In Hemodialysis Patients, Intradialytic Resistance Exercise Improves Osteoblast Function: A Pilot Study
Objective Abnormalities in mineral and bone metabolism are frequent in chronic kidney disease patients. Physical exercise can improve many indicators of physical functioning, and recent studies showed beneficial effects on bone mineral density in the general population. The aim of this study was to...
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| Veröffentlicht in: | Journal of renal nutrition 2016-09, Vol.26 (5), p.341-345 |
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| creator | Marinho, Sandra Mara S. de A., MD, PhD Mafra, Denise, MD, PhD Pelletier, Solenne, MD, PhD Hage, Valerie, MD Teuma, Cécile Laville, Maurice, MD Carraro Eduardo, José Carlos, MD, PhD Fouque, Denis, MD, PhD |
| description | Objective Abnormalities in mineral and bone metabolism are frequent in chronic kidney disease patients. Physical exercise can improve many indicators of physical functioning, and recent studies showed beneficial effects on bone mineral density in the general population. The aim of this study was to evaluate the effects of resistance exercise training on bone markers and body composition in hemodialysis (HD) patients. Design This was a randomized controlled trial. Subjects The study included 13 HD patients (46.2% men). Intervention Patients were divided into a control group and an exercise group, which performed 8 weeks of intradialytic resistance exercise. Serum sclerostin, bone alkaline phosphatase (BAP), insulin, leptin, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and body composition were measured before and after the exercise period. Results In the exercise group, BAP levels increased from 11.4 ± 6.5 to 14.6 ± 6.4 U/L ( P |
| doi_str_mv | 10.1053/j.jrn.2016.03.002 |
| format | Article |
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Physical exercise can improve many indicators of physical functioning, and recent studies showed beneficial effects on bone mineral density in the general population. The aim of this study was to evaluate the effects of resistance exercise training on bone markers and body composition in hemodialysis (HD) patients. Design This was a randomized controlled trial. Subjects The study included 13 HD patients (46.2% men). Intervention Patients were divided into a control group and an exercise group, which performed 8 weeks of intradialytic resistance exercise. Serum sclerostin, bone alkaline phosphatase (BAP), insulin, leptin, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and body composition were measured before and after the exercise period. Results In the exercise group, BAP levels increased from 11.4 ± 6.5 to 14.6 ± 6.4 U/L ( P < .05) and serum 1,25-dihydroxyvitamin D levels from 46.0 ± 23.5 to 87.2 ± 31.8 ng/mL ( P < .05). After exercise, serum BAP levels were inversely correlated with serum sclerostin (r = −0.96, P < .05). There was no change in body composition in either group. Conclusion Resistance exercise training appears to be an interesting approach for stimulating BAP production in HD patients and may prevent bone loss and stimulate bone formation.</description><identifier>ISSN: 1051-2276</identifier><identifier>EISSN: 1532-8503</identifier><identifier>DOI: 10.1053/j.jrn.2016.03.002</identifier><identifier>PMID: 27113628</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Exercise ; Exercise Therapy ; Health Status ; Humans ; Life Sciences ; Male ; Nephrology ; Osteoblasts - physiology ; Osteogenesis ; Pilot Projects ; Renal Dialysis ; Vitamin D - analogs & derivatives</subject><ispartof>Journal of renal nutrition, 2016-09, Vol.26 (5), p.341-345</ispartof><rights>National Kidney Foundation, Inc.</rights><rights>2016 National Kidney Foundation, Inc.</rights><rights>Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-bfa5a28f912a907e0eab7a817c3637eb998b75f6dc25a8db5ce56d0c3c56a2eb3</citedby><cites>FETCH-LOGICAL-c442t-bfa5a28f912a907e0eab7a817c3637eb998b75f6dc25a8db5ce56d0c3c56a2eb3</cites><orcidid>0000-0002-9707-7199</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/j.jrn.2016.03.