Alpha-internexin expression in gliomas: relationship with histological type and 1p, 19q, 10p and 10q status

BackgroundThe alpha-internexin (INA) gene encodes an intermediate filament involved in neurogenesis and maps in 10q24.33. A strong INA protein expression has been reported in oligodendroglial tumours and was associated with 1p19q deletion. To assess the relevance of INA immunohistochemistry in gliom...

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Veröffentlicht in:	Journal of clinical pathology 2011-09, Vol.64 (9), p.793-801
Hauptverfasser:	Durand, Karine, Guillaudeau, Angélique, Pommepuy, Isabelle, Mesturoux, Laura, Chaunavel, Alain, Gadeaud, Emilie, Porcheron, Marion, Moreau, Jean-Jacques, Labrousse, François
Format:	Artikel
Sprache:	eng
Schlagworte:	10p10q loss 1p19q loss Adult Aged Alpha-internexin Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain Neoplasms - diagnosis Brain Neoplasms - genetics Brain Neoplasms - metabolism brain tumours Cellular Biology central nerve system Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 19 DNA, Neoplasm - analysis Female Gene Expression Regulation, Neoplastic genetics glioma Glioma - diagnosis Glioma - genetics Glioma - metabolism Humans Immunohistochemistry Intermediate Filament Proteins - genetics Investigative techniques, diagnostic techniques (general aspects) Life Sciences Loss of Heterozygosity Male Medical sciences Middle Aged molecular markers molecular oncology Neurology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques PCR Prognosis Retrospective Studies Tumors of the nervous system. Phacomatoses
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