One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles
Ultrasmall silica nanoparticles (NPs), having hydrodynamic diameters under 10 nm are promising inorganic platforms for imaging and therapeutic applications in medicine. Herein is described a new way for synthesizing such kind of NPs in a one-pot scalable protocol. These NPs bear DOTA (1,4,7,10-tetra...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2018-08, Vol.6 (29), p.4821-4834 |
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| creator | Tran, Vu-Long Thakare, Vivek Rossetti, Fabien Baudouin, Anne Ramniceanu, Grégory Doan, Bich-Thuy Mignet, Nathalie Comby-Zerbino, Clothilde Antoine, Rodolphe Dugourd, Philippe Boschetti, Frédéric Denat, Franck Louis, Cédric Roux, Stéphane Doussineau, Tristan Tillement, Olivier Lux, François |
| description | Ultrasmall silica nanoparticles (NPs), having hydrodynamic diameters under 10 nm are promising inorganic platforms for imaging and therapeutic applications in medicine. Herein is described a new way for synthesizing such kind of NPs in a one-pot scalable protocol. These NPs bear DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) ligands on their surface that can chelate different metals suitable for a wide variety of biomedical applications. By varying the ratio of the precursors, the hydrodynamic diameters of the particles can be controlled over the range of 3 to 15 nm. The resulting NPs have been characterized extensively by complementary techniques like dynamic light scattering (DLS), high performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR), mass spectrometry (MS), phosphorescence titration, photophysical measurements, relaxometry and elemental analysis to elucidate their structures. Chelation of gadolinium (Gd) allowed its use as an effective intravenous contrast agent in MRI and was illustrated in mice bearing colorectal CT26 tumors. The new particle appears to sufficiently accumulate in the tumors and efficiently clear out of animal bodies through kidneys. This new synthesis is an original, time/material-saving and very flexible process that can be applied for creating versatile ultrasmall multifunctional nanomedicines. |
| doi_str_mv | 10.1039/c8tb00195b |
| format | Article |
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Herein is described a new way for synthesizing such kind of NPs in a one-pot scalable protocol. These NPs bear DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) ligands on their surface that can chelate different metals suitable for a wide variety of biomedical applications. By varying the ratio of the precursors, the hydrodynamic diameters of the particles can be controlled over the range of 3 to 15 nm. The resulting NPs have been characterized extensively by complementary techniques like dynamic light scattering (DLS), high performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR), mass spectrometry (MS), phosphorescence titration, photophysical measurements, relaxometry and elemental analysis to elucidate their structures. Chelation of gadolinium (Gd) allowed its use as an effective intravenous contrast agent in MRI and was illustrated in mice bearing colorectal CT26 tumors. The new particle appears to sufficiently accumulate in the tumors and efficiently clear out of animal bodies through kidneys. This new synthesis is an original, time/material-saving and very flexible process that can be applied for creating versatile ultrasmall multifunctional nanomedicines.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c8tb00195b</identifier><identifier>PMID: 32254309</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Analytical chemistry ; Biomedical materials ; Chelates ; Chelation ; Chemical Sciences ; Contrast agents ; Gadolinium ; High performance liquid chromatography ; Inorganic chemistry ; Intravenous administration ; Kidneys ; Light scattering ; Liquid chromatography ; Magnetic resonance imaging ; Mass spectrometry ; Mass spectroscopy ; Metals ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Phosphorescence ; Photon correlation spectroscopy ; Resonance scattering ; Silica ; Silicon dioxide ; Synthesis ; Therapeutic applications ; Titration ; Tumors</subject><ispartof>Journal of materials chemistry. 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B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Ultrasmall silica nanoparticles (NPs), having hydrodynamic diameters under 10 nm are promising inorganic platforms for imaging and therapeutic applications in medicine. Herein is described a new way for synthesizing such kind of NPs in a one-pot scalable protocol. These NPs bear DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) ligands on their surface that can chelate different metals suitable for a wide variety of biomedical applications. By varying the ratio of the precursors, the hydrodynamic diameters of the particles can be controlled over the range of 3 to 15 nm. The resulting NPs have been characterized extensively by complementary techniques like dynamic light scattering (DLS), high performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR), mass spectrometry (MS), phosphorescence titration, photophysical measurements, relaxometry and elemental analysis to elucidate their structures. Chelation of gadolinium (Gd) allowed its use as an effective intravenous contrast agent in MRI and was illustrated in mice bearing colorectal CT26 tumors. The new particle appears to sufficiently accumulate in the tumors and efficiently clear out of animal bodies through kidneys. This new synthesis is an original, time/material-saving and very flexible process that can be applied for creating versatile ultrasmall multifunctional nanomedicines.