Affect lability predicts occurrence of suicidal ideation in bipolar patients: a two‐year prospective study
Objective The aim of our study was to investigate, in bipolar patients, whether affect lability was associated with suicidal ideation incidence during 2‐year follow‐up, and which subtype of affect lability was associated with suicidal ideation. Method A total of 319 euthymic or mildly depressed bipo...
Gespeichert in:
| Veröffentlicht in: | Acta psychiatrica Scandinavica 2017-05, Vol.135 (5), p.460-469 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 469 |
|---|---|
| container_issue | 5 |
| container_start_page | 460 |
| container_title | Acta psychiatrica Scandinavica |
| container_volume | 135 |
| creator | Ducasse, D. Jaussent, I. Guillaume, S. Azorin, J. M. Bellivier, F. Belzeaux, R. Bougerol, T. Etain, B. Gard, S. Henry, C. Kahn, J. P. Leboyer, M. Loftus, J. Passerieux, C. Olié, E. Courtet, P. Laouamri, H. Ngo‐Nguyen, N. Boudebesse, C. Raust, A. Leroux, M. Sportiche, S. Antoniol, B. Desage, A. Olie, E. Moliere, F. Viglianaise, N. Lescalier, L. Cohen, R. Wajsbrot‐Elgrabli, O. Polosan, M. Garcon, S. Hardy‐Bayle, M.C. Kayser, N. Aubin, V. Albertini, L. |
| description | Objective
The aim of our study was to investigate, in bipolar patients, whether affect lability was associated with suicidal ideation incidence during 2‐year follow‐up, and which subtype of affect lability was associated with suicidal ideation.
Method
A total of 319 euthymic or mildly depressed bipolar outpatients recruited in the French FondaMental Advanced Centres of Expertise for Bipolar Disorder were divided into two subgroups according to the occurrence of suicidal ideation during a 2‐year follow‐up. Affect lability was assessed by the French version of the Affect Lability Scale.
Results
Bipolar patients with high affect lability were more likely to report suicidal ideation during follow‐up, even after adjustment for age, study level, rapid cycling, current depression level, anxiety disorder, and lifetime history SA (OR = 2.47; 95% CI [1.15–5.30], P = 0.01). The risk of suicidal ideation increased with the level of affect lability. More specifically, the propensity to switch from neutral to elation affect, from anxious to depressive affect (or inversely), and from neutral to anger affect predicted suicidal ideation.
Conclusion
Reducing affective lability could become a new therapeutic target of suicidal prevention in bipolar disorder. |
| doi_str_mv | 10.1111/acps.12710 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01778330v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1874785537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4240-b6530abe535139f46482b9a8cc1dacf3d96e194ca1bfbe16674b2affb698576b3</originalsourceid><addsrcrecordid>eNqN0cGK1DAYB_Agiju7evEBJOBFha75mjRJvQ2D6woDCip4C0maYJZMW5N2l958BJ_RJzFj1z14EHMJ-fjxJ8kfoSdAzqGsV9qO-RxqAeQe2gAnpCKMiftoQwiBirfkywk6zfmqHBsg8iE6qWXNSU3ZBsWt985OOGoTYpgWPCbXBTtlPFg7p-R66_DgcZ6DDZ2OOHROT2HoceixCeMQdcJjmbh-yq-xxtPN8PP7j8Udx2nIYwkP1w7nae6WR-iB1zG7x7f7Gfp88ebT7rLav3_7brfdV5bVjFSGN5Ro4xraAG0940zWptXSWui09bRruYOWWQ3GGwecC2Zq7b3hrWwEN_QMvVhzv-qoxhQOOi1q0EFdbvfqOCMghKSUXEOxz1dbbvttdnlSh5Cti1H3bpizAtmCFBwE-Q8qmJBNQ0Whz_6iV8Oc-vLooiSjsqVNXdTLVdnyUzk5f3dZIOpYrTpWq35XW_DT28jZHFx3R_90WQCs4CZEt_wjSm13Hz6uob8AD1uu-g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1884389352</pqid></control><display><type>article</type><title>Affect lability predicts occurrence of suicidal ideation in bipolar patients: a two‐year prospective study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ducasse, D. ; Jaussent, I. ; Guillaume, S. ; Azorin, J. M. ; Bellivier, F. ; Belzeaux, R. ; Bougerol, T. ; Etain, B. ; Gard, S. ; Henry, C. ; Kahn, J. P. ; Leboyer, M. ; Loftus, J. ; Passerieux, C. ; Olié, E. ; Courtet, P. ; Laouamri, H. ; Ngo‐Nguyen, N. ; Boudebesse, C. ; Raust, A. ; Leroux, M. ; Sportiche, S. ; Antoniol, B. ; Desage, A. ; Olie, E. ; Moliere, F. ; Viglianaise, N. ; Lescalier, L. ; Cohen, R. ; Wajsbrot‐Elgrabli, O. ; Polosan, M. ; Garcon, S. ; Hardy‐Bayle, M.C. ; Kayser, N. ; Aubin, V. ; Albertini, L.