Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington’s disease

Highlights • Reduced GABAergic protein expression in the external globus pallidus of R6/1 mice. • Early reduction of GABAergic neurotransmission and synapses in R6/1 mice. • Rest/activity rhythm is altered early in R6/1 mice revealing early sleep disturbances. • Early functional and behavioral alter...

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Veröffentlicht in:	Neuroscience 2016-08, Vol.329, p.363-379
Hauptverfasser:	Du, Zhuowei, Chazalon, Marine, Bestaven, Emma, Leste-Lasserre, Thierry, Baufreton, Jérôme, Cazalets, Jean-René, Cho, Yoon H, Garret, Maurice
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals basal ganglia Disease Models, Animal Disease Progression gamma-Aminobutyric Acid - metabolism Globus Pallidus - metabolism Globus Pallidus - pathology Humans Huntingtin Protein - genetics Huntingtin Protein - metabolism Huntington Disease - metabolism Huntington Disease - pathology inhibitory post-synaptic currents Inhibitory Postsynaptic Potentials - physiology Life Sciences locomotor activity Male Mice, Inbred C57BL Mice, Transgenic Miniature Postsynaptic Potentials - physiology Motor Activity - physiology Neurobiology Neurology Neurons and Cognition rest/activity fragmentation Sleep - physiology synapse Synapses - metabolism Tissue Culture Techniques Trinucleotide Repeat Expansion
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Zusammenfassung:	Highlights • Reduced GABAergic protein expression in the external globus pallidus of R6/1 mice. • Early reduction of GABAergic neurotransmission and synapses in R6/1 mice. • Rest/activity rhythm is altered early in R6/1 mice revealing early sleep disturbances. • Early functional and behavioral alterations in the R6/1 model of Huntington’s disease. • Our data reveal deficits at a young age when mice have been considered asymptomatic.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.05.027