Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study
Background Autonomic nervous system (ANS) activity has been suggested to modulate the clinical severity of sickle cell anemia (SCA) by increasing the risk for vaso‐occlusive events. Regular physical activity (PA) is known to improve ANS activity and health status in several cardiovascular and metabo...
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| Veröffentlicht in: | Pediatric blood & cancer 2015-11, Vol.62 (11), p.1962-1967 |
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| container_title | Pediatric blood & cancer |
| container_volume | 62 |
| creator | Charlot, Keyne Moeckesch, Berenike Jumet, Stéphane Romana, Marc Waltz, Xavier Divialle-Doumdo, Lydia Hardy-Dessources, Marie-Dominique Petras, Marie Tressières, Benoît Pichon, Aurélien Tarer, Vanessa Hue, Olivier Etienne-Julan, Maryse Antoine-Jonville, Sophie Connes, Philippe |
| description | Background
Autonomic nervous system (ANS) activity has been suggested to modulate the clinical severity of sickle cell anemia (SCA) by increasing the risk for vaso‐occlusive events. Regular physical activity (PA) is known to improve ANS activity and health status in several cardiovascular and metabolic diseases. Whether regular PA improves the health status of SCA patients remains unknown.
Procedure
Twenty‐two patients with SCA and 15 healthy (AA) children/adolescents participated to the study. Heart rate variability was measured in supine position and after a tilt‐test to quantify the ANS activity. PA energy expenditure (PAEE) was assessed with questionnaire.
Results
1) PAEE was lower in SCA compared to AA (190 ± 152 vs. 432 ± 277 kcal·d−1, respectively, P |
| doi_str_mv | 10.1002/pbc.25604 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01881497v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1753491056</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4914-f3a6bfa8415b5668063133227c398049bb5aa58790f5ecb6ab5c620f447bd8703</originalsourceid><addsrcrecordid>eNqNks1u1DAUhSMEoqWw4AWQJTawSMf_sdkNI2gRI2hFgaXlOI7GreNMY2dKXojnxNNppxISEitbV989Osc-RfESwWMEIZ6ta3OMGYf0UXGIGGUlg6h6vL9DeVA8i_Eyoxwy8bQ4wEwKKaE4LH6frabojPZAm-Q2Lk3A2431wEUQ-gQ0aGyyQ-eCDgn0LdBj6kPfOQOCHTb9GEGcYrLdw74ODTDehVvVmMWG7dQFYFbON4MNM9303kZjQ4rgxqUVyA6uvAXG-uwj2M7pd2AO1s5nBzGNzfS8eNJqH-2Lu_Oo-P7xw8XitFx-Pfm0mC9LQyWiZUs0r1stKGI141xAThAhGFeGSAGprGumNROVhC2zpua6ZoZj2FJa1Y2oIDkq3u50V9qr9eA6PUyq106dzpdqO4NICERltUGZfbNj10N_PdqYVOfiNkJOkN9FoYqR7Aoy_h8o4pIIinFGX_-FXvbjEHJohSFhnEoM8YNPM_QxDrbdm0VQbTuhcifUbScy--pOcaw72-zJ-xJkYLYDbpy307-V1Nn7xb1kudtw-et_7Tf0cKV4RSqmfn45UfLb-We-_HGuLsgfgc7QZQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2035649202</pqid></control><display><type>article</type><title>Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study</title><source>MEDLINE</source><source>Wiley Blackwell Single Titles</source><creator>Charlot, Keyne ; Moeckesch, Berenike ; Jumet, Stéphane ; Romana, Marc ; Waltz, Xavier ; Divialle-Doumdo, Lydia ; Hardy-Dessources, Marie-Dominique ; Petras, Marie ; Tressières, Benoît ; Pichon, Aurélien ; Tarer, Vanessa ; Hue, Olivier ; Etienne-Julan, Maryse ; Antoine-Jonville, Sophie ; Connes, Philippe</creator><creatorcontrib>Charlot, Keyne ; Moeckesch, Berenike ; Jumet, Stéphane ; Romana, Marc ; Waltz, Xavier ; Divialle-Doumdo, Lydia ; Hardy-Dessources, Marie-Dominique ; Petras, Marie ; Tressières, Benoît ; Pichon, Aurélien ; Tarer, Vanessa ; Hue, Olivier ; Etienne-Julan, Maryse ; Antoine-Jonville, Sophie ; Connes, Philippe</creatorcontrib><description>Background
Autonomic nervous system (ANS) activity has been suggested to modulate the clinical severity of sickle cell anemia (SCA) by increasing the risk for vaso‐occlusive events. Regular physical activity (PA) is known to improve ANS activity and health status in several cardiovascular and metabolic diseases. Whether regular PA improves the health status of SCA patients remains unknown.
