Suspicious liver nodule in chronic liver disease: Usefulness of a second biopsy
To assess the usefulness of a second biopsy when the first one was inconclusive in patients with a liver nodule found during the follow-up for chronic liver disease. Among 381 patients (544 nodules) included in a prospective study designed to evaluate the accuracy of imaging for the diagnosis of sma...
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| Veröffentlicht in: | Diagnostic and interventional imaging 2018-07, Vol.99 (7-8), p.493-499 |
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| creator | Cartier, V. Crouan, A. Esvan, M. Oberti, F. Michalak, S. Gallix, B. Seror, O. Paisant, A. Vilgrain, V. Aubé, C. Anty, R. Archambeaud, I. Baudin, G. Brun, V. Chevallier, P. Cuilleron, M. Dumortie, J. Duvoux, C. Estivalet, L. Frampas, E. Gandon, Y. Guillygomarc’h, A. Guiu, B. Lebigot, J. Le Pennec, V. Luciani, A. Minello, A. Ollivier-Hourmand, I. Pilleul, F. Patouillard, B. Sylvain, C. Tasu, J.P. |
| description | To assess the usefulness of a second biopsy when the first one was inconclusive in patients with a liver nodule found during the follow-up for chronic liver disease.
Among 381 patients (544 nodules) included in a prospective study designed to evaluate the accuracy of imaging for the diagnosis of small hepatocellular carcinoma (HCC) in chronic liver disease, 254 nodules were biopsied. The following histological results were considered as conclusive: HCC, dysplastic or regenerative nodule, and other identified tumors (benign or malignant). For nodules with inconclusive results (e.g. fibrosis or no definite focal lesion), a second biopsy was suggested, but was not mandatory.
A total of 242 patients (194 men, 48 women; mean age, 61.9±9.5 [SD]; range: 40.2–89.0years) with 254 nodules underwent a first biopsy. Mean nodule diameter was 19.2±5.4mm (range: 10–33mm). The first biopsy was conclusive in 189/254 nodules (74.4%): 157 HCCs (83.1%), 11 regenerative nodules (5.8%), 10 dysplastic nodules (5.3%), 3 cholangiocarcinomas (1.6%), and 8 other tumors (4.2%). Among the 65 nodules for which the first biopsy was inconclusive, a second biopsy was performed for 17 nodules in 16 patients within 6 months of the first one. It was conclusive in 13/17 nodules (76.5%): 10 HCCs (76.9%), 2 dysplastic nodules (15.4%), and 1 other tumor (7.7%). In 4/17 nodules (23.5%), no definitive diagnosis could be provided.
The diagnostic yield of a second biopsy of a suspicious lesion suggestive of HCC in chronic liver disease is not decreased compared to the first one. Repeated biopsy after a first negative one could be an alternative option to the follow-up of patients with chronic liver disease. |
| doi_str_mv | 10.1016/j.diii.2017.12.014 |
| format | Article |
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Among 381 patients (544 nodules) included in a prospective study designed to evaluate the accuracy of imaging for the diagnosis of small hepatocellular carcinoma (HCC) in chronic liver disease, 254 nodules were biopsied. The following histological results were considered as conclusive: HCC, dysplastic or regenerative nodule, and other identified tumors (benign or malignant). For nodules with inconclusive results (e.g. fibrosis or no definite focal lesion), a second biopsy was suggested, but was not mandatory.
A total of 242 patients (194 men, 48 women; mean age, 61.9±9.5 [SD]; range: 40.2–89.0years) with 254 nodules underwent a first biopsy. Mean nodule diameter was 19.2±5.4mm (range: 10–33mm). The first biopsy was conclusive in 189/254 nodules (74.4%): 157 HCCs (83.1%), 11 regenerative nodules (5.8%), 10 dysplastic nodules (5.3%), 3 cholangiocarcinomas (1.6%), and 8 other tumors (4.2%). Among the 65 nodules for which the first biopsy was inconclusive, a second biopsy was performed for 17 nodules in 16 patients within 6 months of the first one. It was conclusive in 13/17 nodules (76.5%): 10 HCCs (76.9%), 2 dysplastic nodules (15.4%), and 1 other tumor (7.7%). In 4/17 nodules (23.5%), no definitive diagnosis could be provided.
