p-Cresyl glucuronide is a major metabolite of p-cresol in mouse: in contrast to p-cresyl sulphate, p-cresyl glucuronide fails to promote insulin resistance

The role of uraemic toxins in insulin resistance associated with chronic kidney disease (CKD) is gaining interest. p-Cresol has been defined as the intestinally generated precursor of the prototype protein-bound uraemic toxins p-cresyl sulphate (p-CS) as the main metabolite and, at a markedly lower...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2017-12, Vol.32 (12), p.2000-2009
Hauptverfasser:	Koppe, Laetitia, Alix, Pascaline M, Croze, Marine L, Chambert, Stéphane, Vanholder, Raymond, Glorieux, Griet, Fouque, Denis, Soulage, Christophe O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cresols - blood Cresols - pharmacology Glucuronides - blood Glucuronides - pharmacology Insulin - metabolism Insulin Resistance Life Sciences Mice Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - physiopathology Signal Transduction - drug effects Sulfuric Acid Esters - blood Sulfuric Acid Esters - pharmacology
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