New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study
Atrial fibrillation (AFib) is associated with adverse outcome in critical illness, but whether this effect is independent from other risk factors remains uncertain. New-onset AFib during critical illness may be independently associated with increased in-hospital and long-term risk of death. FROG-ICU...
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| Veröffentlicht in: | International journal of cardiology 2018-09, Vol.266, p.95-99 |
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| creator | Arrigo, Mattia Ishihara, Shiro Feliot, Elodie Rudiger, Alain Deye, Nicolas Cariou, Alain Guidet, Bertrand Jaber, Samir Leone, Marc Resche-Rigon, Matthieu Vieillard Baron, Antoine Legrand, Matthieu Gayat, Etienne Mebazaa, Alexandre |
| description | Atrial fibrillation (AFib) is associated with adverse outcome in critical illness, but whether this effect is independent from other risk factors remains uncertain. New-onset AFib during critical illness may be independently associated with increased in-hospital and long-term risk of death.
FROG-ICU was a prospective, observational, multi-centre cohort study designed to investigate the outcome of critically ill patients. Inclusion criteria were invasive mechanical ventilation and/or treatment with a positive inotropic agent for >24 h. Heart rhythm was assessed at inclusion and during ICU stay with digital ECG recordings. Among patients who had AFib during ICU stay, new-onset and recurrent AFib were diagnosed in patients without and with previous history of AFib, respectively. Primary endpoint was in-hospital mortality; secondary endpoint was 1-year mortality among ICU survivors.
The study included 1841 critically ill patients. During ICU stay, AFib occurred in 343 patients (19%). New-onset AFib (n = 212) had higher in-hospital mortality compared to no AFib (47 vs. 23%, P |
| doi_str_mv | 10.1016/j.ijcard.2018.03.051 |
| format | Article |
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FROG-ICU was a prospective, observational, multi-centre cohort study designed to investigate the outcome of critically ill patients. Inclusion criteria were invasive mechanical ventilation and/or treatment with a positive inotropic agent for >24 h. Heart rhythm was assessed at inclusion and during ICU stay with digital ECG recordings. Among patients who had AFib during ICU stay, new-onset and recurrent AFib were diagnosed in patients without and with previous history of AFib, respectively. Primary endpoint was in-hospital mortality; secondary endpoint was 1-year mortality among ICU survivors.
The study included 1841 critically ill patients. During ICU stay, AFib occurred in 343 patients (19%). New-onset AFib (n = 212) had higher in-hospital mortality compared to no AFib (47 vs. 23%, P < 0.001) or recurrent AFib (34%, P = 0.032). New-onset AFib showed increased risk of in-hospital death after multivariable adjustment compared to no AFib (OR 1.6, P = 0.003) or recurrent AFib (OR 1.8, P = 0.02). Among the 1464 ICU-survivors, new-onset AFib during ICU stay showed higher post-ICU risk of death compared to no AFib (HR 2.2, P < 0.001). After multivariable adjustment, new-onset AFib showed higher post-ICU risk of death compared to no AFib (HR 1.6, P = 0.03).
New-onset AFib is independently associated with in-hospital and post-ICU risk of death in critically ill patients.
