Diagnostic value of 3DFLAIR in clinical practice for the detection of infratentorial lesions in multiple sclerosis in regard to dual echo T2 sequences
•3DFLAIR was proved to be more sensitive in detecting infratentorial lesions than 2DT2/PD.•The more the radiologist is specialized and experienced, the more his sensibility to detect lesions is optimized.•Lesion detection accuracy is important in MS follow-up that takes into account new lesions numb...
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| Veröffentlicht in: | European journal of radiology 2018-05, Vol.102, p.146-151 |
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| creator | Hannoun, Salem Heidelberg, Damien Hourani, Roula Nguyen, Thi Thuy Trang Brisset, Jean-Christophe Grand, Sylvie Kremer, Stéphane Bonneville, Fabrice Guttmann, Charles R.G. Dousset, Vincent Cotton, François |
| description | •3DFLAIR was proved to be more sensitive in detecting infratentorial lesions than 2DT2/PD.•The more the radiologist is specialized and experienced, the more his sensibility to detect lesions is optimized.•Lesion detection accuracy is important in MS follow-up that takes into account new lesions number to adapt patients’ treatment.
The aim of this prospective study is to investigate and evaluate in clinical practice the diagnostic impact of 3DFLAIR in regards to 2DT2/PD in terms of infratentorial lesions detection in multiple sclerosis (MS).
164 MS patients from the OFSEP database were reviewed retrospectively. MR examinations were performed on 1.5T or 3T systems from four different centers. Infratentorial lesions were counted and allocated to different regions of the posterior fossa by three raters independently (junior resident, resident with an expertise in neuroradiology, and senior neuro-radiologist) on the 3DFLAIR and 2DT2/PD. Both sequences do not have the same spatial resolution but reflect what is recommended by most of the consensus and done in clinical practice.
With an overall number of 528 for Rater-1 and 798 for Rater-2 infratentorial lesions, 3DFLAIR had a significantly higher number of lesions detected than 2DT2/PD (303 for Rater-1 and 370 for Rater-2). The prevalence of trigeminal lesions detected by using 3DFLAIR was also significantly higher than 2DT2/PD. ROC analysis showed 3DFLAIR to be more specific and sensitive than 2DT2/PD. An overall difference between all three Raters has been observed. The more the Rater is experienced the more lesions he detects.
Along with the radiologist ability to detect lesions based on his level of experience, the OFSEP optimized 3DFLAIR can significantly improve infratentorial lesion detection in MS compared to 2DT2/PD. This is important in MS follow-up that takes into account new lesions number to adapt patients’ treatment. |
| doi_str_mv | 10.1016/j.ejrad.2018.03.017 |
| format | Article |
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The aim of this prospective study is to investigate and evaluate in clinical practice the diagnostic impact of 3DFLAIR in regards to 2DT2/PD in terms of infratentorial lesions detection in multiple sclerosis (MS).
164 MS patients from the OFSEP database were reviewed retrospectively. MR examinations were performed on 1.5T or 3T systems from four different centers. Infratentorial lesions were counted and allocated to different regions of the posterior fossa by three raters independently (junior resident, resident with an expertise in neuroradiology, and senior neuro-radiologist) on the 3DFLAIR and 2DT2/PD. Both sequences do not have the same spatial resolution but reflect what is recommended by most of the consensus and done in clinical practice.
With an overall number of 528 for Rater-1 and 798 for Rater-2 infratentorial lesions, 3DFLAIR had a significantly higher number of lesions detected than 2DT2/PD (303 for Rater-1 and 370 for Rater-2). The prevalence of trigeminal lesions detected by using 3DFLAIR was also significantly higher than 2DT2/PD. ROC analysis showed 3DFLAIR to be more specific and sensitive than 2DT2/PD. An overall difference between all three Raters has been observed. The more the Rater is experienced the more lesions he detects.
