Ultra-pressure liquid chromatography–electrospray tandem mass spectrometry for multiresidue determination of pesticides in water
A multiresidue analysis method has been developed for the determination of pesticides in water by ultra-performance liquid chromatography (UPLC) combined with tandem mass spectrometry (MS/MS). The selected pesticides represent a broad range of polarity and volatility [benzoylcyclohexanedione (mesotr...
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| Veröffentlicht in: | Journal of Chromatography A 2008-08, Vol.1202 (2), p.163-172 |
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| description | A multiresidue analysis method has been developed for the determination of pesticides in water by ultra-performance liquid chromatography (UPLC) combined with tandem mass spectrometry (MS/MS). The selected pesticides represent a broad range of polarity and volatility [benzoylcyclohexanedione (mesotrione and sulcotrione); chloroacetamide (acetochlor, alachlor, dimethenamide, and metolachlor); phenoxyacetic acid (2,4-D and MCPA); phenoxypropionic (dichloprop and mecoprop); phenylurea (chlortoluron, diuron, isoproturon, linuron, and metoxuron); sulfonylurea (foramsulfuron, iodosulfuron, and nicolsulfuron); triazine (atrazine, cyanazine, desethylatrazine (DEA), desisopropylatrazine (DIA), simazine, and terbutylazine)]. The analytes were extracted using solid-phase extraction (SPE). The separation was carried out on an acquity UPLC BEH C18 column (1.7
μm, 50
mm
×
1
mm ID) using a gradient elution profile and mobile phase consisting of 0.1% formic acid in water and acetonitrile. The pesticides were detected with a tandem mass spectrometer after being ionised positively or negatively (depending on the molecule) using an electrospray ionisation (ESI) source. To achieve the suitable extraction conditions for sample preparation, several parameters affecting the efficiency of SPE such as the nature of the sorbent and the eluent, extractant volume and pH were studied. The best recovery was obtained by the extraction with an Oasis HLB cartridge and 3
mL of a solution of acetonitrile/dichloromethane (1:1, v/v) at pH 2. The average recoveries of the pesticides in different samples ranged from 82 to 109%. The weight least squares (WLS) linear regression was used to calculate the limits of detection and quantification (LOD and LOQ) because the dispersion was heteroskedastic. All the pesticides could be correctly quantified at a concentration level of 50
ng
L
−1 and most of them could be detected at a concentration inferior or equal to 8
ng
L
−1. Efficiency and robustness of this method were evaluated by the analysis of several samples of real natural water. |
| doi_str_mv | 10.1016/j.chroma.2008.07.006 |
| format | Article |
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μm, 50
mm
×
1
mm ID) using a gradient elution profile and mobile phase consisting of 0.1% formic acid in water and acetonitrile. The pesticides were detected with a tandem mass spectrometer after being ionised positively or negatively (depending on the molecule) using an electrospray ionisation (ESI) source. To achieve the suitable extraction conditions for sample preparation, several parameters affecting the efficiency of SPE such as the nature of the sorbent and the eluent, extractant volume and pH were studied. The best recovery was obtained by the extraction with an Oasis HLB cartridge and 3
mL of a solution of acetonitrile/dichloromethane (1:1, v/v) at pH 2. The average recoveries of the pesticides in different samples ranged from 82 to 109%. The weight least squares (WLS) linear regression was used to calculate the limits of detection and quantification (LOD and LOQ) because the dispersion was heteroskedastic. All the pesticides could be correctly quantified at a concentration level of 50
ng
L
−1 and most of them could be detected at a concentration inferior or equal to 8
ng
L