</creator><creatorcontrib>Ducasse, D. ; Jaussent, I. ; Guillaume, S. ; Azorin, J. M. ; Bellivier, F. ; Belzeaux, R. ; Bougerol, T. ; Etain, B. ; Gard, S. ; Henry, C. ; Kahn, J. P. ; Leboyer, M. ; Loftus, J. ; Passerieux, C. ; Olié, E. ; Courtet, P. ; Laouamri, H. ; Ngo‐Nguyen, N. ; Boudebesse, C. ; Raust, A. ; Leroux, M. ; Sportiche, S. ; Antoniol, B. ; Desage, A. ; Olie, E. ; Moliere, F. ; Viglianaise, N. ; Lescalier, L. ; Cohen, R. ; Wajsbrot‐Elgrabli, O. ; Polosan, M. ; Garcon, S. ; Hardy‐Bayle, M.C. ; Kayser, N. ; Aubin, V. ; Albertini, L. ; FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators ; FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE‐BD) Collaborators</creatorcontrib><description>Objective
The aim of our study was to investigate, in bipolar patients, whether affect lability was associated with suicidal ideation incidence during 2‐year follow‐up, and which subtype of affect lability was associated with suicidal ideation.
Method
A total of 319 euthymic or mildly depressed bipolar outpatients recruited in the French FondaMental Advanced Centres of Expertise for Bipolar Disorder were divided into two subgroups according to the occurrence of suicidal ideation during a 2‐year follow‐up. Affect lability was assessed by the French version of the Affect Lability Scale.
Results
Bipolar patients with high affect lability were more likely to report suicidal ideation during follow‐up, even after adjustment for age, study level, rapid cycling, current depression level, anxiety disorder, and lifetime history SA (OR = 2.47; 95% CI [1.15–5.30], P = 0.01). The risk of suicidal ideation increased with the level of affect lability. More specifically, the propensity to switch from neutral to elation affect, from anxious to depressive affect (or inversely), and from neutral to anger affect predicted suicidal ideation.
Conclusion
Reducing affective lability could become a new therapeutic target of suicidal prevention in bipolar disorder.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/acps.12710</identifier><identifier>PMID: 28260234</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; affect lability ; Aged ; Bipolar disorder ; Bipolar Disorder - psychology ; Female ; Follow-Up Studies ; Human health and pathology ; Humans ; Incidence ; Life Sciences ; Male ; Middle Aged ; prospective follow‐up study ; Prospective Studies ; Psychiatric Status Rating Scales ; Psychiatrics and mental health ; Psychopathology ; Risk Factors ; Self destructive behavior ; Suicidal Ideation ; Suicide, Attempted - psychology ; Suicide, Attempted - statistics & numerical data ; Suicides & suicide attempts</subject><ispartof>Acta psychiatrica Scandinavica, 2017-05, Vol.135 (5), p.460-469</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2017 John Wiley & Sons A/S, Published by John Wiley & Sons Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4240-b6530abe535139f46482b9a8cc1dacf3d96e194ca1bfbe16674b2affb698576b3</citedby><cites>FETCH-LOGICAL-c4240-b6530abe535139f46482b9a8cc1dacf3d96e194ca1bfbe16674b2affb698576b3</cites><orcidid>0000-0002-5377-1488 ; 0000-0003-3874-5748 ; 0000-0002-3660-6640 ; 0000-0002-6769-9982 ; 0000-0002-6519-8586 ; 0000-0001-5473-3697 ; 0000-0003-4130-1590</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Facps.12710$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Facps.12710$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28260234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01778330$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ducasse, D.