Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice

Selenoprotein T (SelT) is a newly discovered thioredoxin-like protein, which is abundantly but transiently expressed in the neural lineage during brain ontogenesis. Because its physiological function in the brain remains unknown, we developed a conditional knockout mouse line (Nes-Cre/SelT fl/fl ) i...

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Veröffentlicht in:	Molecular neurobiology 2016-11, Vol.53 (9), p.5818-5832
Hauptverfasser:	Castex, Matthieu T., Arabo, Arnaud, Bénard, Magalie, Roy, Vincent, Le Joncour, Vadim, Prévost, Gaëtan, Bonnet, Jean-Jacques, Anouar, Youssef, Falluel-Morel, Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal behavior Animals Animals, Newborn Antioxidants Apoptosis Astrocytes - metabolism Behavior, Animal Biomedical and Life Sciences Biomedicine Brain - pathology Cell Biology Cell Proliferation Cell Survival Cognitive science Homeostasis Hyperactivity Hyperkinesis - metabolism Hyperkinesis - pathology Integrases - metabolism Mice, Inbred C57BL Mice, Knockout Nervous System - embryology Nervous System - metabolism Nervous System - pathology Nervous System Malformations - metabolism Nervous System Malformations - pathology Nestin - metabolism Neurobiology Neurogenesis Neurology Neurons - metabolism Neurons - pathology Neuroscience Neurosciences Organ Size Oxidation-Reduction Rats Reactive Oxygen Species - metabolism Rodents Selenoproteins - deficiency Selenoproteins - genetics
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