−1. Efficiency and robustness of this method were evaluated by the analysis of several samples of real natural water.</description><identifier>ISSN: 0021-9673</identifier><identifier>EISSN: 1873-3778</identifier><identifier>DOI: 10.1016/j.chroma.2008.07.006</identifier><identifier>PMID: 18644603</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acetonitriles - chemistry ; Analysis methods ; Analytical chemistry ; Applied sciences ; Chemical Sciences ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, High Pressure Liquid - methods ; electrospray ionization ; Environmental analysis ; Exact sciences and technology ; herbicide residues ; herbicides ; Hydrogen-Ion Concentration ; liquid chromatography ; mass spectrometry ; Methylene Chloride - chemistry ; multiresidue analysis ; Natural water pollution ; Other chromatographic methods ; pesticide residues ; Pesticide Residues - analysis ; Pesticide Residues - isolation & purification ; Pesticides ; Pesticides - analysis ; Pesticides - isolation & purification ; Pollution ; Reproducibility of Results ; Solid Phase Extraction ; Spectrometry, Mass, Electrospray Ionization - methods ; Tandem Mass Spectrometry - methods ; ultra-pressure liquid chromatography ; UPLC–MS/MS ; Water analysis ; Water Pollutants, Chemical - analysis ; Water Pollutants, Chemical - isolation & purification ; water pollution ; Water treatment and pollution</subject><ispartof>Journal of Chromatography A, 2008-08, Vol.1202 (2), p.163-172</ispartof><rights>2008 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-9c9ae95444fef834c5159b7b26fa8d8ec801b1e4606dd2072d960b0841a6b88e3</citedby><cites>FETCH-LOGICAL-c448t-9c9ae95444fef834c5159b7b26fa8d8ec801b1e4606dd2072d960b0841a6b88e3</cites><orcidid>0000-0002-9085-7985</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chroma.2008.07.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20562843$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18644603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.umontpellier.fr/hal-01897817$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Gervais, G.</creatorcontrib><creatorcontrib>Brosillon, S.</creatorcontrib><creatorcontrib>Laplanche, A.</creatorcontrib><creatorcontrib>Helen, C.</creatorcontrib><title>Ultra-pressure liquid chromatography–electrospray tandem mass spectrometry for multiresidue determination of pesticides in water</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>A multiresidue analysis method has been developed for the determination of pesticides in water by ultra-performance liquid chromatography (UPLC) combined with tandem mass spectrometry (MS/MS). The selected pesticides represent a broad range of polarity and volatility [benzoylcyclohexanedione (mesotrione and sulcotrione); chloroacetamide (acetochlor, alachlor, dimethenamide, and metolachlor); phenoxyacetic acid (2,4-D and MCPA); phenoxypropionic (dichloprop and mecoprop); phenylurea (chlortoluron, diuron, isoproturon, linuron, and metoxuron); sulfonylurea (foramsulfuron, iodosulfuron, and nicolsulfuron); triazine (atrazine, cyanazine, desethylatrazine (DEA), desisopropylatrazine (DIA), simazine, and terbutylazine)]. The analytes were extracted using solid-phase extraction (SPE). The separation was carried out on an acquity UPLC BEH C18 column (1.7
μm, 50
mm
×
1
mm ID) using a gradient elution profile and mobile phase consisting of 0.1% formic acid in water and acetonitrile. The pesticides were detected with a tandem mass spectrometer after being ionised positively or negatively (depending on the molecule) using an electrospray ionisation (ESI) source. To achieve the suitable extraction conditions for sample preparation, several parameters affecting the efficiency of SPE such as the nature of the sorbent and the eluent, extractant volume and pH were studied. The best recovery was obtained by the extraction with an Oasis HLB cartridge and 3
mL of a solution of acetonitrile/dichloromethane (1:1, v/v) at pH 2. The average recoveries of the pesticides in different samples ranged from 82 to 109%. The weight least squares (WLS) linear regression was used to calculate the limits of detection and quantification (LOD and LOQ) because the dispersion was heteroskedastic. All the pesticides could be correctly quantified at a concentration level of 50
ng
L
−1 and most of them could be detected at a concentration inferior or equal to 8
ng
L