Along with the radiologist ability to detect lesions based on his level of experience, the OFSEP optimized 3DFLAIR can significantly improve infratentorial lesion detection in MS compared to 2DT2/PD. This is important in MS follow-up that takes into account new lesions number to adapt patients’ treatment.</description><identifier>ISSN: 0720-048X</identifier><identifier>EISSN: 1872-7727</identifier><identifier>DOI: 10.1016/j.ejrad.2018.03.017</identifier><identifier>PMID: 29685528</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>2DT2/PD ; 3DFLAIR ; Adult ; Bioengineering ; Brain Diseases - diagnosis ; Clinical Competence - standards ; Epidemiologic Methods ; Female ; Humans ; Imaging ; Imaging, Three-Dimensional ; Infratentorial region ; Lesion detection ; Life Sciences ; Magnetic Resonance Imaging - methods ; Male ; Multiple sclerosis ; Multiple Sclerosis - diagnosis ; Observer Variation ; Radiologists - standards</subject><ispartof>European journal of radiology, 2018-05, Vol.102, p.146-151</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-116de794e2b383ec5233c6fc9ea181fb74716eb2d559be0b80df018356d3c8053</citedby><cites>FETCH-LOGICAL-c393t-116de794e2b383ec5233c6fc9ea181fb74716eb2d559be0b80df018356d3c8053</cites><orcidid>0000-0002-5982-3242 ; 0000-0002-7947-3622 ; 0000-0003-0701-3667 ; 0000-0003-2950-8759 ; 0000-0003-0046-2478 ; 0000-0002-1977-5987 ; 0000-0001-8588-5087</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejrad.2018.03.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29685528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01919566$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Hannoun, Salem</creatorcontrib><creatorcontrib>Heidelberg, Damien</creatorcontrib><creatorcontrib>Hourani, Roula</creatorcontrib><creatorcontrib>Nguyen, Thi Thuy Trang</creatorcontrib><creatorcontrib>Brisset, Jean-Christophe</creatorcontrib><creatorcontrib>Grand, Sylvie</creatorcontrib><creatorcontrib>Kremer, Stéphane</creatorcontrib><creatorcontrib>Bonneville, Fabrice</creatorcontrib><creatorcontrib>Guttmann, Charles R.G.</creatorcontrib><creatorcontrib>Dousset, Vincent</creatorcontrib><creatorcontrib>Cotton, François</creatorcontrib><creatorcontrib>for the Imaging Working Group of the Observatoire Français de la Sclérose en Plaques</creatorcontrib><creatorcontrib>Imaging Working Group of the Observatoire Français de la Sclérose en Plaques</creatorcontrib><title>Diagnostic value of 3DFLAIR in clinical practice for the detection of infratentorial lesions in multiple sclerosis in regard to dual echo T2 sequences</title><title>European journal of radiology</title><addtitle>Eur J Radiol</addtitle><description>•3DFLAIR was proved to be more sensitive in detecting infratentorial lesions than 2DT2/PD.•The more the radiologist is specialized and experienced, the more his sensibility to detect lesions is optimized.•Lesion detection accuracy is important in MS follow-up that takes into account new lesions number to adapt patients’ treatment.
The aim of this prospective study is to investigate and evaluate in clinical practice the diagnostic impact of 3DFLAIR in regards to 2DT2/PD in terms of infratentorial lesions detection in multiple sclerosis (MS).
164 MS patients from the OFSEP database were reviewed retrospectively. MR examinations were performed on 1.5T or 3T systems from four different centers. Infratentorial lesions were counted and allocated to different regions of the posterior fossa by three raters independently (junior resident, resident with an expertise in neuroradiology, and senior neuro-radiologist) on the 3DFLAIR and 2DT2/PD. Both sequences do not have the same spatial resolution but reflect what is recommended by most of the consensus and done in clinical practice.
With an overall number of 528 for Rater-1 and 798 for Rater-2 infratentorial lesions, 3DFLAIR had a significantly higher number of lesions detected than 2DT2/PD (303 for Rater-1 and 370 for Rater-2). The prevalence of trigeminal lesions detected by using 3DFLAIR was also significantly higher than 2DT2/PD. ROC analysis showed 3DFLAIR to be more specific and sensitive than 2DT2/PD. An overall difference between all three Raters has been observed. The more the Rater is experienced the more lesions he detects.
