Novel insights into FAS defects underlying autoimmune lymphoproliferative syndrome revealed by studies in consanguineous patients

Autoimmune lymphoproliferative syndrome (ALPS) is a primary immunodeficiency disease due to impaired Fas‐Fas ligand apoptotic pathway. It is characterized by chronic nonmalignant, noninfectious lymphadenopathy and/or splenomegaly associated with autoimmune manifestations primarily directed against b...

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Veröffentlicht in:	Journal of leukocyte biology 2018-03, Vol.103 (3), p.501-508
Hauptverfasser:	Ben‐Mustapha, Imen, Agrebi, Nourhen, Barbouche, Mohamed‐Ridha
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune Lymphoproliferative Syndrome - genetics Autoimmune Lymphoproliferative Syndrome - immunology Consanguinity fas Receptor - deficiency fas Receptor - genetics fas Receptor - immunology Human health and pathology Humans Life Sciences Mutation Severity of Illness Index
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