Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours
Biallelic NF2 gene inactivation is frequently found in human malignant mesothelioma. In order to assess whether NF2 hemizygosity may enhance susceptibility to asbestos fibres, we investigated the Nf2 status in mesothelioma developed in mice presenting a heterozygous mutation of the Nf2 gene ( Nf2 KO...
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| Veröffentlicht in: | Oncogene 2003-06, Vol.22 (24), p.3799-3805 |
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| creator | Fleury-Feith, Jocelyne Lecomte, Céline Renier, Annie Matrat, Mireille Kheuang, Laurence Abramowski, Vincent Levy, Françoise Janin, Anne Giovannini, Marco Jaurand, Marie-Claude |
| description | Biallelic
NF2
gene inactivation is frequently found in human malignant mesothelioma. In order to assess whether
NF2
hemizygosity may enhance susceptibility to asbestos fibres, we investigated the
Nf2
status in mesothelioma developed in mice presenting a heterozygous mutation of the
Nf2
gene (
Nf2
KO3/+
), after intraperitoneal inoculation of crocidolite fibres. Asbestos-exposed
Nf2
KO3/+
mice developed tumoural ascites and mesothelioma at a higher frequency than their wild-type (WT) counterparts (
P |
| doi_str_mv | 10.1038/sj.onc.1206593 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01928405v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A189218192</galeid><sourcerecordid>A189218192</sourcerecordid><originalsourceid>FETCH-LOGICAL-c548t-54d7028c1563caea25b966ab3681746967bb490486c35667c122d5dbbb7b6f793</originalsourceid><addsrcrecordid>eNp1ks-LEzEUxwdR3Lp69SiDouBhukkmySTHsqgVil70HJJMppsyndS8mZX61_uGFguySw4hL5_345t8i-I1JUtKanUDu2Ua_JIyIoWunxQLyhtZCaH502JBtCCVZjW7Kl4A7AghjSbseXFFmSKMqWZRdOuwj3-O2wRxPJapK791rIxQWoDkox1DW_6O410ZB5-DBTzCBD4cxuhiP6eMCVkXYExQxaGdPCKHkOOYhmD7cpz2acrwsnjW2R7Cq_N-Xfz8_OnH7brafP_y9Xa1qbzgaqwEbxvClKdC1t4Gy4TTUlpXS0UbLrVsnOOacCV9LaRsPGWsFa1zrnGya3R9XXw81b2zvTnkuLf5aJKNZr3amDlGqGaKE3FPkf1wYg85_ZpQgdlHlNb3dghpAkOVIjUnBMF3_4E71DSgDsMkpzXTmnOk3j5KsQYLUSoupba2DyYOXRqz9XNfs6JKM6pwPqSWD1C4Wvwsjw_bRYw_lOBzAsih-6edEjP7xMDOoE_M2SeY8OY87OT2ob3gZ2Mg8P4MWPC277IdfIQLx5WgRM5vc3PiAK-GbcgX1Y-0_guWjNM9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>227340115</pqid></control><display><type>article</type><title>Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours</title><source>MEDLINE</source><source>Nature Journals Online</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Fleury-Feith, Jocelyne ; Lecomte, Céline ; Renier, Annie ; Matrat, Mireille ; Kheuang, Laurence ; Abramowski, Vincent ; Levy, Françoise ; Janin, Anne ; Giovannini, Marco ; Jaurand, Marie-Claude</creator><creatorcontrib>Fleury-Feith, Jocelyne ; Lecomte, Céline ; Renier, Annie ; Matrat, Mireille ; Kheuang, Laurence ; Abramowski, Vincent ; Levy, Françoise ; Janin, Anne ; Giovannini, Marco ; Jaurand, Marie-Claude</creatorcontrib><description>Biallelic
NF2
gene inactivation is frequently found in human malignant mesothelioma. In order to assess whether
NF2
hemizygosity may enhance susceptibility to asbestos fibres, we investigated the
Nf2
status in mesothelioma developed in mice presenting a heterozygous mutation of the
Nf2
gene (
Nf2
KO3/+
), after intraperitoneal inoculation of crocidolite fibres. Asbestos-exposed
Nf2
KO3/+
mice developed tumoural ascites and mesothelioma at a higher frequency than their wild-type (WT) counterparts (
P
<0.05). Six out of seven mesothelioma cell lines established from neoplastic ascitic fluids of
Nf2
KO3/+
mice exhibited loss of the WT
Nf2
allele and no neurofibromatosis type 2 protein expression was found in these cells. The results show the importance of the
NF2
gene in mesothelial oncogenesis, the potential association of asbestos exposure and tumour suppressor gene inactivation, and suggest that
NF2
