The Effect of Hydrophile Topology in RAFT-Mediated Polymerization-Induced Self-Assembly
Polymerization‐induced self‐assembly (PISA) was employed to compare the self‐assembly of different amphiphilic block copolymers. They were obtained by emulsion polymerization of styrene in water using hydrophilic poly(N‐acryloylmorpholine) (PNAM)‐based macromolecular RAFT agents with different struc...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2016-03, Vol.55 (11), p.3739-3743 |
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| creator | Lesage de la Haye, Jennifer Zhang, Xuewei Chaduc, Isabelle Brunel, Fabrice Lansalot, Muriel D'Agosto, Franck |
| description | Polymerization‐induced self‐assembly (PISA) was employed to compare the self‐assembly of different amphiphilic block copolymers. They were obtained by emulsion polymerization of styrene in water using hydrophilic poly(N‐acryloylmorpholine) (PNAM)‐based macromolecular RAFT agents with different structures. An average of three poly (ethylene glycol acrylate) (PEGA) units were introduced either at the beginning, statistically, or at the end of a PNAM backbone, resulting in formation of nanometric vesicles and spheres from the two former macroRAFT architectures, and large vesicles from the latter. Compared to the spheres obtained with a pure PNAM macroRAFT agent, composite macroRAFT architectures promoted a dramatic morphological change. The change was induced by the presence of PEGA hydrophilic side‐chains close to the hydrophobic polystyrene segment.
An average of three PEGA units were introduced either at the beginning, statistically, or at the end of a hydrophilic segment, resulting in formation of various block copolymer morphologies. Key: a) Same hydrophilic comonomers; b) various hydrophilic macroRAFTs; c) different particle morphologies (spheres, nanovesicles, large vesicles), N‐acryloyl morpholine (• (blue)), PEG acrylate (•••• (green)). |
| doi_str_mv | 10.1002/anie.201511159 |
| format | Article |
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An average of three PEGA units were introduced either at the beginning, statistically, or at the end of a hydrophilic segment, resulting in formation of various block copolymer morphologies. Key: a) Same hydrophilic comonomers; b) various hydrophilic macroRAFTs; c) different particle morphologies (spheres, nanovesicles, large vesicles), N‐acryloyl morpholine (• (blue)), PEG acrylate (•••• (green)).</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201511159</identifier><identifier>PMID: 26880016</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>amphiphiles ; Backbone ; Block copolymers ; Chains (polymeric) ; Chemical Sciences ; Copolymers ; Emulsion polymerization ; Ethylene glycol ; Hydrophobicity ; Macromolecules ; nanoparticles ; Nanostructure ; Polyethylene glycol ; Polymerization ; Polystyrene ; Polystyrene resins ; RAFT polymerization ; Self-assembly ; Styrene ; Topology ; Vesicles ; water</subject><ispartof>Angewandte Chemie International Edition, 2016-03, Vol.55 (11), p.3739-3743</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6469-40ca49fff2d3e84a32d07fb0e9c34fc83fa06638ec2c03124ebce1614a18c0873</citedby><cites>FETCH-LOGICAL-c6469-40ca49fff2d3e84a32d07fb0e9c34fc83fa06638ec2c03124ebce1614a18c0873</cites><orcidid>0000-0002-0659-7229 ; 0000-0001-9010-6746 ; 0000-0003-2730-869X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201511159$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201511159$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26880016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01877395$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lesage de la Haye, Jennifer</creatorcontrib><creatorcontrib>Zhang, Xuewei</creatorcontrib><creatorcontrib>Chaduc, Isabelle</creatorcontrib><creatorcontrib>Brunel, Fabrice</creatorcontrib><creatorcontrib>Lansalot, Muriel</creatorcontrib><creatorcontrib>D'Agosto, Franck</creatorcontrib><title>The Effect of Hydrophile Topology in RAFT-Mediated Polymerization-Induced Self-Assembly</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>Polymerization‐induced self‐assembly (PISA) was employed to compare the self‐assembly of different amphiphilic block copolymers. They were obtained by emulsion polymerization of styrene in water using hydrophilic poly(N‐acryloylmorpholine) (PNAM)‐based macromolecular RAFT agents with different structures. An average of three poly (ethylene glycol acrylate) (PEGA) units were introduced either at the beginning, statistically, or at the end of a PNAM backbone, resulting in formation of nanometric vesicles and spheres from the two former macroRAFT architectures, and large vesicles from the latter. Compared to the spheres obtained with a pure PNAM macroRAFT agent, composite macroRAFT architectures promoted a dramatic morphological change. The change was induced by the presence of PEGA hydrophilic side‐chains close to the hydrophobic polystyrene segment.