•FROG-ICU was a multi-centre cohort study investigating outcome of critically ill patients.•During ICU stay, AFib occurred in 19% of patients•New-onset AFib, is independently associated with increased risk of in-hospital death.•New-onset AFib during critical illness, is independently associated with one-year outcome of ICU survivors.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2018.03.051</identifier><identifier>PMID: 29887481</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Atrial fibrillation ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - mortality ; Cohort Studies ; Critical illness ; Critical Illness - mortality ; Female ; France - epidemiology ; Hospital Mortality - trends ; Humans ; ICU ; Intensive Care Units - trends ; Life Sciences ; Male ; Mortality ; Outcome ; Prospective Studies ; Research Report - trends</subject><ispartof>International journal of cardiology, 2018-09, Vol.266, p.95-99</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-dda728ffbbcd0729dcfaa239fd67df4b8a1ebafc96d482ed024acc3839b129863</citedby><cites>FETCH-LOGICAL-c442t-dda728ffbbcd0729dcfaa239fd67df4b8a1ebafc96d482ed024acc3839b129863</cites><orcidid>0000-0001-9788-5316 ; 0000-0003-2220-5085 ; 0000-0003-4028-2869 ; 0000-0001-7943-7624 ; 0000-0001-9377-4301 ; 0000-0002-7257-8069 ; 0000-0001-8715-7753 ; 0000-0002-7643-6770</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2018.03.051$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29887481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.umontpellier.fr/hal-01815691$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Arrigo, Mattia</creatorcontrib><creatorcontrib>Ishihara, Shiro</creatorcontrib><creatorcontrib>Feliot, Elodie</creatorcontrib><creatorcontrib>Rudiger, Alain</creatorcontrib><creatorcontrib>Deye, Nicolas</creatorcontrib><creatorcontrib>Cariou, Alain</creatorcontrib><creatorcontrib>Guidet, Bertrand</creatorcontrib><creatorcontrib>Jaber, Samir</creatorcontrib><creatorcontrib>Leone, Marc</creatorcontrib><creatorcontrib>Resche-Rigon, Matthieu</creatorcontrib><creatorcontrib>Vieillard Baron, Antoine</creatorcontrib><creatorcontrib>Legrand, Matthieu</creatorcontrib><creatorcontrib>Gayat, Etienne</creatorcontrib><creatorcontrib>Mebazaa, Alexandre</creatorcontrib><title>New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Atrial fibrillation (AFib) is associated with adverse outcome in critical illness, but whether this effect is independent from other risk factors remains uncertain. New-onset AFib during critical illness may be independently associated with increased in-hospital and long-term risk of death.
FROG-ICU was a prospective, observational, multi-centre cohort study designed to investigate the outcome of critically ill patients. Inclusion criteria were invasive mechanical ventilation and/or treatment with a positive inotropic agent for >24 h. Heart rhythm was assessed at inclusion and during ICU stay with digital ECG recordings. Among patients who had AFib during ICU stay, new-onset and recurrent AFib were diagnosed in patients without and with previous history of AFib, respectively. Primary endpoint was in-hospital mortality; secondary endpoint was 1-year mortality among ICU survivors.
The study included 1841 critically ill patients. During ICU stay, AFib occurred in 343 patients (19%). New-onset AFib (n = 212) had higher in-hospital mortality compared to no AFib (47 vs. 23%, P < 0.001) or recurrent AFib (34%, P = 0.032). New-onset AFib showed increased risk of in-hospital death after multivariable adjustment compared to no AFib (OR 1.6, P = 0.003) or recurrent AFib (OR 1.8, P = 0.02). Among the 1464 ICU-survivors, new-onset AFib during ICU stay showed higher post-ICU risk of death compared to no AFib (HR 2.2, P < 0.001). After multivariable adjustment, new-onset AFib showed higher post-ICU risk of death compared to no AFib (HR 1.6, P = 0.03).
New-onset AFib is independently associated with in-hospital and post-ICU risk of death in critically ill patients.
•FROG-ICU was a multi-centre cohort study investigating outcome of critically ill patients.•During ICU stay, AFib occurred in 19% of patients•New-onset AFib, is independently associated with increased risk of in-hospital death.•New-onset AFib during critical illness, is independently associated with one-year outcome of ICU survivors.