Interest of new alkylsulfonylhydrazide-type compound in the treatment of alcohol use disorders

Rationale Recent preclinical research suggested that histone deacetylase inhibitors (HDACIs) and specifically class I HDAC selective inhibitors might be useful to treat alcohol use disorders (AUDs). Objective The objective of this study was to find a new inhibitor of the HDAC-1 isoenzyme and to test...

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Veröffentlicht in:	Psychopharmacology 2018-06, Vol.235 (6), p.1835-1844
Hauptverfasser:	Jeanblanc, Jérôme, Bourguet, Erika, Sketriené, Diana, Gonzalez, Céline, Moroy, Gautier, Legastelois, Rémi, Létévé, Mathieu, Trussardi-Régnier, Aurélie, Naassila, Mickaël
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol use Alcohol-related disorders Alcohols Amygdala Animal biology Ashes Biomedical and Life Sciences Biomedicine Care and treatment Chemical Sciences Cognitive science Drug self-administration Enzymes Ethanol Histone deacetylase Inhibitors Life Sciences Microinjection Motivation Neuroscience Neurosciences Operant conditioning Organic chemistry Organic compounds Original Investigation Pharmacology/Toxicology Physiological aspects Psychiatry Rats Sulfur compounds Zinc
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