaJmppxt9VntGFPjg62mnC9JI86-2Q8dX5vSQ_Pt_cXd9W229fvl5fbSvXML5UApjrwAmhPde71imNrUCEne97JWUnBACyprRgbce1baRsJeNQPl5rwcUleX-6u7eDmVMYbXow0QZze7U1xxkwLaBT8p4V9t2JnVP8tWJezBiyw2GwE8Y1G9U2nIOC_4IcWuAgRAHZCXSlq5ywf4zAwBzVmYMp6sxRnYHGFFFl5835-Lob0f_dOLsqwNszYLOzQ5_s5EJ-5DjrmCo5C_fxxGHp9z5gMtkFnBz6UMQuxsfwjxh_AEIatQY</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Tricoire, Hervé</creator><creator>Battisti, Valentine</creator><creator>Trannoy, Séverine</creator><creator>Lasbleiz, Christelle</creator><creator>Pret, Anne-Marie</creator><creator>Monnier, Véronique</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TM</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9404-5282</orcidid><orcidid>https://orcid.org/0000-0003-3041-7141</orcidid><orcidid>https://orcid.org/0000-0002-5059-9846</orcidid></search><sort><creationdate>20090801</creationdate><title>The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner</title><author>Tricoire, Hervé ; Battisti, Valentine ; Trannoy, Séverine ; Lasbleiz, Christelle ; Pret, Anne-Marie ; Monnier, Véronique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-301c80c339d29b7c69e73ee0bdff64483300e15101aa829a54474120a54d99323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aging</topic><topic>Animal biology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Development. Metamorphosis. Moult. Ageing</topic><topic>Drosophila</topic><topic>Drosophila - physiology</topic><topic>Ecdysone</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Longevity is extended in mutants deficient for ecdysone synthesis or mutants of the ecdysone receptor (EcR). However, the underlying mechanisms remain unclear. Here we conditionally inactivated EcR by RNA interference or expression of dominant negative forms, using the RU486 inducible system. A mild ubiquitous inactivation of EcR during adulthood was sufficient to slow the aging of male flies, whereas a stronger EcR inactivation decreased longevity. Surprisingly, ubiquitous inactivation of EcR strongly decreased female lifespan. This deleterious effect was suppressed in sterile
ovo
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| ispartof | Mechanisms of ageing and development, 2009-08, Vol.130 (8), p.547-552 |
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| subjects | Aging Animal biology Animals Biological and medical sciences Development. Metamorphosis. Moult. Ageing Drosophila Drosophila - physiology Ecdysone Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes, Dominant Life Sciences Longevity Male Mifepristone - pharmacology Models, Biological Nuclear receptor Receptors, Steroid - metabolism Receptors, Steroid - physiology RNA Interference Sex Factors Signal Transduction Steroid Steroids - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner |
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