An average of three PEGA units were introduced either at the beginning, statistically, or at the end of a hydrophilic segment, resulting in formation of various block copolymer morphologies. Key: a) Same hydrophilic comonomers; b) various hydrophilic macroRAFTs; c) different particle morphologies (spheres, nanovesicles, large vesicles), N‐acryloyl morpholine (• (blue)), PEG acrylate (•••• (green)).</description><subject>amphiphiles</subject><subject>Backbone</subject><subject>Block copolymers</subject><subject>Chains (polymeric)</subject><subject>Chemical Sciences</subject><subject>Copolymers</subject><subject>Emulsion polymerization</subject><subject>Ethylene glycol</subject><subject>Hydrophobicity</subject><subject>Macromolecules</subject><subject>nanoparticles</subject><subject>Nanostructure</subject><subject>Polyethylene glycol</subject><subject>Polymerization</subject><subject>Polystyrene</subject><subject>Polystyrene resins</subject><subject>RAFT polymerization</subject><subject>Self-assembly</subject><subject>Styrene</subject><subject>Topology</subject><subject>Vesicles</subject><subject>water</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkUGP0zAQhSMEYpeFK0cUiQscUjyxYzvH7KrbVioLWop6tFxnTLMkcTdOgPDrcZWlQhzgNKPR996M_aLoJZAZEJK-022Fs5RABgBZ_ig6hyyFhApBH4eeUZoImcFZ9Mz7u8BLSfjT6CzloSHAz6PtZo_x3Fo0fexsvBzLzh32VY3xxh1c7b6McdXGt8X1JnmPZaV7LOOPrh4b7Kqfuq9cm6zacjBh_AlrmxTeY7Orx-fRE6trjy8e6kX0-Xq-uVom6w-L1VWxTgxnPE8YMZrl1tq0pCiZpmlJhN0RzA1l1khqNeGcSjSpIRRShjuDwIFpkIZIQS-it5PvXtfq0FWN7kbldKWWxVodZwRk-Iw8-waBfTOxh87dD-h71VTeYF3rFt3gFQie55JSwgL6-i_0zg1dG16iIA8XccJT8U9KcMkBaHZcO5so0znvO7SnO4GoY4jqGKI6hRgErx5sh12D5Qn_nVoA8gn4HoIa_2OnipvV_E_zZNJWvscfJ63uviouqMjU9mah2OXill4ut0rSX4r-tJU</recordid><startdate>20160307</startdate><enddate>20160307</enddate><creator>Lesage de la Haye, Jennifer</creator><creator>Zhang, Xuewei</creator><creator>Chaduc, Isabelle</creator><creator>Brunel, Fabrice</creator><creator>Lansalot, Muriel</creator><creator>D'Agosto, Franck</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>Wiley-VCH Verlag</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0659-7229</orcidid><orcidid>https://orcid.org/0000-0001-9010-6746</orcidid><orcidid>https://orcid.org/0000-0003-2730-869X</orcidid></search><sort><creationdate>20160307</creationdate><title>The Effect of Hydrophile Topology in RAFT-Mediated Polymerization-Induced Self-Assembly</title><author>Lesage de la Haye, Jennifer ; Zhang, Xuewei ; Chaduc, Isabelle ; Brunel, Fabrice ; Lansalot, Muriel ; D'Agosto, Franck</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6469-40ca49fff2d3e84a32d07fb0e9c34fc83fa06638ec2c03124ebce1614a18c0873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>amphiphiles</topic><topic>Backbone</topic><topic>Block copolymers</topic><topic>Chains (polymeric)</topic><topic>Chemical Sciences</topic><topic>Copolymers</topic><topic>Emulsion polymerization</topic><topic>Ethylene glycol</topic><topic>Hydrophobicity</topic><topic>Macromolecules</topic><topic>nanoparticles</topic><topic>Nanostructure</topic><topic>Polyethylene glycol</topic><topic>Polymerization</topic><topic>Polystyrene</topic><topic>Polystyrene