</description><subject>Analytical chemistry</subject><subject>Biomedical materials</subject><subject>Chelates</subject><subject>Chelation</subject><subject>Chemical Sciences</subject><subject>Contrast agents</subject><subject>Gadolinium</subject><subject>High performance liquid chromatography</subject><subject>Inorganic chemistry</subject><subject>Intravenous administration</subject><subject>Kidneys</subject><subject>Light scattering</subject><subject>Liquid chromatography</subject><subject>Magnetic resonance imaging</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metals</subject><subject>Nanoparticles</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phosphorescence</subject><subject>Photon correlation spectroscopy</subject><subject>Resonance scattering</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Synthesis</subject><subject>Therapeutic applications</subject><subject>Titration</subject><subject>Tumors</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpd0c9PwyAUB3BiNM7MXfwDTBMvalKFUigct8VfyRIP7uCtoUAzFloqUJP996LTHeTyeC-fvEC-AFwgeIcg5veSxQZCxElzBM4KSGBeEcSOD3f4PgGzELYwHYYow-UpmOCiICWG_Ay8vfY6H1zMlPFaxizs-rjRwYSsdT7rRhtNO_YyGtcLm6XWi9AJa7PNrvFGZcFYI0XWi94NwkcjrQ7n4KQVNujZb52C9ePDevmcr16fXpbzVS5xyWPeUt5oIbmgRFcKk1IwTnWFKGUtp0XFoVKk5FRKhVOnsCK4ZRIrXnLYNngKbvZrN8LWgzed8LvaCVM_z1f19wwiRlEFy0-U7PXeDt59jDrEujNBamtFr90Y6gKzqiC8LGCiV__o1o0-_T4pWJGKIlaQpG73SnoXgtft4QUI1t_B1Eu2XvwEs0j48nfl2HRaHehfDPgLKHiHug</recordid><startdate>20180807</startdate><enddate>20180807</enddate><creator>Tran, Vu-Long</creator><creator>Thakare, Vivek</creator><creator>Rossetti, Fabien</creator><creator>Baudouin, Anne</creator><creator>Ramniceanu, Grégory</creator><creator>Doan, Bich-Thuy</creator><creator>Mignet, Nathalie</creator><creator>Comby-Zerbino, Clothilde</creator><creator>Antoine, Rodolphe</creator><creator>Dugourd, Philippe</creator><creator>Boschetti, Frédéric</creator><creator>Denat, Franck</creator><creator>Louis, Cédric</creator><creator>Roux, Stéphane</creator><creator>Doussineau, Tristan</creator><creator>Tillement, Olivier</creator><creator>Lux, François</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-5682-8550</orcidid><orcidid>https://orcid.org/0000-0001-8178-3147</orcidid><orcidid>https://orcid.org/0000-0003-1568-0240</orcidid><orcidid>https://orcid.org/0000-0001-5371-8508</orcidid><orcidid>https://orcid.org/0000-0002-9652-4006</orcidid><orcidid>https://orcid.org/0000-0003-0998-6999</orcidid><orcidid>https://orcid.org/0000-0003-4395-1140</orcidid><orcidid>https://orcid.org/0000-0002-3323-2997</orcidid><orcidid>https://orcid.org/0000-0001-7166-6537</orcidid></search><sort><creationdate>20180807</creationdate><title>One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles</title><author>Tran, Vu-Long ; 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B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran, Vu-Long</au><au>Thakare, Vivek</au><au>Rossetti, Fabien</au><au>Baudouin, Anne</au><au>Ramniceanu, Grégory</au><au>Doan, Bich-Thuy</au><au>Mignet, Nathalie</au><au>Comby-Zerbino, Clothilde</au><au>Antoine, Rodolphe</au><au>Dugourd, Philippe</au><au>Boschetti, Frédéric</au><au>Denat, Franck</au><au>Louis, Cédric</au><au>Roux, Stéphane</au><au>Doussineau, Tristan</au><au>Tillement, Olivier</au><au>Lux, François</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles</atitle><jtitle>Journal of materials chemistry. 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The resulting NPs have been characterized extensively by complementary techniques like dynamic light scattering (DLS), high performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR), mass spectrometry (MS), phosphorescence titration, photophysical measurements, relaxometry and elemental analysis to elucidate their structures. Chelation of gadolinium (Gd) allowed its use as an effective intravenous contrast agent in MRI and was illustrated in mice bearing colorectal CT26 tumors. The new particle appears to sufficiently accumulate in the tumors and efficiently clear out of animal bodies through kidneys. This new synthesis is an original, time/material-saving and very flexible process that can be applied for creating versatile ultrasmall multifunctional nanomedicines.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32254309</pmid><doi>10.1039/c8tb00195b</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5682-8550</orcidid><orcidid>https://orcid.org/0000-0001-8178-3147</orcidid><orcidid>https://orcid.org/0000-0003-1568-0240</orcidid><orcidid>https://orcid.org/0000-0001-5371-8508</orcidid><orcidid>https://orcid.org/0000-0002-9652-4006</orcidid><orcidid>https://orcid.org/0000-0003-0998-6999</orcidid><orcidid>https://orcid.org/0000-0003-4395-1140</orcidid><orcidid>https://orcid.org/0000-0002-3323-2997</orcidid><orcidid>https://orcid.org/0000-0001-7166-6537</orcidid></addata></record> |
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| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2018-08, Vol.6 (29), p.4821-4834 |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Analytical chemistry Biomedical materials Chelates Chelation Chemical Sciences Contrast agents Gadolinium High performance liquid chromatography Inorganic chemistry Intravenous administration Kidneys Light scattering Liquid chromatography Magnetic resonance imaging Mass spectrometry Mass spectroscopy Metals Nanoparticles NMR Nuclear magnetic resonance Phosphorescence Photon correlation spectroscopy Resonance scattering Silica Silicon dioxide Synthesis Therapeutic applications Titration Tumors |
| title | One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles |
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