Along with the radiologist ability to detect lesions based on his level of experience, the OFSEP optimized 3DFLAIR can significantly improve infratentorial lesion detection in MS compared to 2DT2/PD. This is important in MS follow-up that takes into account new lesions number to adapt patients’ treatment.</description><subject>2DT2/PD</subject><subject>3DFLAIR</subject><subject>Adult</subject><subject>Bioengineering</subject><subject>Brain Diseases - diagnosis</subject><subject>Clinical Competence - standards</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Imaging, Three-Dimensional</subject><subject>Infratentorial region</subject><subject>Lesion detection</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Observer Variation</subject><subject>Radiologists - standards</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEUhS0EomnhCZCQl7CYcG3H45kFi6ilP1IkJFQkdpbHvtM4csbBnonUF-F58TSlS1aWrr9zrn0OIR8YLBmw-stuibtk3JIDa5YglsDUK7JgjeKVUly9JgtQHCpYNb_OyHnOOwCQq5a_JWe8rRspebMgf668eRhiHr2lRxMmpLGn4up6s777Qf1AbfCDtybQQzK2QEj7mOi4RepwxDKJw6zwQ5_MiMMYky9wwFwu8mywn8LoDwFptgFTzP5pmvDBJEfHSN1UeLTbSO85zfh7wsFifkfe9CZkfP98XpCf19_uL2-rzfebu8v1prKiFWPFWO1QtSvknWgEWsmFsHVvWzSsYX2nVorV2HEnZdshdA24vqQlZO2EbUCKC_L55Ls1QR-S35v0qKPx-na90fMMWMtaWddHVthPJ_aQYnlmHvXeZ4shmAHjlDUHwYBL4Kqg4oTa8uOcsH_xZqDn8vROP5Wn5_I0iLJnVn18XjB1e3Qvmn9tFeDrCcASydFj0tn6OS_nU-lCu-j_u-AvrOusjw</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Hannoun, Salem</creator><creator>Heidelberg, Damien</creator><creator>Hourani, Roula</creator><creator>Nguyen, Thi Thuy Trang</creator><creator>Brisset, Jean-Christophe</creator><creator>Grand, Sylvie</creator><creator>Kremer, Stéphane</creator><creator>Bonneville, Fabrice</creator><creator>Guttmann, Charles R.G.</creator><creator>Dousset, Vincent</creator><creator>Cotton, François</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5982-3242</orcidid><orcidid>https://orcid.org/0000-0002-7947-3622</orcidid><orcidid>https://orcid.org/0000-0003-0701-3667</orcidid><orcidid>https://orcid.org/0000-0003-2950-8759</orcidid><orcidid>https://orcid.org/0000-0003-0046-2478</orcidid><orcidid>https://orcid.org/0000-0002-1977-5987</orcidid><orcidid>https://orcid.org/0000-0001-8588-5087</orcidid></search><sort><creationdate>201805</creationdate><title>Diagnostic value of 3DFLAIR in clinical practice for the detection of infratentorial lesions in multiple sclerosis in regard to dual echo T2 sequences</title><author>Hannoun, Salem ; 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The aim of this prospective study is to investigate and evaluate in clinical practice the diagnostic impact of 3DFLAIR in regards to 2DT2/PD in terms of infratentorial lesions detection in multiple sclerosis (MS).
164 MS patients from the OFSEP database were reviewed retrospectively. MR examinations were performed on 1.5T or 3T systems from four different centers. Infratentorial lesions were counted and allocated to different regions of the posterior fossa by three raters independently (junior resident, resident with an expertise in neuroradiology, and senior neuro-radiologist) on the 3DFLAIR and 2DT2/PD. Both sequences do not have the same spatial resolution but reflect what is recommended by most of the consensus and done in clinical practice.
With an overall number of 528 for Rater-1 and 798 for Rater-2 infratentorial lesions, 3DFLAIR had a significantly higher number of lesions detected than 2DT2/PD (303 for Rater-1 and 370 for Rater-2). The prevalence of trigeminal lesions detected by using 3DFLAIR was also significantly higher than 2DT2/PD. ROC analysis showed 3DFLAIR to be more specific and sensitive than 2DT2/PD. An overall difference between all three Raters has been observed. The more the Rater is experienced the more lesions he detects.
Along with the radiologist ability to detect lesions based on his level of experience, the OFSEP optimized 3DFLAIR can significantly improve infratentorial lesion detection in MS compared to 2DT2/PD. This is important in MS follow-up that takes into account new lesions number to adapt patients’ treatment.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29685528</pmid><doi>10.1016/j.ejrad.2018.03.017</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5982-3242</orcidid><orcidid>https://orcid.org/0000-0002-7947-3622</orcidid><orcidid>https://orcid.org/0000-0003-0701-3667</orcidid><orcidid>https://orcid.org/0000-0003-2950-8759</orcidid><orcidid>https://orcid.org/0000-0003-0046-2478</orcidid><orcidid>https://orcid.org/0000-0002-1977-5987</orcidid><orcidid>https://orcid.org/0000-0001-8588-5087</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of radiology, 2018-05, Vol.102, p.146-151 |
| issn | 0720-048X 1872-7727 |
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| subjects | 2DT2/PD 3DFLAIR Adult Bioengineering Brain Diseases - diagnosis Clinical Competence - standards Epidemiologic Methods Female Humans Imaging Imaging, Three-Dimensional Infratentorial region Lesion detection Life Sciences Magnetic Resonance Imaging - methods Male Multiple sclerosis Multiple Sclerosis - diagnosis Observer Variation Radiologists - standards |
| title | Diagnostic value of 3DFLAIR in clinical practice for the detection of infratentorial lesions in multiple sclerosis in regard to dual echo T2 sequences |
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