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27113628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01850287$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Marinho, Sandra Mara S. de A., MD, PhD</creatorcontrib><creatorcontrib>Mafra, Denise, MD, PhD</creatorcontrib><creatorcontrib>Pelletier, Solenne, MD, PhD</creatorcontrib><creatorcontrib>Hage, Valerie, MD</creatorcontrib><creatorcontrib>Teuma, Cécile</creatorcontrib><creatorcontrib>Laville, Maurice, MD</creatorcontrib><creatorcontrib>Carraro Eduardo, José Carlos, MD, PhD</creatorcontrib><creatorcontrib>Fouque, Denis, MD, PhD</creatorcontrib><title>In Hemodialysis Patients, Intradialytic Resistance Exercise Improves Osteoblast Function: A Pilot Study</title><title>Journal of renal nutrition</title><addtitle>J Ren Nutr</addtitle><description>Objective Abnormalities in mineral and bone metabolism are frequent in chronic kidney disease patients. Physical exercise can improve many indicators of physical functioning, and recent studies showed beneficial effects on bone mineral density in the general population. The aim of this study was to evaluate the effects of resistance exercise training on bone markers and body composition in hemodialysis (HD) patients. Design This was a randomized controlled trial. Subjects The study included 13 HD patients (46.2% men). Intervention Patients were divided into a control group and an exercise group, which performed 8 weeks of intradialytic resistance exercise. Serum sclerostin, bone alkaline phosphatase (BAP), insulin, leptin, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and body composition were measured before and after the exercise period. Results In the exercise group, BAP levels increased from 11.4 ± 6.5 to 14.6 ± 6.4 U/L ( P < .05) and serum 1,25-dihydroxyvitamin D levels from 46.0 ± 23.5 to 87.2 ± 31.8 ng/mL ( P < .05). After exercise, serum BAP levels were inversely correlated with serum sclerostin (r = −0.96, P < .05). There was no change in body composition in either group. Conclusion Resistance exercise training appears to be an interesting approach for stimulating BAP production in HD patients and may prevent bone loss and stimulate bone formation.</description><subject>Exercise</subject><subject>Exercise Therapy</subject><subject>Health Status</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Nephrology</subject><subject>Osteoblasts - physiology</subject><subject>Osteogenesis</subject><subject>Pilot Projects</subject><subject>Renal Dialysis</subject><subject>Vitamin D - analogs & derivatives</subject><issn>1051-2276</issn><issn>1532-8503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkFv1DAQhSMEoqXwA7ggH0EiYWzXSRYkpFXVsiut1IrC2XKcCTg4drGdFfvvcdjSAwcu9mj8zZP83hTFSwoVBcHfjdUYXMWA1hXwCoA9Kk6p4KxsBfDHuQZBS8aa-qR4FuMIQKlo2dPihDWU8pq1p8W3rSMbnHxvlD1EE8mNSgZdim_J1qWg_vST0eQz5teknEZy-QuDNhHJdroLfo-RXMeEvrMqJnI1O52Md-_JmtwY6xO5TXN_eF48GZSN-OL-Piu-Xl1-udiUu-tP24v1rtTn5yyV3aCEYu2wokytoEFA1TWqpY3mNW-wW63arhFD3WsmVNt3QqOoe9Bci1ox7PhZ8eao-11ZeRfMpMJBemXkZr2TSw9oNoe1zZ5m9vWRzb_4OWNMcjJRo7XKoZ-jpO1iUj7rjNIjqoOPMeDwoE1BLlnIUeYs5JKFBC5zFnnm1b383E3YP0z8NT8DH44AZkP2BoOMOnuvsTcBdZK9N_-V__jPtLbGGa3sDzxgHP0cXHZaUhmZBHm7LMOyC7QGyCXw3_dgrww</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Marinho, Sandra Mara S. de A., MD, PhD</creator><creator>Mafra, Denise, MD, PhD</creator><creator>Pelletier, Solenne, MD, PhD</creator><creator>Hage, Valerie, MD</creator><creator>Teuma, Cécile</creator><creator>Laville, Maurice, MD</creator><creator>Carraro Eduardo, José Carlos, MD, PhD</creator><creator>Fouque, Denis, MD, PhD</creator><general>Elsevier Inc</general><general>WB Saunders</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9707-7199</orcidid></search><sort><creationdate>20160901</creationdate><title>In Hemodialysis