Human papillomavirus (HPV) shedding in breast milk from African women living with HIV
•Overall, about 20% of the studied HIV-infected women shed HPV in mature breast milk.•HPV shedding may differ between the two breasts.•HPV distribution may differ between lactoserum and milk cell pellet. Little is known about human papillomavirus (HPV) shedding in human breast milk. To investigate H...
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| Veröffentlicht in: | Journal of clinical virology 2018-09, Vol.106, p.41-43 |
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| container_title | Journal of clinical virology |
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| creator | Diaz, Sophie Boulle, Nathalie Molès, Jean-Pierre Peries, Marianne Rutagwera, David Kankasa, Chipepo Tumwine, James K. Van de Perre, Philippe Segondy, Michel |
| description | •Overall, about 20% of the studied HIV-infected women shed HPV in mature breast milk.•HPV shedding may differ between the two breasts.•HPV distribution may differ between lactoserum and milk cell pellet.
Little is known about human papillomavirus (HPV) shedding in human breast milk.
To investigate HPV shedding in mature breast milk specimens collected from breastfeeding African women living with HIV-1 and not receiving antiretroviral treatment.
62 African women enrolled in the ANRS 12174 trial participated in this study. 79 lactoserum specimens obtained from right and/or left breasts from 42 Zambian women as well as lactosera and cell pellets from 40 milk samples collected from right and left breasts among 20 Ugandan women were tested for HPV using the INNO-LiPA HPV Genotyping Extra II assay.
HPV DNA was detected in 9 (11.4%) lactoserum specimens collected from 8 (19.0%) Zambian women. Fourteen (17.5%) samples from 5 (25%) Ugandan women were positive for HPV detection. Differences in HPV type identification between the two breasts as well as between lactoserum and cell pellet were oberved. Overall, 13 (21.0%) of the 62 women included in this study had detectable HPV DNA in their breast milk, representing 11 HPV types, including high-risk, probable high-risk and low-risk types.
This study confirms that HPV can be frequently detected in breast milk in HIV-infected women. Further studies are needed to understand the way by which maternal milk can shed HPV. |
| doi_str_mv | 10.1016/j.jcv.2018.07.004 |
| format | Article |
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Little is known about human papillomavirus (HPV) shedding in human breast milk.
To investigate HPV shedding in mature breast milk specimens collected from breastfeeding African women living with HIV-1 and not receiving antiretroviral treatment.
62 African women enrolled in the ANRS 12174 trial participated in this study. 79 lactoserum specimens obtained from right and/or left breasts from 42 Zambian women as well as lactosera and cell pellets from 40 milk samples collected from right and left breasts among 20 Ugandan women were tested for HPV using the INNO-LiPA HPV Genotyping Extra II assay.
HPV DNA was detected in 9 (11.4%) lactoserum specimens collected from 8 (19.0%) Zambian women. Fourteen (17.5%) samples from 5 (25%) Ugandan women were positive for HPV detection. Differences in HPV type identification between the two breasts as well as between lactoserum and cell pellet were oberved. Overall, 13 (21.0%) of the 62 women included in this study had detectable HPV DNA in their breast milk, representing 11 HPV types, including high-risk, probable high-risk and low-risk types.
This study confirms that HPV can be frequently detected in breast milk in HIV-infected women. Further studies are needed to understand the way by which maternal milk can shed HPV.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2018.07.004</identifier><identifier>PMID: 30041089</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Africa - epidemiology ; African women ; Breast Feeding ; Breast milk ; DNA, Viral - analysis ; Female ; HIV ; HIV Infections - complications ; HIV Infections - epidemiology ; HIV-1 ; HPV ; Human health and pathology ; Humans ; Infectious diseases ; Life Sciences ; Microbiology and Parasitology ; Milk, Human - virology ; Papillomaviridae - classification ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - epidemiology ; Santé publique et épidémiologie ; Uganda - epidemiology ; Virology ; Virus Shedding ; Zambia - epidemiology</subject><ispartof>Journal of clinical virology, 2018-09, Vol.106, p.41-43</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-c31c442f0fc13b98f55727b6aed044025acf86929e66ece7e9c712db798bc603</citedby><cites>FETCH-LOGICAL-c387t-c31c442f0fc13b98f55727b6aed044025acf86929e66ece7e9c712db798bc603</cites><orcidid>0000-0003-3736-5663 ; 0000-0002-0990-4722 ; 0000-0002-6863-6350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcv.2018.07.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30041089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01890085$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Diaz, Sophie</creatorcontrib><creatorcontrib>Boulle, Nathalie</creatorcontrib><creatorcontrib>Molès, Jean-Pierre</creatorcontrib><creatorcontrib>Peries, Marianne</creatorcontrib><creatorcontrib>Rutagwera, David</creatorcontrib><creatorcontrib>Kankasa, Chipepo</creatorcontrib><creatorcontrib>Tumwine, James K.</creatorcontrib><creatorcontrib>Van de Perre, Philippe</creatorcontrib><creatorcontrib>Segondy, Michel</creatorcontrib><title>Human papillomavirus (HPV) shedding in breast milk from African women living with HIV</title><title>Journal of clinical virology</title><addtitle>J Clin Virol</addtitle><description>•Overall, about 20% of the studied HIV-infected women shed HPV in mature breast milk.•HPV shedding may differ between the two breasts.•HPV distribution may differ between lactoserum and milk cell pellet.
