PBPK modeling of irbesartan: incorporation of hepatic uptake

Physiological based pharmacokinetic (PBPK) modeling is now commonly used in drug development to integrate human or animal physiological data in order to predict pharmacokinetic profiles. The aim of this work was to construct and refine a PBPK model of irbesartan taking into account its active uptake...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2015-11, Vol.36 (8), p.491-506
Hauptverfasser:	Chapy, Helene, Klieber, Sylvie, Brun, Priscilla, Gerbal-Chaloin, Sabine, Boulenc, Xavier, Nicolas, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiotensin II Type 1 Receptor Blockers - pharmacokinetics Biphenyl Compounds - pharmacokinetics Blotting, Western Cells, Cultured Chromatography, Liquid Computer Simulation Glycosylation HEK293 Cells Hepatocytes - metabolism Humans irbesartan Kinetics Life Sciences Liver - metabolism Models, Biological OATP Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Organic Anion Transporters, Sodium-Independent - genetics Organic Anion Transporters, Sodium-Independent - metabolism PBPK Primary Cell Culture scaling factor Solute Carrier Organic Anion Transporter Family Member 1b1 Solute Carrier Organic Anion Transporter Family Member 1B3 Tandem Mass Spectrometry Tetrazoles - pharmacokinetics Transfection transporter
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