A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles

A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles

A versatile copper(i)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbones based on biorelevant indole/lactam scaffolds.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic & biomolecular chemistry 2017-04, Vol.15 (15), p.3304-3309
Hauptverfasser: Mardjan, M I D, Perie, S, Parrain, J-L, Commeiras, L
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Organic chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A versatile copper(i)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbones based on biorelevant indole/lactam scaffolds.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob00532f