Little is known about human papillomavirus (HPV) shedding in human breast milk.
To investigate HPV shedding in mature breast milk specimens collected from breastfeeding African women living with HIV-1 and not receiving antiretroviral treatment.
62 African women enrolled in the ANRS 12174 trial participated in this study. 79 lactoserum specimens obtained from right and/or left breasts from 42 Zambian women as well as lactosera and cell pellets from 40 milk samples collected from right and left breasts among 20 Ugandan women were tested for HPV using the INNO-LiPA HPV Genotyping Extra II assay.
HPV DNA was detected in 9 (11.4%) lactoserum specimens collected from 8 (19.0%) Zambian women. Fourteen (17.5%) samples from 5 (25%) Ugandan women were positive for HPV detection. Differences in HPV type identification between the two breasts as well as between lactoserum and cell pellet were oberved. Overall, 13 (21.0%) of the 62 women included in this study had detectable HPV DNA in their breast milk, representing 11 HPV types, including high-risk, probable high-risk and low-risk types.
This study confirms that HPV can be frequently detected in breast milk in HIV-infected women. Further studies are needed to understand the way by which maternal milk can shed HPV.</description><subject>Adult</subject><subject>Africa - epidemiology</subject><subject>African women</subject><subject>Breast Feeding</subject><subject>Breast milk</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - epidemiology</subject><subject>HIV-1</subject><subject>HPV</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>Microbiology and Parasitology</subject><subject>Milk, Human - virology</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Santé publique et épidémiologie</subject><subject>Uganda - epidemiology</subject><subject>Virology</subject><subject>Virus Shedding</subject><subject>Zambia - epidemiology</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAURi0EoqXlAdggL9vFpNd2YsdiNaqAVBoJFm23luPcMB7yM9hJKt6-jqZ0yca2rPOdxSHkE4OMAZM3h-zglowDKzNQGUD-hpyzUolNoaV6m96ilBtZCH5GPsR4AGCFyNV7ciYSy6DU5-Shmns70KM9-q4be7v4MEd6Vf18vKZxj03jh1_UD7QOaONEe9_9pm0Ye7ptg3dp-TT2ONDOLyv45Kc9re4eL8m71nYRP77cF-T-29f722qz-_H97na72zhRqimdzOU5b6F1TNS6bItCcVVLiw3kOfDCuraUmmuUEh0q1E4x3tRKl7WTIC7I9Um7t505Bt_b8NeM1ptquzPrXyqjAcpiYYm9OrHHMP6ZMU6m99Fh19kBxzkaDkpywbVeteyEujDGGLB9dTMwa3hzMCm8WcMbUCbFTJvPL_q57rF5XfwrnYAvJwBTj8VjMNF5HBw2PqCbTDP6_-ifAdGUkbY</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Diaz, Sophie</creator><creator>Boulle, Nathalie</creator><creator>Molès, Jean-Pierre</creator><creator>Peries, Marianne</creator><creator>Rutagwera, David</creator><creator>Kankasa, Chipepo</creator><creator>Tumwine, James K.</creator><creator>Van de Perre, Philippe</creator><creator>Segondy, Michel</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-3736-5663</orcidid><orcidid>https://orcid.org/0000-0002-0990-4722</orcidid><orcidid>https://orcid.org/0000-0002-6863-6350</orcidid></search><sort><creationdate>20180901</creationdate><title>Human papillomavirus (HPV) shedding in breast milk from African women living with HIV</title><author>Diaz, Sophie ; Boulle, Nathalie ; Molès, Jean-Pierre ; Peries, Marianne ; Rutagwera, David ; Kankasa, Chipepo ; Tumwine, James K. ; Van de Perre, Philippe ; Segondy, Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-c31c442f0fc13b98f55727b6aed044025acf86929e66ece7e9c712db798bc603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Africa - epidemiology</topic><topic>African women</topic><topic>Breast Feeding</topic><topic>Breast milk</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - epidemiology</topic><topic>HIV-1</topic><topic>HPV</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Life Sciences</topic><topic>Microbiology and Parasitology</topic><topic>Milk, Human - virology</topic><topic>Papillomaviridae - classification</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Santé publique et épidémiologie</topic><topic>Uganda - epidemiology</topic><topic>Virology</topic><topic>Virus Shedding</topic><topic>Zambia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diaz, Sophie</creatorcontrib><creatorcontrib>Boulle, Nathalie</creatorcontrib><creatorcontrib>Molès, Jean-Pierre</creatorcontrib><creatorcontrib>Peries, Marianne</creatorcontrib><creatorcontrib>Rutagwera, David</creatorcontrib><creatorcontrib>Kankasa, Chipepo</creatorcontrib><creatorcontrib>Tumwine, James K.