−1. Efficiency and robustness of this method were evaluated by the analysis of several samples of real natural water.</description><subject>Acetonitriles - chemistry</subject><subject>Analysis methods</subject><subject>Analytical chemistry</subject><subject>Applied sciences</subject><subject>Chemical Sciences</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>electrospray ionization</subject><subject>Environmental analysis</subject><subject>Exact sciences and technology</subject><subject>herbicide residues</subject><subject>herbicides</subject><subject>Hydrogen-Ion Concentration</subject><subject>liquid chromatography</subject><subject>mass spectrometry</subject><subject>Methylene Chloride - chemistry</subject><subject>multiresidue analysis</subject><subject>Natural water pollution</subject><subject>Other chromatographic methods</subject><subject>pesticide residues</subject><subject>Pesticide Residues - analysis</subject><subject>Pesticide Residues - isolation & purification</subject><subject>Pesticides</subject><subject>Pesticides - analysis</subject><subject>Pesticides - isolation & purification</subject><subject>Pollution</subject><subject>Reproducibility of Results</subject><subject>Solid Phase Extraction</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>ultra-pressure liquid chromatography</subject><subject>UPLC–MS/MS</subject><subject>Water analysis</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollutants, Chemical - isolation & purification</subject><subject>water pollution</subject><subject>Water treatment and pollution</subject><issn>0021-9673</issn><issn>1873-3778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAURi0EosPAGyDwhgWLhOvEEzsbpKqiFGkkFjBry7FvOh7lD9tpNTvEK_QNeRI8ZFR2rCzde74rf4eQ1wxyBqz6cMjN3o-9zgsAmYPIAaonZMWkKLNSCPmUrAAKltWVKC_IixAOAEyAKJ6TCyYrzisoV-TXroteZ5PHEGaPtHM_ZmfpcjqOt15P--Pvnw_YoYl-DJPXRxr1YLGnvQ6Bhunvosfoj7QdPe3nLrp0ztkZqcWIvneDjm4c6NjSCUN0xlkM1A30Xqf1S_Ks1V3AV-d3TXbXn75f3WTbr5-_XF1uM8O5jFltao31hnPeYitLbjZsUzeiKapWSyvRSGANw1SrsrZIPW1dQQOSM101UmK5Ju-Xu3vdqcm7XvujGrVTN5dbdZoBk7WQTNyxxPKFNalz8Ng-Bhiok351UIsjddKvQKikP8XeLLFpbnq0_0Jn3wl4dwZ0MLprvR6MC49cAZuqkPzEvV24Vo9K3_rE7L4VwEqAuuAyIWvycSEwKbtz6FUwDgeDNsk3UdnR_f-vfwBpQbLa</recordid><startdate>20080822</startdate><enddate>20080822</enddate><creator>Gervais, G.</creator><creator>Brosillon, S.</creator><creator>Laplanche, A.</creator><creator>Helen, C.</creator><general>Elsevier B.V</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9085-7985</orcidid></search><sort><creationdate>20080822</creationdate><title>Ultra-pressure liquid chromatography–electrospray tandem mass spectrometry for multiresidue determination of pesticides in water</title><author>Gervais, G. ; Brosillon, S. ; Laplanche, A. ; Helen, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-9c9ae95444fef834c5159b7b26fa8d8ec801b1e4606dd2072d960b0841a6b88e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acetonitriles - chemistry</topic><topic>Analysis methods</topic><topic>Analytical chemistry</topic><topic>Applied sciences</topic><topic>Chemical Sciences</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>electrospray ionization</topic><topic>Environmental analysis</topic><topic>Exact sciences and technology</topic><topic>herbicide residues</topic><topic>herbicides</topic><topic>Hydrogen-Ion Concentration</topic><topic>liquid chromatography</topic><topic>mass spectrometry</topic><topic>Methylene Chloride - chemistry</topic><topic>multiresidue analysis</topic><topic>Natural water pollution</topic><topic>Other chromatographic methods</topic><topic>pesticide residues</topic><topic>Pesticide Residues - analysis</topic><topic>Pesticide Residues - isolation & purification</topic><topic>Pesticides</topic><topic>Pesticides - analysis</topic><topic>Pesticides - isolation & purification</topic><topic>Pollution</topic><topic>Reproducibility of Results</topic><topic>Solid Phase Extraction</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>ultra-pressure liquid chromatography</topic><topic>UPLC–MS/MS</topic><topic>Water analysis</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollutants, Chemical - isolation & purification</topic><topic>water pollution</topic><topic>Water treatment and pollution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gervais, G.</creatorcontrib><creatorcontrib>Brosillon, S.</creatorcontrib><creatorcontrib>Laplanche, A.