Development and validation of an UHPLC-HRMS protocol for the analysis of flavan-3-ol metabolites and catabolites in urine, plasma and feces of rats fed a red wine proanthocyanidin extract

•Validation of a new LC-HRMS method to determine in vivo metabolites/catabolites.•34 metabolites/catabolites from a red wine proanthocyanidin extract were quantified.•Enable quantification of metabolites/catabolites in rat plasma, urine and feces.•Full validation according to the EURACHEM guidelines...

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Veröffentlicht in:	Food chemistry 2018-06, Vol.252, p.49-60
Hauptverfasser:	Pereira-Caro, Gema, Ordóñez, José Luis, Ludwig, Iziar, Gaillet, Sylvie, Mena, Pedro, Del Rio, Daniele, Rouanet, Jean-Max, Bindon, Keren A., Moreno-Rojas, José Manuel, Crozier, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioavailability Biological Availability Chromatography, High Pressure Liquid - methods Feces - chemistry Flavonoids - blood Flavonoids - metabolism Flavonoids - pharmacokinetics Flavonoids - urine Life Sciences Limit of Detection Male Mass Spectrometry - methods Method validation Microbial-derived catabolites Phenylvalerolactones Proanthocyanidins - pharmacology Rats UHPLC-HR-MS Wine - analysis Wine proanthocyanidins
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