gene mutation may be a susceptibility factor to asbestos.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1206593</identifier><identifier>PMID: 12802287</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Apoptosis ; Asbestos ; Asbestos, Crocidolite - toxicity ; Ascites ; Biochemistry, Molecular Biology ; Biodiversity and Ecology ; Biological and medical sciences ; Cell Biology ; Cell differentiation, maturation, development, hematopoiesis ; Cell growth ; Cell physiology ; Crocidolite ; Ecology, environment ; Ecosystems ; Ecotoxicology ; Environmental Sciences ; Fibers ; Fundamental and applied biological sciences. Psychology ; Gastric cancer ; Genes, Neurofibromatosis 2 ; Genetic Predisposition to Disease ; Genomics ; Global Changes ; Health ; Hemizygosity ; Human Genetics ; Inoculation ; Internal Medicine ; Life Sciences ; Medicine ; Medicine & Public Health ; Mesothelioma ; Mesothelioma - genetics ; Mice ; Mice, Nude ; Molecular and cellular biology ; Molecular biology ; Mutation ; Neurofibromatosis ; Neurofibromatosis 2 ; Neurofibromin 2 ; oncogenomics ; Oncology ; Peritoneal Neoplasms - genetics ; Peritoneal Neoplasms - pathology ; Point mutation ; Reverse Transcriptase Polymerase Chain Reaction ; Signal transduction ; Susceptibility ; Toxicology ; Tumor suppressor genes ; Tumorigenesis ; Tumors</subject><ispartof>Oncogene, 2003-06, Vol.22 (24), p.3799-3805</ispartof><rights>Springer Nature Limited 2003</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 12, 2003</rights><rights>Nature Publishing Group 2003.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-54d7028c1563caea25b966ab3681746967bb490486c35667c122d5dbbb7b6f793</citedby><cites>FETCH-LOGICAL-c548t-54d7028c1563caea25b966ab3681746967bb490486c35667c122d5dbbb7b6f793</cites><orcidid>0000-0002-2461-7473</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.onc.1206593$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.onc.1206593$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14851060$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12802287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01928405$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Fleury-Feith, Jocelyne</creatorcontrib><creatorcontrib>Lecomte, Céline</creatorcontrib><creatorcontrib>Renier, Annie</creatorcontrib><creatorcontrib>Matrat, Mireille</creatorcontrib><creatorcontrib>Kheuang, Laurence</creatorcontrib><creatorcontrib>Abramowski, Vincent</creatorcontrib><creatorcontrib>Levy, Françoise</creatorcontrib><creatorcontrib>Janin, Anne</creatorcontrib><creatorcontrib>Giovannini, Marco</creatorcontrib><creatorcontrib>Jaurand, Marie-Claude</creatorcontrib><title>Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Biallelic
NF2
gene inactivation is frequently found in human malignant mesothelioma. In order to assess whether
NF2
hemizygosity may enhance susceptibility to asbestos fibres, we investigated the
Nf2
status in mesothelioma developed in mice presenting a heterozygous mutation of the
Nf2
gene (
Nf2
KO3/+
), after intraperitoneal inoculation of crocidolite fibres. Asbestos-exposed
Nf2
KO3/+
mice developed tumoural ascites and mesothelioma at a higher frequency than their wild-type (WT) counterparts (
P
<0.05). Six out of seven mesothelioma cell lines established from neoplastic ascitic fluids of
Nf2
KO3/+
mice exhibited loss of the WT
Nf2
allele and no neurofibromatosis type 2 protein expression was found in these cells. The results show the importance of the
NF2
gene in mesothelial oncogenesis, the potential association of asbestos exposure and tumour suppressor gene inactivation, and suggest that
NF2