Procedure
Twenty‐two patients with SCA and 15 healthy (AA) children/adolescents participated to the study. Heart rate variability was measured in supine position and after a tilt‐test to quantify the ANS activity. PA energy expenditure (PAEE) was assessed with questionnaire.
Results
1) PAEE was lower in SCA compared to AA (190 ± 152 vs. 432 ± 277 kcal·d−1, respectively, P < 0.01), 2) overall ANS activity was lower in SCA compared to AA, 3) parasympathetic withdrawal was observed in SCA with aging, 4) ANS reactivity was slightly impaired in SCA compared to AA (reduction in HFnu: −38 ± 27 vs. −58 ± 14%, respectively, P < 0.05), 5) ANS indices, PAEE, and rates of clinical events were not correlated.
Conclusion
Both the level of PA and ANS activity are reduced in SCA compared to AA children/adolescents, particularly in those older than 15 years. Neither PAEE, nor ANS activity seem to influence the clinical severity of children/adolescents with SCA. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.25604</identifier><identifier>PMID: 25989908</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>acute chest syndrome ; Adolescent ; Adolescents ; Age Factors ; Aging ; Anemia ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - physiopathology ; Anemia, Sickle Cell - therapy ; Arterial Occlusive Diseases - etiology ; Arterial Occlusive Diseases - physiopathology ; Arterial Occlusive Diseases - therapy ; Autonomic nervous system ; Autonomic Nervous System - physiopathology ; Cancer ; Child ; Children ; Energy expenditure ; Exercise ; Female ; Health Status ; Heart rate ; heart rate variability ; Hematology ; Humans ; Life Sciences ; Male ; Metabolic disorders ; Motor Activity ; Nervous system ; Oncology ; Parasympathetic nervous system ; Pediatrics ; Physical activity ; physical activity energy expenditure ; Pilot Projects ; Position measurement ; Quality of Life ; Sickle cell anemia ; Sickle cell disease ; Supine position ; Teenagers ; vaso-occlusive crises</subject><ispartof>Pediatric blood & cancer, 2015-11, Vol.62 (11), p.1962-1967</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4914-f3a6bfa8415b5668063133227c398049bb5aa58790f5ecb6ab5c620f447bd8703</citedby><cites>FETCH-LOGICAL-c4914-f3a6bfa8415b5668063133227c398049bb5aa58790f5ecb6ab5c620f447bd8703</cites><orcidid>0000-0002-2155-0816 ; 0000-0003-2772-9232 ; 0000-0002-8715-9836 ; 0000-0003-0691-2177 ; 0000-0002-4366-4013 ; 0000-0002-9232-0268 ; 0000-0002-9585-4281</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.25604$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.25604$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25989908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-lyon1.hal.science/hal-01881497$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Charlot, Keyne</creatorcontrib><creatorcontrib>Moeckesch, Berenike</creatorcontrib><creatorcontrib>Jumet, Stéphane</creatorcontrib><creatorcontrib>Romana, Marc</creatorcontrib><creatorcontrib>Waltz, Xavier</creatorcontrib><creatorcontrib>Divialle-Doumdo, Lydia</creatorcontrib><creatorcontrib>Hardy-Dessources, Marie-Dominique</creatorcontrib><creatorcontrib>Petras, Marie</creatorcontrib><creatorcontrib>Tressières, Benoît</creatorcontrib><creatorcontrib>Pichon, Aurélien</creatorcontrib><creatorcontrib>Tarer, Vanessa</creatorcontrib><creatorcontrib>Hue, Olivier</creatorcontrib><creatorcontrib>Etienne-Julan, Maryse</creatorcontrib><creatorcontrib>Antoine-Jonville, Sophie</creatorcontrib><creatorcontrib>Connes, Philippe</creatorcontrib><title>Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study</title><title>Pediatric blood & cancer</title><addtitle>Pediatr Blood Cancer</addtitle><description>Background
Autonomic nervous system (ANS) activity has been suggested to modulate the clinical severity of sickle cell anemia (SCA) by increasing the risk for vaso‐occlusive events. Regular physical activity (PA) is known to improve ANS activity and health status in several cardiovascular and metabolic diseases. Whether regular PA improves the health status of SCA patients remains unknown.