Patients, Intradialytic Resistance Exercise Improves Osteoblast Function: A Pilot Study</title><author>Marinho, Sandra Mara S. de A., MD, PhD ; Mafra, Denise, MD, PhD ; Pelletier, Solenne, MD, PhD ; Hage, Valerie, MD ; Teuma, Cécile ; Laville, Maurice, MD ; Carraro Eduardo, José Carlos, MD, PhD ; Fouque, Denis, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-bfa5a28f912a907e0eab7a817c3637eb998b75f6dc25a8db5ce56d0c3c56a2eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Exercise</topic><topic>Exercise Therapy</topic><topic>Health Status</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Nephrology</topic><topic>Osteoblasts - physiology</topic><topic>Osteogenesis</topic><topic>Pilot Projects</topic><topic>Renal Dialysis</topic><topic>Vitamin D - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marinho, Sandra Mara S. de A., MD, PhD</creatorcontrib><creatorcontrib>Mafra, Denise, MD, PhD</creatorcontrib><creatorcontrib>Pelletier, Solenne, MD, PhD</creatorcontrib><creatorcontrib>Hage, Valerie, MD</creatorcontrib><creatorcontrib>Teuma, Cécile</creatorcontrib><creatorcontrib>Laville, Maurice, MD</creatorcontrib><creatorcontrib>Carraro Eduardo, José Carlos, MD, PhD</creatorcontrib><creatorcontrib>Fouque, Denis, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of renal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marinho, Sandra Mara S. de A., MD, PhD</au><au>Mafra, Denise, MD, PhD</au><au>Pelletier, Solenne, MD, PhD</au><au>Hage, Valerie, MD</au><au>Teuma, Cécile</au><au>Laville, Maurice, MD</au><au>Carraro Eduardo, José Carlos, MD, PhD</au><au>Fouque, Denis, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Hemodialysis Patients, Intradialytic Resistance Exercise Improves Osteoblast Function: A Pilot Study</atitle><jtitle>Journal of renal nutrition</jtitle><addtitle>J Ren Nutr</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>26</volume><issue>5</issue><spage>341</spage><epage>345</epage><pages>341-345</pages><issn>1051-2276</issn><eissn>1532-8503</eissn><abstract>Objective Abnormalities in mineral and bone metabolism are frequent in chronic kidney disease patients. Physical exercise can improve many indicators of physical functioning, and recent studies showed beneficial effects on bone mineral density in the general population. The aim of this study was to evaluate the effects of resistance exercise training on bone markers and body composition in hemodialysis (HD) patients. Design This was a randomized controlled trial. Subjects The study included 13 HD patients (46.2% men). Intervention Patients were divided into a control group and an exercise group, which performed 8 weeks of intradialytic resistance exercise. Serum sclerostin, bone alkaline phosphatase (BAP), insulin, leptin, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and body composition were measured before and after the exercise period. Results In the exercise group, BAP levels increased from 11.4 ± 6.5 to 14.6 ± 6.4 U/L ( P < .05) and serum 1,25-dihydroxyvitamin D levels from 46.0 ± 23.5 to 87.2 ± 31.8 ng/mL ( P < .05). After exercise, serum BAP levels were inversely correlated with serum sclerostin (r = −0.96, P < .05). There was no change in body composition in either group. Conclusion Resistance exercise training appears to be an interesting approach for stimulating BAP production in HD patients and may prevent bone loss and stimulate bone formation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27113628</pmid><doi>10.1053/j.jrn.2016.03.002</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9707-7199</orcidid></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Exercise Exercise Therapy Health Status Humans Life Sciences Male Nephrology Osteoblasts - physiology Osteogenesis Pilot Projects Renal Dialysis Vitamin D - analogs & derivatives |
| title | In Hemodialysis Patients, Intradialytic Resistance Exercise Improves Osteoblast Function: A Pilot Study |
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