resins</topic><topic>RAFT polymerization</topic><topic>Self-assembly</topic><topic>Styrene</topic><topic>Topology</topic><topic>Vesicles</topic><topic>water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lesage de la Haye, Jennifer</creatorcontrib><creatorcontrib>Zhang, Xuewei</creatorcontrib><creatorcontrib>Chaduc, Isabelle</creatorcontrib><creatorcontrib>Brunel, Fabrice</creatorcontrib><creatorcontrib>Lansalot, Muriel</creatorcontrib><creatorcontrib>D'Agosto, Franck</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lesage de la Haye, Jennifer</au><au>Zhang, Xuewei</au><au>Chaduc, Isabelle</au><au>Brunel, Fabrice</au><au>Lansalot, Muriel</au><au>D'Agosto, Franck</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Hydrophile Topology in RAFT-Mediated Polymerization-Induced Self-Assembly</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2016-03-07</date><risdate>2016</risdate><volume>55</volume><issue>11</issue><spage>3739</spage><epage>3743</epage><pages>3739-3743</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>Polymerization‐induced self‐assembly (PISA) was employed to compare the self‐assembly of different amphiphilic block copolymers. They were obtained by emulsion polymerization of styrene in water using hydrophilic poly(N‐acryloylmorpholine) (PNAM)‐based macromolecular RAFT agents with different structures. An average of three poly (ethylene glycol acrylate) (PEGA) units were introduced either at the beginning, statistically, or at the end of a PNAM backbone, resulting in formation of nanometric vesicles and spheres from the two former macroRAFT architectures, and large vesicles from the latter. Compared to the spheres obtained with a pure PNAM macroRAFT agent, composite macroRAFT architectures promoted a dramatic morphological change. The change was induced by the presence of PEGA hydrophilic side‐chains close to the hydrophobic polystyrene segment.
An average of three PEGA units were introduced either at the beginning, statistically, or at the end of a hydrophilic segment, resulting in formation of various block copolymer morphologies. Key: a) Same hydrophilic comonomers; b) various hydrophilic macroRAFTs; c) different particle morphologies (spheres, nanovesicles, large vesicles), N‐acryloyl morpholine (• (blue)), PEG acrylate (•••• (green)).</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26880016</pmid><doi>10.1002/anie.201511159</doi><tpages>5</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0002-0659-7229</orcidid><orcidid>https://orcid.org/0000-0001-9010-6746</orcidid><orcidid>https://orcid.org/0000-0003-2730-869X</orcidid></addata></record> |
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| subjects | amphiphiles Backbone Block copolymers Chains (polymeric) Chemical Sciences Copolymers Emulsion polymerization Ethylene glycol Hydrophobicity Macromolecules nanoparticles Nanostructure Polyethylene glycol Polymerization Polystyrene Polystyrene resins RAFT polymerization Self-assembly Styrene Topology Vesicles water |
| title | The Effect of Hydrophile Topology in RAFT-Mediated Polymerization-Induced Self-Assembly |
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