Procedure
Twenty‐two patients with SCA and 15 healthy (AA) children/adolescents participated to the study. Heart rate variability was measured in supine position and after a tilt‐test to quantify the ANS activity. PA energy expenditure (PAEE) was assessed with questionnaire.
Results
1) PAEE was lower in SCA compared to AA (190 ± 152 vs. 432 ± 277 kcal·d−1, respectively, P < 0.01), 2) overall ANS activity was lower in SCA compared to AA, 3) parasympathetic withdrawal was observed in SCA with aging, 4) ANS reactivity was slightly impaired in SCA compared to AA (reduction in HFnu: −38 ± 27 vs. −58 ± 14%, respectively, P < 0.05), 5) ANS indices, PAEE, and rates of clinical events were not correlated.
Conclusion
Both the level of PA and ANS activity are reduced in SCA compared to AA children/adolescents, particularly in those older than 15 years. Neither PAEE, nor ANS activity seem to influence the clinical severity of children/adolescents with SCA. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.</description><subject>acute chest syndrome</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Age Factors</subject><subject>Aging</subject><subject>Anemia</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - physiopathology</subject><subject>Anemia, Sickle Cell - therapy</subject><subject>Arterial Occlusive Diseases - etiology</subject><subject>Arterial Occlusive Diseases - physiopathology</subject><subject>Arterial Occlusive Diseases - therapy</subject><subject>Autonomic nervous system</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Cancer</subject><subject>Child</subject><subject>Children</subject><subject>Energy expenditure</subject><subject>Exercise</subject><subject>Female</subject><subject>Health Status</subject><subject>Heart rate</subject><subject>heart rate variability</subject><subject>Hematology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Motor Activity</subject><subject>Nervous system</subject><subject>Oncology</subject><subject>Parasympathetic nervous system</subject><subject>Pediatrics</subject><subject>Physical activity</subject><subject>physical activity energy expenditure</subject><subject>Pilot Projects</subject><subject>Position measurement</subject><subject>Quality of Life</subject><subject>Sickle cell anemia</subject><subject>Sickle cell disease</subject><subject>Supine position</subject><subject>Teenagers</subject><subject>vaso-occlusive crises</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhSMEoqWw4AWQJTawSMf_sdkNI2gRI2hFgaXlOI7GreNMY2dKXojnxNNppxISEitbV989Osc-RfESwWMEIZ6ta3OMGYf0UXGIGGUlg6h6vL9DeVA8i_Eyoxwy8bQ4wEwKKaE4LH6frabojPZAm-Q2Lk3A2431wEUQ-gQ0aGyyQ-eCDgn0LdBj6kPfOQOCHTb9GEGcYrLdw74ODTDehVvVmMWG7dQFYFbON4MNM9303kZjQ4rgxqUVyA6uvAXG-uwj2M7pd2AO1s5nBzGNzfS8eNJqH-2Lu_Oo-P7xw8XitFx-Pfm0mC9LQyWiZUs0r1stKGI141xAThAhGFeGSAGprGumNROVhC2zpua6ZoZj2FJa1Y2oIDkq3u50V9qr9eA6PUyq106dzpdqO4NICERltUGZfbNj10N_PdqYVOfiNkJOkN9FoYqR7Aoy_h8o4pIIinFGX_-FXvbjEHJohSFhnEoM8YNPM_QxDrbdm0VQbTuhcifUbScy--pOcaw72-zJ-xJkYLYDbpy307-V1Nn7xb1kudtw-et_7Tf0cKV4RSqmfn45UfLb-We-_HGuLsgfgc7QZQ</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Charlot, Keyne</creator><creator>Moeckesch, Berenike</creator><creator>Jumet, Stéphane</creator><creator>Romana, Marc</creator><creator>Waltz, Xavier</creator><creator>Divialle-Doumdo, Lydia</creator><creator>Hardy-Dessources, Marie-Dominique</creator><creator>Petras, Marie</creator><creator>Tressières, Benoît</creator><creator>Pichon, Aurélien