</description><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - mortality</subject><subject>Cohort Studies</subject><subject>Critical illness</subject><subject>Critical Illness - mortality</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Hospital Mortality - trends</subject><subject>Humans</subject><subject>ICU</subject><subject>Intensive Care Units - trends</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mortality</subject><subject>Outcome</subject><subject>Prospective Studies</subject><subject>Research Report - trends</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtr3DAUhUVoSaZp_kEoWjYLu5IsW1IXhWFoHjA0UJq1kPVgNNjWVNIkzKL_vTJOs-zqoqvvnss9B4BrjGqMcPdlX_u9VtHUBGFeo6ZGLT4DK8wZrTBr6TuwKhirWsKaC_AhpT1CiArBz8EFEbxgHK_Anx_2pQpTshmqHL0aoPN99MOgsg8T9BPU0Wev1TCcYGnDQ_mwU05QTQb6uaYUtF_wF593cAwxq8Hn01e4htEeyhO6GEaYdxbe_ny8qx42TzDlozl9BO-dGpK9eq2X4On2-6_NfbV9vHvYrLeVppTkyhjFCHeu77VBjAijnVKkEc50zDjac4Vtr5wWnaGcWIMIVVo3vBE9Lqd2zSW4WXR3apCH6EcVTzIoL-_XWzn3ioW47QR-xoX9vLCHGH4fbcpy9Enb4shkwzFJgtqGMIbFLEsXVMeQUrTuTRsjOYck93IJSc4hSdTIElIZ-_S64diP1rwN_UulAN8WwBZPnr2NMuliurbGR6uzNMH_f8Nfs6ymiQ</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Arrigo, Mattia</creator><creator>Ishihara, Shiro</creator><creator>Feliot, Elodie</creator><creator>Rudiger, Alain</creator><creator>Deye, Nicolas</creator><creator>Cariou, Alain</creator><creator>Guidet, Bertrand</creator><creator>Jaber, Samir</creator><creator>Leone, Marc</creator><creator>Resche-Rigon, Matthieu</creator><creator>Vieillard Baron, Antoine</creator><creator>Legrand, Matthieu</creator><creator>Gayat, Etienne</creator><creator>Mebazaa, Alexandre</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-9788-5316</orcidid><orcidid>https://orcid.org/0000-0003-2220-5085</orcidid><orcidid>https://orcid.org/0000-0003-4028-2869</orcidid><orcidid>https://orcid.org/0000-0001-7943-7624</orcidid><orcidid>https://orcid.org/0000-0001-9377-4301</orcidid><orcidid>https://orcid.org/0000-0002-7257-8069</orcidid><orcidid>https://orcid.org/0000-0001-8715-7753</orcidid><orcidid>https://orcid.org/0000-0002-7643-6770</orcidid></search><sort><creationdate>20180901</creationdate><title>New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study</title><author>Arrigo, Mattia ; 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New-onset AFib during critical illness may be independently associated with increased in-hospital and long-term risk of death.
FROG-ICU was a prospective, observational, multi-centre cohort study designed to investigate the outcome of critically ill patients. Inclusion criteria were invasive mechanical ventilation and/or treatment with a positive inotropic agent for >24 h. Heart rhythm was assessed at inclusion and during ICU stay with digital ECG recordings. Among patients who had AFib during ICU stay, new-onset and recurrent AFib were diagnosed in patients without and with previous history of AFib, respectively. Primary endpoint was in-hospital mortality; secondary endpoint was 1-year mortality among ICU survivors.
The study included 1841 critically ill patients. During ICU stay, AFib occurred in 343 patients (19%). New-onset AFib (n = 212) had higher in-hospital mortality compared to no AFib (47 vs. 23%, P < 0.001) or recurrent AFib (34%, P = 0.032). New-onset AFib showed increased risk of in-hospital death after multivariable adjustment compared to no AFib (OR 1.6, P = 0.003) or recurrent AFib (OR 1.8, P = 0.02). Among the 1464 ICU-survivors, new-onset AFib during ICU stay showed higher post-ICU risk of death compared to no AFib (HR 2.2, P < 0.001). After multivariable adjustment, new-onset AFib showed higher post-ICU risk of death compared to no AFib (HR 1.6, P = 0.03).
New-onset AFib is independently associated with in-hospital and post-ICU risk of death in critically ill patients.
•FROG-ICU was a multi-centre cohort study investigating outcome of critically ill patients.•During ICU stay, AFib occurred in 19% of patients•New-onset AFib, is independently associated with increased risk of in-hospital death.•New-onset AFib during critical illness, is independently associated with one-year outcome of ICU survivors.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29887481</pmid><doi>10.1016/j.ijcard.2018.03.051</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9788-5316</orcidid><orcidid>https://orcid.org/0000-0003-2220-5085</orcidid><orcidid>https://orcid.org/0000-0003-4028-2869</orcidid><orcidid>https://orcid.org/0000-0001-7943-7624</orcidid><orcidid>https://orcid.org/0000-0001-9377-4301</orcidid><orcidid>https://orcid.org/0000-0002-7257-8069</orcidid><orcidid>https://orcid.org/0000-0001-8715-7753</orcidid><orcidid>https://orcid.org/0000-0002-7643-6770</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of cardiology, 2018-09, Vol.266, p.95-99 |
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| subjects | Atrial fibrillation Atrial Fibrillation - diagnosis Atrial Fibrillation - mortality Cohort Studies Critical illness Critical Illness - mortality Female France - epidemiology Hospital Mortality - trends Humans ICU Intensive Care Units - trends Life Sciences Male Mortality Outcome Prospective Studies Research Report - trends |
| title | New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study |
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