gene mutation may be a susceptibility factor to asbestos.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Asbestos</subject><subject>Asbestos, Crocidolite - toxicity</subject><subject>Ascites</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biodiversity and Ecology</subject><subject>Biological and medical sciences</subject><subject>Cell Biology</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell growth</subject><subject>Cell physiology</subject><subject>Crocidolite</subject><subject>Ecology, environment</subject><subject>Ecosystems</subject><subject>Ecotoxicology</subject><subject>Environmental Sciences</subject><subject>Fibers</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric cancer</subject><subject>Genes, Neurofibromatosis 2</subject><subject>Genetic Predisposition to Disease</subject><subject>Genomics</subject><subject>Global Changes</subject><subject>Health</subject><subject>Hemizygosity</subject><subject>Human Genetics</subject><subject>Inoculation</subject><subject>Internal Medicine</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesothelioma</subject><subject>Mesothelioma - genetics</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Molecular and cellular biology</subject><subject>Molecular biology</subject><subject>Mutation</subject><subject>Neurofibromatosis</subject><subject>Neurofibromatosis 2</subject><subject>Neurofibromin 2</subject><subject>oncogenomics</subject><subject>Oncology</subject><subject>Peritoneal Neoplasms - genetics</subject><subject>Peritoneal Neoplasms - pathology</subject><subject>Point mutation</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Signal transduction</subject><subject>Susceptibility</subject><subject>Toxicology</subject><subject>Tumor suppressor genes</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1ks-LEzEUxwdR3Lp69SiDouBhukkmySTHsqgVil70HJJMppsyndS8mZX61_uGFguySw4hL5_345t8i-I1JUtKanUDu2Ua_JIyIoWunxQLyhtZCaH502JBtCCVZjW7Kl4A7AghjSbseXFFmSKMqWZRdOuwj3-O2wRxPJapK791rIxQWoDkox1DW_6O410ZB5-DBTzCBD4cxuhiP6eMCVkXYExQxaGdPCKHkOOYhmD7cpz2acrwsnjW2R7Cq_N-Xfz8_OnH7brafP_y9Xa1qbzgaqwEbxvClKdC1t4Gy4TTUlpXS0UbLrVsnOOacCV9LaRsPGWsFa1zrnGya3R9XXw81b2zvTnkuLf5aJKNZr3amDlGqGaKE3FPkf1wYg85_ZpQgdlHlNb3dghpAkOVIjUnBMF3_4E71DSgDsMkpzXTmnOk3j5KsQYLUSoupba2DyYOXRqz9XNfs6JKM6pwPqSWD1C4Wvwsjw_bRYw_lOBzAsih-6edEjP7xMDOoE_M2SeY8OY87OT2ob3gZ2Mg8P4MWPC277IdfIQLx5WgRM5vc3PiAK-GbcgX1Y-0_guWjNM9</recordid><startdate>20030612</startdate><enddate>20030612</enddate><creator>Fleury-Feith, Jocelyne</creator><creator>Lecomte, Céline</creator><creator>Renier, Annie</creator><creator>Matrat, Mireille</creator><creator>Kheuang, Laurence</creator><creator>Abramowski, Vincent</creator><creator>Levy, Françoise</creator><creator>Janin, Anne</creator><creator>Giovannini, Marco</creator><creator>Jaurand, Marie-Claude</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><general>Nature Publishing Group [1987-....]</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2461-7473</orcidid></search><sort><creationdate>20030612</creationdate><title>Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours</title><author>Fleury-Feith, Jocelyne ; Lecomte, Céline ; Renier, Annie ; Matrat, Mireille ; Kheuang, Laurence ; Abramowski, Vincent ; Levy, Françoise ; Janin, Anne ; Giovannini, Marco ; Jaurand, Marie-Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-54d7028c1563caea25b966ab3681746967bb490486c35667c122d5dbbb7b6f793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Asbestos</topic><topic>Asbestos, Crocidolite - toxicity</topic><topic>Ascites</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biodiversity and Ecology</topic><topic>Biological and medical sciences</topic><topic>Cell Biology</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell growth</topic><topic>Cell physiology</topic><topic>Crocidolite</topic><topic>Ecology, environment</topic><topic>Ecosystems</topic><topic>Ecotoxicology</topic><topic>Environmental Sciences</topic><topic>Fibers</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric cancer</topic><topic>Genes, Neurofibromatosis 2</topic><topic>Genetic Predisposition to Disease</topic><topic>Genomics</topic><topic>Global Changes</topic><topic>Health</topic><topic>Hemizygosity</topic><topic>Human Genetics</topic><topic>Inoculation</topic><topic>Internal Medicine</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mesothelioma</topic><topic>Mesothelioma - genetics</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Molecular and cellular biology</topic><topic>Molecular biology</topic><topic>Mutation</topic><topic>Neurofibromatosis</topic><topic>Neurofibromatosis 