</creator><creator>Tarer, Vanessa</creator><creator>Hue, Olivier</creator><creator>Etienne-Julan, Maryse</creator><creator>Antoine-Jonville, Sophie</creator><creator>Connes, Philippe</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2155-0816</orcidid><orcidid>https://orcid.org/0000-0003-2772-9232</orcidid><orcidid>https://orcid.org/0000-0002-8715-9836</orcidid><orcidid>https://orcid.org/0000-0003-0691-2177</orcidid><orcidid>https://orcid.org/0000-0002-4366-4013</orcidid><orcidid>https://orcid.org/0000-0002-9232-0268</orcidid><orcidid>https://orcid.org/0000-0002-9585-4281</orcidid></search><sort><creationdate>201511</creationdate><title>Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study</title><author>Charlot, Keyne ; Moeckesch, Berenike ; Jumet, Stéphane ; Romana, Marc ; Waltz, Xavier ; Divialle-Doumdo, Lydia ; Hardy-Dessources, Marie-Dominique ; Petras, Marie ; Tressières, Benoît ; Pichon, Aurélien ; Tarer, Vanessa ; Hue, Olivier ; Etienne-Julan, Maryse ; Antoine-Jonville, Sophie ; Connes, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4914-f3a6bfa8415b5668063133227c398049bb5aa58790f5ecb6ab5c620f447bd8703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>acute chest syndrome</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Age Factors</topic><topic>Aging</topic><topic>Anemia</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - physiopathology</topic><topic>Anemia, Sickle Cell - therapy</topic><topic>Arterial Occlusive Diseases - etiology</topic><topic>Arterial Occlusive Diseases - physiopathology</topic><topic>Arterial Occlusive Diseases - therapy</topic><topic>Autonomic nervous system</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Cancer</topic><topic>Child</topic><topic>Children</topic><topic>Energy expenditure</topic><topic>Exercise</topic><topic>Female</topic><topic>Health Status</topic><topic>Heart rate</topic><topic>heart rate variability</topic><topic>Hematology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Motor Activity</topic><topic>Nervous system</topic><topic>Oncology</topic><topic>Parasympathetic nervous system</topic><topic>Pediatrics</topic><topic>Physical activity</topic><topic>physical activity energy expenditure</topic><topic>Pilot Projects</topic><topic>Position measurement</topic><topic>Quality of Life</topic><topic>Sickle cell anemia</topic><topic>Sickle cell disease</topic><topic>Supine position</topic><topic>Teenagers</topic><topic>vaso-occlusive crises</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Charlot, Keyne</creatorcontrib><creatorcontrib>Moeckesch, Berenike</creatorcontrib><creatorcontrib>Jumet, Stéphane</creatorcontrib><creatorcontrib>Romana, Marc</creatorcontrib><creatorcontrib>Waltz, Xavier</creatorcontrib><creatorcontrib>Divialle-Doumdo, Lydia</creatorcontrib><creatorcontrib>Hardy-Dessources, Marie-Dominique</creatorcontrib><creatorcontrib>Petras, Marie</creatorcontrib><creatorcontrib>Tressières, Benoît</creatorcontrib><creatorcontrib>Pichon, Aurélien</creatorcontrib><creatorcontrib>Tarer, Vanessa</creatorcontrib><creatorcontrib>Hue, Olivier</creatorcontrib><creatorcontrib>Etienne-Julan, Maryse</creatorcontrib><creatorcontrib>Antoine-Jonville, Sophie</creatorcontrib><creatorcontrib>Connes, Philippe</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Charlot, Keyne</au><au>Moeckesch, Berenike</au><au>Jumet, Stéphane</au><au>Romana, Marc</au><au>Waltz, Xavier</au><au>Divialle-Doumdo, Lydia</au><au>Hardy-Dessources, Marie-Dominique</au><au>Petras, Marie</au><au>Tressières, Benoît</au><au>Pichon, Aurélien</au><au>Tarer, Vanessa</au><au>Hue, Olivier</au><au>Etienne-Julan, Maryse</au><au>Antoine-Jonville, Sophie</au><au>Connes, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr Blood Cancer</addtitle><date>2015-11</date><risdate>2015</risdate><volume>62</volume><issue>11</issue><spage>1962</spage><epage>1967</epage><pages>1962-1967</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Background