</creatorcontrib><creatorcontrib>Jaussent, I.</creatorcontrib><creatorcontrib>Guillaume, S.</creatorcontrib><creatorcontrib>Azorin, J. M.</creatorcontrib><creatorcontrib>Bellivier, F.</creatorcontrib><creatorcontrib>Belzeaux, R.</creatorcontrib><creatorcontrib>Bougerol, T.</creatorcontrib><creatorcontrib>Etain, B.</creatorcontrib><creatorcontrib>Gard, S.</creatorcontrib><creatorcontrib>Henry, C.</creatorcontrib><creatorcontrib>Kahn, J. P.</creatorcontrib><creatorcontrib>Leboyer, M.</creatorcontrib><creatorcontrib>Loftus, J.</creatorcontrib><creatorcontrib>Passerieux, C.</creatorcontrib><creatorcontrib>Olié, E.</creatorcontrib><creatorcontrib>Courtet, P.</creatorcontrib><creatorcontrib>Laouamri, H.</creatorcontrib><creatorcontrib>Ngo‐Nguyen, N.</creatorcontrib><creatorcontrib>Boudebesse, C.</creatorcontrib><creatorcontrib>Raust, A.</creatorcontrib><creatorcontrib>Leroux, M.</creatorcontrib><creatorcontrib>Sportiche, S.</creatorcontrib><creatorcontrib>Antoniol, B.</creatorcontrib><creatorcontrib>Desage, A.</creatorcontrib><creatorcontrib>Olie, E.</creatorcontrib><creatorcontrib>Moliere, F.</creatorcontrib><creatorcontrib>Viglianaise, N.</creatorcontrib><creatorcontrib>Lescalier, L.</creatorcontrib><creatorcontrib>Cohen, R.</creatorcontrib><creatorcontrib>Wajsbrot‐Elgrabli, O.</creatorcontrib><creatorcontrib>Polosan, M.</creatorcontrib><creatorcontrib>Garcon, S.</creatorcontrib><creatorcontrib>Hardy‐Bayle, M.C.</creatorcontrib><creatorcontrib>Kayser, N.</creatorcontrib><creatorcontrib>Aubin, V.</creatorcontrib><creatorcontrib>Albertini, L.</creatorcontrib><creatorcontrib>FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators</creatorcontrib><creatorcontrib>FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE‐BD) Collaborators</creatorcontrib><title>Affect lability predicts occurrence of suicidal ideation in bipolar patients: a two‐year prospective study</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective
The aim of our study was to investigate, in bipolar patients, whether affect lability was associated with suicidal ideation incidence during 2‐year follow‐up, and which subtype of affect lability was associated with suicidal ideation.
Method
A total of 319 euthymic or mildly depressed bipolar outpatients recruited in the French FondaMental Advanced Centres of Expertise for Bipolar Disorder were divided into two subgroups according to the occurrence of suicidal ideation during a 2‐year follow‐up. Affect lability was assessed by the French version of the Affect Lability Scale.
Results
Bipolar patients with high affect lability were more likely to report suicidal ideation during follow‐up, even after adjustment for age, study level, rapid cycling, current depression level, anxiety disorder, and lifetime history SA (OR = 2.47; 95% CI [1.15–5.30], P = 0.01). The risk of suicidal ideation increased with the level of affect lability. More specifically, the propensity to switch from neutral to elation affect, from anxious to depressive affect (or inversely), and from neutral to anger affect predicted suicidal ideation.