2</topic><topic>Neurofibromin 2</topic><topic>oncogenomics</topic><topic>Oncology</topic><topic>Peritoneal Neoplasms - genetics</topic><topic>Peritoneal Neoplasms - pathology</topic><topic>Point mutation</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Signal transduction</topic><topic>Susceptibility</topic><topic>Toxicology</topic><topic>Tumor suppressor genes</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fleury-Feith, Jocelyne</creatorcontrib><creatorcontrib>Lecomte, Céline</creatorcontrib><creatorcontrib>Renier, Annie</creatorcontrib><creatorcontrib>Matrat, Mireille</creatorcontrib><creatorcontrib>Kheuang, Laurence</creatorcontrib><creatorcontrib>Abramowski, Vincent</creatorcontrib><creatorcontrib>Levy, Françoise</creatorcontrib><creatorcontrib>Janin, Anne</creatorcontrib><creatorcontrib>Giovannini, Marco</creatorcontrib><creatorcontrib>Jaurand, Marie-Claude</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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Annie</au><au>Matrat, Mireille</au><au>Kheuang, Laurence</au><au>Abramowski, Vincent</au><au>Levy, Françoise</au><au>Janin, Anne</au><au>Giovannini, Marco</au><au>Jaurand, Marie-Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2003-06-12</date><risdate>2003</risdate><volume>22</volume><issue>24</issue><spage>3799</spage><epage>3805</epage><pages>3799-3805</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>Biallelic
NF2
gene inactivation is frequently found in human malignant mesothelioma. In order to assess whether
NF2
hemizygosity may enhance susceptibility to asbestos fibres, we investigated the
Nf2
status in mesothelioma developed in mice presenting a heterozygous mutation of the
Nf2
gene (
Nf2
KO3/+
), after intraperitoneal inoculation of crocidolite fibres. Asbestos-exposed
Nf2
KO3/+
mice developed tumoural ascites and mesothelioma at a higher frequency than their wild-type (WT) counterparts (
P
<0.05). Six out of seven mesothelioma cell lines established from neoplastic ascitic fluids of
Nf2
KO3/+
mice exhibited loss of the WT
Nf2
allele and no neurofibromatosis type 2 protein expression was found in these cells. The results show the importance of the
NF2
gene in mesothelial oncogenesis, the potential association of asbestos exposure and tumour suppressor gene inactivation, and suggest that
NF2
gene mutation may be a susceptibility factor to asbestos.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>12802287</pmid><doi>10.1038/sj.onc.1206593</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2461-7473</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-9232 |
| ispartof | Oncogene, 2003-06, Vol.22 (24), p.3799-3805 |
| issn | 0950-9232 1476-5594 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01928405v1 |
| source | MEDLINE; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Animals Apoptosis Asbestos Asbestos, Crocidolite - toxicity Ascites Biochemistry, Molecular Biology Biodiversity and Ecology Biological and medical sciences Cell Biology Cell differentiation, maturation, development, hematopoiesis Cell growth Cell physiology Crocidolite Ecology, environment Ecosystems Ecotoxicology Environmental Sciences Fibers Fundamental and applied biological sciences. Psychology Gastric cancer Genes, Neurofibromatosis 2 Genetic Predisposition to Disease Genomics Global Changes Health Hemizygosity Human Genetics Inoculation Internal Medicine Life Sciences Medicine Medicine & Public Health Mesothelioma Mesothelioma - genetics Mice Mice, Nude Molecular and cellular biology Molecular biology Mutation Neurofibromatosis Neurofibromatosis 2 Neurofibromin 2 oncogenomics Oncology Peritoneal Neoplasms - genetics Peritoneal Neoplasms - pathology Point mutation Reverse Transcriptase Polymerase Chain Reaction Signal transduction Susceptibility Toxicology Tumor suppressor genes Tumorigenesis Tumors |
| title | Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours |
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