Autonomic nervous system (ANS) activity has been suggested to modulate the clinical severity of sickle cell anemia (SCA) by increasing the risk for vaso‐occlusive events. Regular physical activity (PA) is known to improve ANS activity and health status in several cardiovascular and metabolic diseases. Whether regular PA improves the health status of SCA patients remains unknown.
Procedure
Twenty‐two patients with SCA and 15 healthy (AA) children/adolescents participated to the study. Heart rate variability was measured in supine position and after a tilt‐test to quantify the ANS activity. PA energy expenditure (PAEE) was assessed with questionnaire.
Results
1) PAEE was lower in SCA compared to AA (190 ± 152 vs. 432 ± 277 kcal·d−1, respectively, P < 0.01), 2) overall ANS activity was lower in SCA compared to AA, 3) parasympathetic withdrawal was observed in SCA with aging, 4) ANS reactivity was slightly impaired in SCA compared to AA (reduction in HFnu: −38 ± 27 vs. −58 ± 14%, respectively, P < 0.05), 5) ANS indices, PAEE, and rates of clinical events were not correlated.
Conclusion
Both the level of PA and ANS activity are reduced in SCA compared to AA children/adolescents, particularly in those older than 15 years. Neither PAEE, nor ANS activity seem to influence the clinical severity of children/adolescents with SCA. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25989908</pmid><doi>10.1002/pbc.25604</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2155-0816</orcidid><orcidid>https://orcid.org/0000-0003-2772-9232</orcidid><orcidid>https://orcid.org/0000-0002-8715-9836</orcidid><orcidid>https://orcid.org/0000-0003-0691-2177</orcidid><orcidid>https://orcid.org/0000-0002-4366-4013</orcidid><orcidid>https://orcid.org/0000-0002-9232-0268</orcidid><orcidid>https://orcid.org/0000-0002-9585-4281</orcidid></addata></record> |
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| subjects | acute chest syndrome Adolescent Adolescents Age Factors Aging Anemia Anemia, Sickle Cell - complications Anemia, Sickle Cell - physiopathology Anemia, Sickle Cell - therapy Arterial Occlusive Diseases - etiology Arterial Occlusive Diseases - physiopathology Arterial Occlusive Diseases - therapy Autonomic nervous system Autonomic Nervous System - physiopathology Cancer Child Children Energy expenditure Exercise Female Health Status Heart rate heart rate variability Hematology Humans Life Sciences Male Metabolic disorders Motor Activity Nervous system Oncology Parasympathetic nervous system Pediatrics Physical activity physical activity energy expenditure Pilot Projects Position measurement Quality of Life Sickle cell anemia Sickle cell disease Supine position Teenagers vaso-occlusive crises |
| title | Physical activity level is not a determinant of autonomic nervous system activity and clinical severity in children/adolescents with sickle cell anemia: A pilot study |
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