The diagnostic yield of a second biopsy of a suspicious lesion suggestive of HCC in chronic liver disease is not decreased compared to the first one. Repeated biopsy after a first negative one could be an alternative option to the follow-up of patients with chronic liver disease.</description><identifier>ISSN: 2211-5684</identifier><identifier>EISSN: 2211-5684</identifier><identifier>DOI: 10.1016/j.diii.2017.12.014</identifier><identifier>PMID: 29501461</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bioengineering ; Biopsy ; Carcinoma, Hepatocellular - complications ; Carcinoma, Hepatocellular - pathology ; Chronic Disease ; Diagnostic yield ; Efficacy study ; Female ; Hepatocellular carcinoma (HCC) ; Humans ; Imaging ; Imaging guidance ; Life Sciences ; Liver Diseases - complications ; Liver Diseases - pathology ; Liver Neoplasms - complications ; Liver Neoplasms - pathology ; Male ; Middle Aged ; Percutaneous liver biopsy ; Prospective Studies</subject><ispartof>Diagnostic and interventional imaging, 2018-07, Vol.99 (7-8), p.493-499</ispartof><rights>2018 Soci showét showé françaises de radiologie</rights><rights>Copyright © 2018 Soci showét showé françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-7398746a7876ead6a842ca815d4b787dea9a6cdeb51babcc254475baf56f911d3</citedby><cites>FETCH-LOGICAL-c434t-7398746a7876ead6a842ca815d4b787dea9a6cdeb51babcc254475baf56f911d3</cites><orcidid>0000-0001-6680-8991 ; 0000-0002-9643-5230 ; 0000-0003-0331-9474</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29501461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01918685$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Cartier, V.</creatorcontrib><creatorcontrib>Crouan, A.</creatorcontrib><creatorcontrib>Esvan, M.</creatorcontrib><creatorcontrib>Oberti, F.</creatorcontrib><creatorcontrib>Michalak, S.</creatorcontrib><creatorcontrib>Gallix, B.</creatorcontrib><creatorcontrib>Seror, O.</creatorcontrib><creatorcontrib>Paisant, A.</creatorcontrib><creatorcontrib>Vilgrain, V.</creatorcontrib><creatorcontrib>Aubé, C.</creatorcontrib><creatorcontrib>Anty, R.</creatorcontrib><creatorcontrib>Archambeaud, I.</creatorcontrib><creatorcontrib>Baudin, G.</creatorcontrib><creatorcontrib>Brun, V.</creatorcontrib><creatorcontrib>Chevallier, P.</creatorcontrib><creatorcontrib>Cuilleron, M.</creatorcontrib><creatorcontrib>Dumortie, J.</creatorcontrib><creatorcontrib>Duvoux, C.</creatorcontrib><creatorcontrib>Estivalet, L.</creatorcontrib><creatorcontrib>Frampas, E.</creatorcontrib><creatorcontrib>Gandon, Y.</creatorcontrib><creatorcontrib>Guillygomarc’h, A.</creatorcontrib><creatorcontrib>Guiu, B.</creatorcontrib><creatorcontrib>Lebigot, J.</creatorcontrib><creatorcontrib>Le Pennec, V.</creatorcontrib><creatorcontrib>Luciani, A.</creatorcontrib><creatorcontrib>Minello, A.</creatorcontrib><creatorcontrib>Ollivier-Hourmand, I.</creatorcontrib><creatorcontrib>Pilleul, F.</creatorcontrib><creatorcontrib>Patouillard, B.</creatorcontrib><creatorcontrib>Sylvain, C.</creatorcontrib><creatorcontrib>Tasu, J.P.</creatorcontrib><creatorcontrib>CHIC group</creatorcontrib><title>Suspicious liver nodule in chronic liver disease: Usefulness of a second biopsy</title><title>Diagnostic and interventional imaging</title><addtitle>Diagn Interv Imaging</addtitle><description>To assess the usefulness of a second biopsy when the first one was inconclusive in patients with a liver nodule found during the follow-up for chronic liver disease.
Among 381 patients (544 nodules) included in a prospective study designed to evaluate the accuracy of imaging for the diagnosis of small hepatocellular carcinoma (HCC) in chronic liver disease, 254 nodules were biopsied. The following histological results were considered as conclusive: HCC, dysplastic or regenerative nodule, and other identified tumors (benign or malignant). For nodules with inconclusive results (e.g. fibrosis or no definite focal lesion), a second biopsy was suggested, but was not mandatory.
