Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis

Purpose To improve microscopic evaluation of immune cells relevant in breast cancer oncoimmunology, we aim at distinguishing normal infiltration patterns from lymphocytic lobulitis by advanced image analysis. We consider potential immune cell variations due to the menstrual cycle and oral contracept...

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Veröffentlicht in:	Breast cancer research and treatment 2017-07, Vol.164 (2), p.305-315
Hauptverfasser:	Schaadt, Nadine S., Alfonso, Juan Carlos López, Schönmeyer, Ralf, Grote, Anne, Forestier, Germain, Wemmert, Cédric, Krönke, Nicole, Stoeckelhuber, Mechthild, Kreipe, Hans H., Hatzikirou, Haralampos, Feuerhake, Friedrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Artificial Intelligence Biopsy Birth control Breast cancer Breast reconstruction Breasts Cancer research CD163 antigen CD4 antigen CD4-Positive T-Lymphocytes - metabolism CD8 antigen CD8-Positive T-Lymphocytes - metabolism Cell proliferation Cell recognition Computer Science Contraceptives, Oral Epithelial cells Epithelium Female Geospatial data Humans Image processing Inflammation Lymphocytes - immunology Lymphocytes T Macrophages Macrophages - immunology Mammaplasty Mammary gland Mammary Glands, Human - anatomy & histology Mammary Glands, Human - immunology Mammary Glands, Human - surgery Medicine Medicine & Public Health Menstrual Cycle Menstruation Oncology Oral contraceptives Preclinical Study Receptors, Cell Surface - metabolism Spatial distribution T cell receptors T cells Workflow software
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