Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders
Cerebral malaria, a reversible encephalopathy affecting young children, is a medical emergency requiring urgent clinical assessment and treatment. We performed a whole-transcriptomic analysis of blood samples from Malian children with cerebral or uncomplicated malaria. We focused on transcripts from...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 2017-09, Vol.216 (6), p.771-775 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 775 |
|---|---|
| container_issue | 6 |
| container_start_page | 771 |
| container_title | The Journal of infectious diseases |
| container_volume | 216 |
| creator | Cabantous, Sandrine Doumbo, Ogobara Poudiougou, Belco Louis, Laurence Barry, Abdoulaye Oumar, Aboubacar A. Traore, Abdoualye Marquet, Sandrine Dessein, Alain |
| description | Cerebral malaria, a reversible encephalopathy affecting young children, is a medical emergency requiring urgent clinical assessment and treatment. We performed a whole-transcriptomic analysis of blood samples from Malian children with cerebral or uncomplicated malaria. We focused on transcripts from pathways for which dysfunction has been associated with neurodegenerative disorders. We found that SNCA, SIAH2, UBB, HSPA1A, TUBB2A, and PINK1 were upregulated (fold-increases, ≥2.6), whereas UBD and PSMC5 were downregulated (fold-decreases, ≤4.39) in children with cerebral malaria, compared with those with uncomplicated malaria. These findings provide the first evidence for pathogenic mechanisms common to human cerebral malaria and neurodegenerative disorders. |
| doi_str_mv | 10.1093/infdis/jix359 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01902060v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>26491387</jstor_id><oup_id>10.1093/infdis/jix359</oup_id><sourcerecordid>26491387</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-9fcdc0a7f8687d394b5ee2815eb63edaffbb7981f706ef4878db157d7e2b01023</originalsourceid><addsrcrecordid>eNqFkUtP3DAURi1UVAbaJUuQl-0i4Efix3I0pVBpAKmCteXE161HSTy1kxH8ezIKj2VXV_ru0bnS_RA6peSCEs0vQ-9dyJeb8MQrfYAWtOKyEILyT2hBCGMFVVofoeOcN4SQkgv5GR0xpXlZMr1A9hp6wFdP2wQ5h9jjZW_b5xwy_g07sG3GeyDjVey6aTtEvIIEdbItvrWtTcFi2zt8B2OKDv5MbLJD2AH-EXJMDlL-gg795IGvr_MEPf68eljdFOv761-r5bpoSkaHQvvGNcRKr4SSjuuyrgCYohXUgoOz3te11Ip6SQT4UknlalpJJ4HVhBLGT9D32fvXtmabQmfTs4k2mJvl2uwzQjVhRJAdndhvM7tN8d8IeTBdyA20re0hjtlQXTIhlZJ7bTGjTYo5J_DvbkrMvgEzN2DmBib-_FU91h24d_rt5R-347j9r-tsRjd5iOlDJUpNuZL8Beg9m6Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1942678872</pqid></control><display><type>article</type><title>Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Cabantous, Sandrine ; Doumbo, Ogobara ; Poudiougou, Belco ; Louis, Laurence ; Barry, Abdoulaye ; Oumar, Aboubacar A. ; Traore, Abdoualye ; Marquet, Sandrine ; Dessein, Alain</creator><creatorcontrib>Cabantous, Sandrine ; Doumbo, Ogobara ; Poudiougou, Belco ; Louis, Laurence ; Barry, Abdoulaye ; Oumar, Aboubacar A. ; Traore, Abdoualye ; Marquet, Sandrine ; Dessein, Alain</creatorcontrib><description>Cerebral malaria, a reversible encephalopathy affecting young children, is a medical emergency requiring urgent clinical assessment and treatment. We performed a whole-transcriptomic analysis of blood samples from Malian children with cerebral or uncomplicated malaria. We focused on transcripts from pathways for which dysfunction has been associated with neurodegenerative disorders. We found that SNCA, SIAH2, UBB, HSPA1A, TUBB2A, and PINK1 were upregulated (fold-increases, ≥2.6), whereas UBD and PSMC5 were downregulated (fold-decreases, ≤4.39) in children with cerebral malaria, compared with those with uncomplicated malaria. These findings provide the first evidence for pathogenic mechanisms common to human cerebral malaria and neurodegenerative disorders.