A total of 242 patients (194 men, 48 women; mean age, 61.9±9.5 [SD]; range: 40.2–89.0years) with 254 nodules underwent a first biopsy. Mean nodule diameter was 19.2±5.4mm (range: 10–33mm). The first biopsy was conclusive in 189/254 nodules (74.4%): 157 HCCs (83.1%), 11 regenerative nodules (5.8%), 10 dysplastic nodules (5.3%), 3 cholangiocarcinomas (1.6%), and 8 other tumors (4.2%). Among the 65 nodules for which the first biopsy was inconclusive, a second biopsy was performed for 17 nodules in 16 patients within 6 months of the first one. It was conclusive in 13/17 nodules (76.5%): 10 HCCs (76.9%), 2 dysplastic nodules (15.4%), and 1 other tumor (7.7%). In 4/17 nodules (23.5%), no definitive diagnosis could be provided.
The diagnostic yield of a second biopsy of a suspicious lesion suggestive of HCC in chronic liver disease is not decreased compared to the first one. Repeated biopsy after a first negative one could be an alternative option to the follow-up of patients with chronic liver disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bioengineering</subject><subject>Biopsy</subject><subject>Carcinoma, Hepatocellular - complications</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Chronic Disease</subject><subject>Diagnostic yield</subject><subject>Efficacy study</subject><subject>Female</subject><subject>Hepatocellular carcinoma (HCC)</subject><subject>Humans</subject><subject>Imaging</subject><subject>Imaging guidance</subject><subject>Life Sciences</subject><subject>Liver Diseases - complications</subject><subject>Liver Diseases - pathology</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Percutaneous liver biopsy</subject><subject>Prospective Studies</subject><issn>2211-5684</issn><issn>2211-5684</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFrGzEQhUVoSEKaP9BD0bE9eKuRtdrd0ksIbVMw5JDmLLTSLBmzXrkaryH_PjJ2Q0-di4bH996gJ8QHUBUosF_WVSSiSitoKtCVAnMmrrQGWNS2Ne_-2S_FDfNalbHFaMyFuNRdXQwWrsTD48xbCpRmliPtMcspxXlESZMMzzlNFE56JEbP-FU-MQ7zOCGzTIP0kjGkKcqe0pZf3ovzwY-MN6f3Wjz9-P777n6xevj56-52tQhmaXaLZtm1jbG-aRuLPlrfGh18C3U0fdEi-s7bELGvofd9CLo2pql7P9R26ADi8lp8PuY--9FtM218fnHJk7u_XbmDpqCD1rb1Hgr76chuc_ozI-_chjjgOPoJy79d6VC1RnXLpqD6iIacmDMOb9mg3KF3t3aH3g-exoEuZ0wxfTzlz_0G45vlb8sF-HYEsDSyJ8yOA-EUMFLGsHMx0f_yXwFiNpL4</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Cartier, V.</creator><creator>Crouan, A.</creator><creator>Esvan, M.</creator><creator>Oberti, F.</creator><creator>Michalak, S.</creator><creator>Gallix, B.</creator><creator>Seror, O.</creator><creator>Paisant, A.</creator><creator>Vilgrain, V.</creator><creator>Aubé, C.</creator><creator>Anty, R.</creator><creator>Archambeaud, I.</creator><creator>Baudin, G.</creator><creator>Brun, V.</creator><creator>Chevallier, P.</creator><creator>Cuilleron, M.</creator><creator>Dumortie, J.</creator><creator>Duvoux, C.</creator><creator>Estivalet, L.</creator><creator>Frampas, E.</creator><creator>Gandon, Y.</creator><creator>Guillygomarc’h, A.</creator><creator>Guiu, B.</creator><creator>Lebigot, J.</creator><creator>Le Pennec, V.</creator><creator>Luciani, A.</creator><creator>Minello, A.</creator><creator>Ollivier-Hourmand, I.</creator><creator>Pilleul, F.</creator><creator>Patouillard, B.</creator><creator>Sylvain, C.</creator><creator>Tasu, J.P.</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-6680-8991</orcidid><orcidid>https://orcid.org/0000-0002-9643-5230</orcidid><orcidid>https://orcid.org/0000-0003-0331-9474</orcidid></search><sort><creationdate>20180701</creationdate><title>Suspicious liver nodule in chronic liver disease: Usefulness of a second biopsy</title><author>Cartier, V. ; Crouan, A. ; Esvan, M. ; Oberti, F. ; Michalak, S. ; Gallix, B. ; Seror, O. ; Paisant, A. ; Vilgrain, V. ; Aubé, C. ; Anty, R. ; Archambeaud, I. ; Baudin, G. ; Brun, V. ; Chevallier, P. ; Cuilleron, M. ; Dumortie, J. ; Duvoux, C. ; Estivalet, L. ; Frampas, E. ; Gandon, Y. ; Guillygomarc’h, A. ; Guiu, B. ; Lebigot, J. ; Le Pennec, V. ; Luciani, A. ; Minello, A. ; Ollivier-Hourmand, I. ; Pilleul, F. ; Patouillard, B. ; Sylvain, C. ; Tasu, J.