High efficiency cell-specific targeting of cytokine activity

Systemic toxicity currently prevents exploiting the huge potential of many cytokines for medical applications. Here we present a novel strategy to engineer immunocytokines with very high targeting efficacies. The method lies in the use of mutants of toxic cytokines that markedly reduce their recepto...

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Veröffentlicht in:	Nature communications 2014-01, Vol.5 (1), p.3016-3016, Article 3016
Hauptverfasser:	Garcin, Geneviève, Paul, Franciane, Staufenbiel, Markus, Bordat, Yann, Van der Heyden, José, Wilmes, Stephan, Cartron, Guillaume, Apparailly, Florence, De Koker, Stefaan, Piehler, Jacob, Tavernier, Jan, Uzé, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127 631/61/338 96/1 96/21 96/31 96/35 96/95 Animals Cytokines Cytokines - metabolism Drug Delivery Systems Humanities and Social Sciences Humans Interferon Type I - metabolism Interferon-alpha - metabolism Interleukin-15 - metabolism Interleukin-2 - metabolism Leptin - metabolism Life Sciences Mice multidisciplinary Protein Binding Proteins Receptor, Interferon alpha-beta - metabolism Receptors, Cytokine - metabolism Receptors, Leptin Receptors, Tumor Necrosis Factor, Type I - metabolism Science Science (multidisciplinary) Single-Domain Antibodies - metabolism Toxicity
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