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jix359</identifier><identifier>PMID: 28934429</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; alpha-Synuclein - genetics ; alpha-Synuclein - metabolism ; ATPases Associated with Diverse Cellular Activities ; Biochemistry, Molecular Biology ; Child ; Child, Preschool ; Down-Regulation ; Female ; Gene Expression Profiling ; Genomics ; HSP70 Heat-Shock Proteins - genetics ; HSP70 Heat-Shock Proteins - metabolism ; Humans ; Leukocytes, Mononuclear - parasitology ; Life Sciences ; LIM Domain Proteins - genetics ; LIM Domain Proteins - metabolism ; Malaria, Cerebral - diagnosis ; Malaria, Cerebral - genetics ; Malaria, Falciparum - diagnosis ; Malaria, Falciparum - genetics ; Male ; Microbiology and Parasitology ; Neurodegenerative Diseases - diagnosis ; Neurodegenerative Diseases - genetics ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; PATHOGENESIS AND HOST RESPONSE ; Plasmodium falciparum ; Prospective Studies ; Proteasome Endopeptidase Complex ; Protein Kinases - genetics ; Protein Kinases - metabolism ; Reproducibility of Results ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Tubulin - genetics ; Tubulin - metabolism ; Ubiquitin - genetics ; Ubiquitin - metabolism ; Ubiquitin-Protein Ligases - genetics ; Ubiquitin-Protein Ligases - metabolism ; Ubiquitins - genetics ; Ubiquitins - metabolism ; Up-Regulation</subject><ispartof>The Journal of infectious diseases, 2017-09, Vol.216 (6), p.771-775</ispartof><rights>The Author 2017</rights><rights>The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2017</rights><rights>The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-9fcdc0a7f8687d394b5ee2815eb63edaffbb7981f706ef4878db157d7e2b01023</citedby><cites>FETCH-LOGICAL-c421t-9fcdc0a7f8687d394b5ee2815eb63edaffbb7981f706ef4878db157d7e2b01023</cites><orcidid>0000-0001-7011-6496</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26491387$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26491387$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,781,785,804,886,1585,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28934429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-01902060$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Cabantous, Sandrine</creatorcontrib><creatorcontrib>Doumbo, Ogobara</creatorcontrib><creatorcontrib>Poudiougou, Belco</creatorcontrib><creatorcontrib>Louis, Laurence</creatorcontrib><creatorcontrib>Barry, Abdoulaye</creatorcontrib><creatorcontrib>Oumar, Aboubacar A.</creatorcontrib><creatorcontrib>Traore, Abdoualye</creatorcontrib><creatorcontrib>Marquet, Sandrine</creatorcontrib><creatorcontrib>Dessein, Alain</creatorcontrib><title>Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Cerebral malaria, a reversible encephalopathy affecting young children, is a medical emergency requiring urgent clinical assessment and treatment. We performed a whole-transcriptomic analysis of blood samples from Malian children with cerebral or uncomplicated malaria. We focused on transcripts from pathways for which dysfunction has been associated with neurodegenerative disorders. We found that SNCA, SIAH2, UBB, HSPA1A, TUBB2A, and PINK1 were upregulated (fold-increases, ≥2.6), whereas UBD and PSMC5 were downregulated (fold-decreases, ≤4.39) in children with cerebral malaria, compared with those with uncomplicated malaria. These findings provide the first evidence for pathogenic mechanisms common to human cerebral malaria and neurodegenerative disorders.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>alpha-Synuclein - genetics</subject><subject>alpha-Synuclein - metabolism</subject><subject>ATPases Associated with Diverse Cellular Activities</subject><subject>Biochemistry, Molecular Biology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Genomics</subject><subject>HSP70 Heat-Shock Proteins - genetics</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear - parasitology</subject><subject>Life Sciences</subject><subject>LIM Domain Proteins - genetics</subject><subject>LIM Domain Proteins - metabolism</subject><subject>Malaria, Cerebral - diagnosis</subject><subject>Malaria, Cerebral - genetics</subject><subject>Malaria, Falciparum - diagnosis</subject><subject>Malaria, Falciparum - genetics</subject><subject>Male</subject><subject>Microbiology and Parasitology</subject><subject>Neurodegenerative Diseases - diagnosis</subject><subject>Neurodegenerative Diseases - genetics</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>PATHOGENESIS AND HOST RESPONSE</subject><subject>Plasmodium falciparum</subject><subject>Prospective Studies</subject><subject>Proteasome Endopeptidase Complex</subject><subject>Protein Kinases - genetics</subject><subject>Protein Kinases - metabolism</subject><subject>Reproducibility of Results</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Tubulin - genetics</subject><subject>Tubulin - metabolism</subject><subject>Ubiquitin - genetics</subject><subject>Ubiquitin - metabolism</subject><subject>Ubiquitin-Protein Ligases - genetics</subject><subject>Ubiquitin-Protein Ligases - metabolism</subject><subject>Ubiquitins - genetics</subject><subject>Ubiquitins - metabolism</subject><subject>Up-Regulation</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP3DAURi1UVAbaJUuQl-0i4Efix3I0pVBpAKmCteXE161HSTy1kxH8ezIKj2VXV_ru0bnS_RA6peSCEs0vQ-9dyJeb8MQrfYAWtOKyEILyT2hBCGMFVVofoeOcN4SQkgv5GR0xpXlZMr1A9hp6wFdP2wQ5h9jjZW_b5xwy_g07sG3GeyDjVey6aTtEvIIEdbItvrWtTcFi2zt8B2OKDv5MbLJD2AH-EXJMDlL-gg795IGvr_MEPf68eljdFOv761-r5bpoSkaHQvvGNcRKr4SSjuuyrgCYohXUgoOz3te11Ip6SQT4UknlalpJJ4HVhBLGT9D32fvXtmabQmfTs4k2mJvl2uwzQjVhRJAdndhvM7tN8d8IeTBdyA20re0hjtlQXTIhlZJ7bTGjTYo5J_DvbkrMvgEzN2DmBib-_FU91h24d_rt5R-347j9r-tsRjd5iOlDJUpNuZL8Beg9m6Q</recordid><startdate>20170915</startdate><enddate>20170915</enddate><creator>Cabantous, Sandrine</creator><creator>Doumbo, Ogobara</creator><creator>Poudiougou, Belco</creator><creator>Louis, Laurence</creator><creator>Barry, Abdoulaye</creator><creator>Oumar, Aboubacar A.</creator><creator>Traore, Abdoualye</creator><creator>Marquet, Sandrine</creator><creator>Dessein, Alain</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-7011-6496</orcidid></search><sort><creationdate>20170915</creationdate><title>Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders</title><author>Cabantous, Sandrine ; Doumbo, Ogobara ; Poudiougou, Belco ; Louis, Laurence ; Barry, Abdoulaye ; Oumar, Aboubacar A. ; Traore, Abdoualye ; Marquet, Sandrine ; Dessein, Alain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-9fcdc0a7f8687d394b5ee2815eb63edaffbb7981f706ef4878db157d7e2b01023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>alpha-Synuclein - genetics</topic><topic>alpha-Synuclein - metabolism</topic><topic>ATPases Associated with Diverse Cellular Activities</topic><topic>Biochemistry, Molecular Biology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Genomics</topic><topic>HSP70 Heat-Shock Proteins - genetics</topic><topic>HSP70 Heat-Shock Proteins - metabolism</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear - parasitology</topic><topic>Life Sciences</topic><topic>LIM Domain Proteins - genetics</topic><topic>LIM Domain Proteins - metabolism</topic><topic>Malaria, Cerebral - diagnosis</topic><topic>Malaria, Cerebral - genetics</topic><topic>Malaria, Falciparum - diagnosis</topic><topic>Malaria, Falciparum - genetics</topic><topic>Male</topic><topic>Microbiology and Parasitology</topic><topic>Neurodegenerative Diseases - diagnosis</topic><topic>Neurodegenerative Diseases - genetics</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>PATHOGENESIS AND HOST RESPONSE</topic><topic>Plasmodium falciparum</topic><topic>Prospective Studies</topic><topic>Proteasome Endopeptidase Complex</topic><topic>Protein Kinases - genetics</topic><topic>Protein Kinases - metabolism</topic><topic>Reproducibility of Results</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Tubulin - genetics</topic><topic>Tubulin - metabolism</topic><topic>Ubiquitin - genetics</topic><topic>Ubiquitin - metabolism</topic><topic>Ubiquitin-Protein Ligases - genetics</topic><topic>Ubiquitin-Protein Ligases - metabolism</topic><topic>Ubiquitins - genetics</topic><topic>Ubiquitins - metabolism</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cabantous, Sandrine</creatorcontrib><creatorcontrib>Doumbo, Ogobara</creatorcontrib><creatorcontrib>Poudiougou, Belco</creatorcontrib><creatorcontrib>Louis, Laurence</creatorcontrib><creatorcontrib>Barry, Abdoulaye</creatorcontrib><creatorcontrib>Oumar, Aboubacar A.