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-7398746a7876ead6a842ca815d4b787dea9a6cdeb51babcc254475baf56f911d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bioengineering</topic><topic>Biopsy</topic><topic>Carcinoma, Hepatocellular - complications</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Chronic Disease</topic><topic>Diagnostic yield</topic><topic>Efficacy study</topic><topic>Female</topic><topic>Hepatocellular carcinoma (HCC)</topic><topic>Humans</topic><topic>Imaging</topic><topic>Imaging guidance</topic><topic>Life Sciences</topic><topic>Liver Diseases - complications</topic><topic>Liver Diseases - pathology</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Percutaneous liver biopsy</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cartier, V.</creatorcontrib><creatorcontrib>Crouan, A.</creatorcontrib><creatorcontrib>Esvan, M.</creatorcontrib><creatorcontrib>Oberti, F.</creatorcontrib><creatorcontrib>Michalak, S.</creatorcontrib><creatorcontrib>Gallix, B.</creatorcontrib><creatorcontrib>Seror, O.</creatorcontrib><creatorcontrib>Paisant, A.</creatorcontrib><creatorcontrib>Vilgrain, V.</creatorcontrib><creatorcontrib>Aubé, C.</creatorcontrib><creatorcontrib>Anty, R.</creatorcontrib><creatorcontrib>Archambeaud, I.</creatorcontrib><creatorcontrib>Baudin, G.</creatorcontrib><creatorcontrib>Brun, V.</creatorcontrib><creatorcontrib>Chevallier, P.</creatorcontrib><creatorcontrib>Cuilleron, M.</creatorcontrib><creatorcontrib>Dumortie, J.</creatorcontrib><creatorcontrib>Duvoux, C.</creatorcontrib><creatorcontrib>Estivalet, L.</creatorcontrib><creatorcontrib>Frampas, E.</creatorcontrib><creatorcontrib>Gandon, Y.</creatorcontrib><creatorcontrib>Guillygomarc’h, A.</creatorcontrib><creatorcontrib>Guiu, B.</creatorcontrib><creatorcontrib>Lebigot, J.</creatorcontrib><creatorcontrib>Le Pennec, V.</creatorcontrib><creatorcontrib>Luciani, A.</creatorcontrib><creatorcontrib>Minello, A.</creatorcontrib><creatorcontrib>Ollivier-Hourmand, I.</creatorcontrib><creatorcontrib>Pilleul, F.</creatorcontrib><creatorcontrib>Patouillard, B.</creatorcontrib><creatorcontrib>Sylvain, C.</creatorcontrib><creatorcontrib>Tasu, J.P.</creatorcontrib><creatorcontrib>CHIC group</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Diagnostic and interventional imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cartier, V.</au><au>Crouan, A.</au><au>Esvan, M.</au><au>Oberti, F.</au><au>Michalak, S.</au><au>Gallix, B.</au><au>Seror, O.</au><au>Paisant, A.</au><au>Vilgrain, V.</au><au>Aubé, C.</au><au>Anty, R.</au><au>Archambeaud, I.</au><au>Baudin, G.</au><au>Brun, V.</au><au>Chevallier, P.</au><au>Cuilleron, M.</au><au>Dumortie, J.</au><au>Duvoux, C.</au><au>Estivalet, L.</au><au>Frampas, E.</au><au>Gandon, Y.</au><au>Guillygomarc’h, A.</au><au>Guiu, B.</au><au>Lebigot, J.</au><au>Le Pennec, V.</au><au>Luciani, A.</au><au>Minello, A.</au><au>Ollivier-Hourmand, I.</au><au>Pilleul, F.</au><au>Patouillard, B.</au><au>Sylvain, C.</au><au>Tasu, J.P.</au><aucorp>CHIC group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suspicious liver nodule in chronic liver disease: Usefulness of a second biopsy</atitle><jtitle>Diagnostic and interventional imaging</jtitle><addtitle>Diagn Interv Imaging</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>99</volume><issue>7-8</issue><spage>493</spage><epage>499</epage><pages>493-499</pages><issn>2211-5684</issn><eissn>2211-5684</eissn><abstract>To assess the usefulness of a second biopsy when the first one was inconclusive in patients with a liver nodule found during the follow-up for chronic liver disease.