</creatorcontrib><creatorcontrib>Van de Perre, Philippe</creatorcontrib><creatorcontrib>Segondy, Michel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diaz, Sophie</au><au>Boulle, Nathalie</au><au>Molès, Jean-Pierre</au><au>Peries, Marianne</au><au>Rutagwera, David</au><au>Kankasa, Chipepo</au><au>Tumwine, James K.</au><au>Van de Perre, Philippe</au><au>Segondy, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human papillomavirus (HPV) shedding in breast milk from African women living with HIV</atitle><jtitle>Journal of clinical virology</jtitle><addtitle>J Clin Virol</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>106</volume><spage>41</spage><epage>43</epage><pages>41-43</pages><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>•Overall, about 20% of the studied HIV-infected women shed HPV in mature breast milk.•HPV shedding may differ between the two breasts.•HPV distribution may differ between lactoserum and milk cell pellet.
Little is known about human papillomavirus (HPV) shedding in human breast milk.
To investigate HPV shedding in mature breast milk specimens collected from breastfeeding African women living with HIV-1 and not receiving antiretroviral treatment.
62 African women enrolled in the ANRS 12174 trial participated in this study. 79 lactoserum specimens obtained from right and/or left breasts from 42 Zambian women as well as lactosera and cell pellets from 40 milk samples collected from right and left breasts among 20 Ugandan women were tested for HPV using the INNO-LiPA HPV Genotyping Extra II assay.
HPV DNA was detected in 9 (11.4%) lactoserum specimens collected from 8 (19.0%) Zambian women. Fourteen (17.5%) samples from 5 (25%) Ugandan women were positive for HPV detection. Differences in HPV type identification between the two breasts as well as between lactoserum and cell pellet were oberved. Overall, 13 (21.0%) of the 62 women included in this study had detectable HPV DNA in their breast milk, representing 11 HPV types, including high-risk, probable high-risk and low-risk types.
This study confirms that HPV can be frequently detected in breast milk in HIV-infected women. Further studies are needed to understand the way by which maternal milk can shed HPV.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30041089</pmid><doi>10.1016/j.jcv.2018.07.004</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-3736-5663</orcidid><orcidid>https://orcid.org/0000-0002-0990-4722</orcidid><orcidid>https://orcid.org/0000-0002-6863-6350</orcidid></addata></record> |
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| ispartof | Journal of clinical virology, 2018-09, Vol.106, p.41-43 |
| issn | 1386-6532 1873-5967 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01890085v1 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Africa - epidemiology African women Breast Feeding Breast milk DNA, Viral - analysis Female HIV HIV Infections - complications HIV Infections - epidemiology HIV-1 HPV Human health and pathology Humans Infectious diseases Life Sciences Microbiology and Parasitology Milk, Human - virology Papillomaviridae - classification Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - epidemiology Santé publique et épidémiologie Uganda - epidemiology Virology Virus Shedding Zambia - epidemiology |
| title | Human papillomavirus (HPV) shedding in breast milk from African women living with HIV |
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