</creatorcontrib><creatorcontrib>Helen, C.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gervais, G.</au><au>Brosillon, S.</au><au>Laplanche, A.</au><au>Helen, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultra-pressure liquid chromatography–electrospray tandem mass spectrometry for multiresidue determination of pesticides in water</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2008-08-22</date><risdate>2008</risdate><volume>1202</volume><issue>2</issue><spage>163</spage><epage>172</epage><pages>163-172</pages><issn>0021-9673</issn><eissn>1873-3778</eissn><coden>JOCRAM</coden><abstract>A multiresidue analysis method has been developed for the determination of pesticides in water by ultra-performance liquid chromatography (UPLC) combined with tandem mass spectrometry (MS/MS). The selected pesticides represent a broad range of polarity and volatility [benzoylcyclohexanedione (mesotrione and sulcotrione); chloroacetamide (acetochlor, alachlor, dimethenamide, and metolachlor); phenoxyacetic acid (2,4-D and MCPA); phenoxypropionic (dichloprop and mecoprop); phenylurea (chlortoluron, diuron, isoproturon, linuron, and metoxuron); sulfonylurea (foramsulfuron, iodosulfuron, and nicolsulfuron); triazine (atrazine, cyanazine, desethylatrazine (DEA), desisopropylatrazine (DIA), simazine, and terbutylazine)]. The analytes were extracted using solid-phase extraction (SPE). The separation was carried out on an acquity UPLC BEH C18 column (1.7
μm, 50
mm
×
1
mm ID) using a gradient elution profile and mobile phase consisting of 0.1% formic acid in water and acetonitrile. The pesticides were detected with a tandem mass spectrometer after being ionised positively or negatively (depending on the molecule) using an electrospray ionisation (ESI) source. To achieve the suitable extraction conditions for sample preparation, several parameters affecting the efficiency of SPE such as the nature of the sorbent and the eluent, extractant volume and pH were studied. The best recovery was obtained by the extraction with an Oasis HLB cartridge and 3
mL of a solution of acetonitrile/dichloromethane (1:1, v/v) at pH 2. The average recoveries of the pesticides in different samples ranged from 82 to 109%. The weight least squares (WLS) linear regression was used to calculate the limits of detection and quantification (LOD and LOQ) because the dispersion was heteroskedastic. All the pesticides could be correctly quantified at a concentration level of 50
ng
L
−1 and most of them could be detected at a concentration inferior or equal to 8
ng
L
−1. Efficiency and robustness of this method were evaluated by the analysis of several samples of real natural water.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18644603</pmid><doi>10.1016/j.chroma.2008.07.006</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9085-7985</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of Chromatography A, 2008-08, Vol.1202 (2), p.163-172 |
| issn | 0021-9673 1873-3778 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01897817v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetonitriles - chemistry Analysis methods Analytical chemistry Applied sciences Chemical Sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - methods electrospray ionization Environmental analysis Exact sciences and technology herbicide residues herbicides Hydrogen-Ion Concentration liquid chromatography mass spectrometry Methylene Chloride - chemistry multiresidue analysis Natural water pollution Other chromatographic methods pesticide residues Pesticide Residues - analysis Pesticide Residues - isolation & purification Pesticides Pesticides - analysis Pesticides - isolation & purification Pollution Reproducibility of Results Solid Phase Extraction Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods ultra-pressure liquid chromatography UPLC–MS/MS Water analysis Water Pollutants, Chemical - analysis Water Pollutants, Chemical - isolation & purification water pollution Water treatment and pollution |
| title | Ultra-pressure liquid chromatography–electrospray tandem mass spectrometry for multiresidue determination of pesticides in water |
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