Among 381 patients (544 nodules) included in a prospective study designed to evaluate the accuracy of imaging for the diagnosis of small hepatocellular carcinoma (HCC) in chronic liver disease, 254 nodules were biopsied. The following histological results were considered as conclusive: HCC, dysplastic or regenerative nodule, and other identified tumors (benign or malignant). For nodules with inconclusive results (e.g. fibrosis or no definite focal lesion), a second biopsy was suggested, but was not mandatory.
A total of 242 patients (194 men, 48 women; mean age, 61.9±9.5 [SD]; range: 40.2–89.0years) with 254 nodules underwent a first biopsy. Mean nodule diameter was 19.2±5.4mm (range: 10–33mm). The first biopsy was conclusive in 189/254 nodules (74.4%): 157 HCCs (83.1%), 11 regenerative nodules (5.8%), 10 dysplastic nodules (5.3%), 3 cholangiocarcinomas (1.6%), and 8 other tumors (4.2%). Among the 65 nodules for which the first biopsy was inconclusive, a second biopsy was performed for 17 nodules in 16 patients within 6 months of the first one. It was conclusive in 13/17 nodules (76.5%): 10 HCCs (76.9%), 2 dysplastic nodules (15.4%), and 1 other tumor (7.7%). In 4/17 nodules (23.5%), no definitive diagnosis could be provided.
The diagnostic yield of a second biopsy of a suspicious lesion suggestive of HCC in chronic liver disease is not decreased compared to the first one. Repeated biopsy after a first negative one could be an alternative option to the follow-up of patients with chronic liver disease.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>29501461</pmid><doi>10.1016/j.diii.2017.12.014</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6680-8991</orcidid><orcidid>https://orcid.org/0000-0002-9643-5230</orcidid><orcidid>https://orcid.org/0000-0003-0331-9474</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2211-5684 |
| ispartof | Diagnostic and interventional imaging, 2018-07, Vol.99 (7-8), p.493-499 |
| issn | 2211-5684 2211-5684 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01918685v1 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Bioengineering Biopsy Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - pathology Chronic Disease Diagnostic yield Efficacy study Female Hepatocellular carcinoma (HCC) Humans Imaging Imaging guidance Life Sciences Liver Diseases - complications Liver Diseases - pathology Liver Neoplasms - complications Liver Neoplasms - pathology Male Middle Aged Percutaneous liver biopsy Prospective Studies |
| title | Suspicious liver nodule in chronic liver disease: Usefulness of a second biopsy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T09%3A28%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Suspicious%20liver%20nodule%20in%20chronic%20liver%20disease:%20Usefulness%20of%20a%20second%20biopsy&rft.jtitle=Diagnostic%20and%20interventional%20imaging&rft.au=Cartier,%20V.&rft.aucorp=CHIC%20group&rft.date=2018-07-01&rft.volume=99&rft.issue=7-8&rft.spage=493&rft.epage=499&rft.pages=493-499&rft.issn=2211-5684&rft.eissn=2211-5684&rft_id=info:doi/10.1016/j.diii.2017.12.014&rft_dat=%3Cproquest_hal_p%3E2010840937%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2010840937&rft_id=info:pmid/29501461&rft_els_id=S2211568418300093&rfr_iscdi=true |