</creatorcontrib><creatorcontrib>Traore, Abdoualye</creatorcontrib><creatorcontrib>Marquet, Sandrine</creatorcontrib><creatorcontrib>Dessein, Alain</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cabantous, Sandrine</au><au>Doumbo, Ogobara</au><au>Poudiougou, Belco</au><au>Louis, Laurence</au><au>Barry, Abdoulaye</au><au>Oumar, Aboubacar A.</au><au>Traore, Abdoualye</au><au>Marquet, Sandrine</au><au>Dessein, Alain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2017-09-15</date><risdate>2017</risdate><volume>216</volume><issue>6</issue><spage>771</spage><epage>775</epage><pages>771-775</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Cerebral malaria, a reversible encephalopathy affecting young children, is a medical emergency requiring urgent clinical assessment and treatment. We performed a whole-transcriptomic analysis of blood samples from Malian children with cerebral or uncomplicated malaria. We focused on transcripts from pathways for which dysfunction has been associated with neurodegenerative disorders. We found that SNCA, SIAH2, UBB, HSPA1A, TUBB2A, and PINK1 were upregulated (fold-increases, ≥2.6), whereas UBD and PSMC5 were downregulated (fold-decreases, ≤4.39) in children with cerebral malaria, compared with those with uncomplicated malaria. These findings provide the first evidence for pathogenic mechanisms common to human cerebral malaria and neurodegenerative disorders.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>28934429</pmid><doi>10.1093/infdis/jix359</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7011-6496</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2017-09, Vol.216 (6), p.771-775 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01902060v1 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism alpha-Synuclein - genetics alpha-Synuclein - metabolism ATPases Associated with Diverse Cellular Activities Biochemistry, Molecular Biology Child Child, Preschool Down-Regulation Female Gene Expression Profiling Genomics HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans Leukocytes, Mononuclear - parasitology Life Sciences LIM Domain Proteins - genetics LIM Domain Proteins - metabolism Malaria, Cerebral - diagnosis Malaria, Cerebral - genetics Malaria, Falciparum - diagnosis Malaria, Falciparum - genetics Male Microbiology and Parasitology Neurodegenerative Diseases - diagnosis Neurodegenerative Diseases - genetics Nuclear Proteins - genetics Nuclear Proteins - metabolism PATHOGENESIS AND HOST RESPONSE Plasmodium falciparum Prospective Studies Proteasome Endopeptidase Complex Protein Kinases - genetics Protein Kinases - metabolism Reproducibility of Results Transcription Factors - genetics Transcription Factors - metabolism Tubulin - genetics Tubulin - metabolism Ubiquitin - genetics Ubiquitin - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitins - genetics Ubiquitins - metabolism Up-Regulation |
| title | Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T16%3A25%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gene%20Expression%20Analysis%20Reveals%20Genes%20Common%20to%20Cerebral%20Malaria%20and%20Neurodegenerative%20Disorders&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Cabantous,%20Sandrine&rft.date=2017-09-15&rft.volume=216&rft.issue=6&rft.spage=771&rft.epage=775&rft.pages=771-775&rft.issn=0022-1899&rft.eissn=1537-6613&rft_id=info:doi/10.1093/infdis/jix359&rft_dat=%3Cjstor_hal_p%3E26491387%3C/jstor_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1942678872&rft_id=info:pmid/28934429&rft_jstor_id=26491387&rft_oup_id=10.1093/infdis/jix359&rfr_iscdi=true |