Conclusion
Reducing affective lability could become a new therapeutic target of suicidal prevention in bipolar disorder.</description><subject>Adult</subject><subject>affect lability</subject><subject>Aged</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - psychology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>prospective follow‐up study</subject><subject>Prospective Studies</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatrics and mental health</subject><subject>Psychopathology</subject><subject>Risk Factors</subject><subject>Self destructive behavior</subject><subject>Suicidal Ideation</subject><subject>Suicide, Attempted - psychology</subject><subject>Suicide, Attempted - statistics & numerical data</subject><subject>Suicides & suicide attempts</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0cGK1DAYB_Agiju7evEBJOBFha75mjRJvQ2D6woDCip4C0maYJZMW5N2l958BJ_RJzFj1z14EHMJ-fjxJ8kfoSdAzqGsV9qO-RxqAeQe2gAnpCKMiftoQwiBirfkywk6zfmqHBsg8iE6qWXNSU3ZBsWt985OOGoTYpgWPCbXBTtlPFg7p-R66_DgcZ6DDZ2OOHROT2HoceixCeMQdcJjmbh-yq-xxtPN8PP7j8Udx2nIYwkP1w7nae6WR-iB1zG7x7f7Gfp88ebT7rLav3_7brfdV5bVjFSGN5Ro4xraAG0940zWptXSWui09bRruYOWWQ3GGwecC2Zq7b3hrWwEN_QMvVhzv-qoxhQOOi1q0EFdbvfqOCMghKSUXEOxz1dbbvttdnlSh5Cti1H3bpizAtmCFBwE-Q8qmJBNQ0Whz_6iV8Oc-vLooiSjsqVNXdTLVdnyUzk5f3dZIOpYrTpWq35XW_DT28jZHFx3R_90WQCs4CZEt_wjSm13Hz6uob8AD1uu-g</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Ducasse, D.</creator><creator>Jaussent, I.</creator><creator>Guillaume, S.</creator><creator>Azorin, J. M.</creator><creator>Bellivier, F.</creator><creator>Belzeaux, R.</creator><creator>Bougerol, T.</creator><creator>Etain, B.</creator><creator>Gard, S.</creator><creator>Henry, C.</creator><creator>Kahn, J. P.</creator><creator>Leboyer, M.</creator><creator>Loftus, J.</creator><creator>Passerieux, C.</creator><creator>Olié, E.</creator><creator>Courtet, P.</creator><creator>Laouamri, H.</creator><creator>Ngo‐Nguyen, N.</creator><creator>Boudebesse, C.</creator><creator>Raust, A.</creator><creator>Leroux, M.</creator><creator>Sportiche, S.</creator><creator>Antoniol, B.</creator><creator>Desage, A.</creator><creator>Olie, E.</creator><creator>Moliere, F.</creator><creator>Viglianaise, N.</creator><creator>Lescalier, L.</creator><creator>Cohen, R.</creator><creator>Wajsbrot‐Elgrabli, O.</creator><creator>Polosan, M.</creator><creator>Garcon, S.</creator><creator>Hardy‐Bayle, M.C.</creator><creator>Kayser, N.</creator><creator>Aubin, V.</creator><creator>Albertini, L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5377-1488</orcidid><orcidid>https://orcid.org/0000-0003-3874-5748</orcidid><orcidid>https://orcid.org/0000-0002-3660-6640</orcidid><orcidid>https://orcid.org/0000-0002-6769-9982</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0001-5473-3697</orcidid><orcidid>https://orcid.org/0000-0003-4130-1590</orcidid></search><sort><creationdate>201705</creationdate><title>Affect lability predicts occurrence of suicidal ideation in bipolar patients: a two‐year prospective study</title><author>Ducasse, D. ; Jaussent, I. ; Guillaume, S. ; Azorin, J. M. ; Bellivier, F. ; Belzeaux, R. ; Bougerol, T. ; Etain, B. ; Gard, S. ; Henry, C. ; Kahn, J. P. ; Leboyer, M. ; Loftus, J. ; Passerieux, C. ; Olié, E. ; Courtet, P. ; Laouamri, H. ; Ngo‐Nguyen, N. ; Boudebesse, C. ; Raust, A. ; Leroux, M. ; Sportiche, S. ; Antoniol, B. ; Desage, A. ; Olie, E. ; Moliere, F. ; Viglianaise, N. ; Lescalier, L. ; Cohen, R. ; Wajsbrot‐Elgrabli, O. ; Polosan, M. ; Garcon, S. ; Hardy‐Bayle, M.C. ; Kayser, N. ; Aubin, V. ; Albertini, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4240-b6530abe535139f46482b9a8cc1dacf3d96e194ca1bfbe16674b2affb698576b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>affect lability</topic><topic>Aged</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - psychology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>prospective follow‐up study</topic><topic>Prospective Studies</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatrics and mental health</topic><topic>Psychopathology</topic><topic>Risk Factors</topic><topic>Self destructive behavior</topic><topic>Suicidal Ideation</topic><topic>Suicide, Attempted - psychology</topic><topic>Suicide, Attempted - statistics & numerical data</topic><topic>Suicides & suicide attempts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ducasse, D.</creatorcontrib><creatorcontrib>Jaussent, I.</creatorcontrib><creatorcontrib>Guillaume, S.</creatorcontrib><creatorcontrib>Azorin, J. M.</creatorcontrib><creatorcontrib>Bellivier, F.</creatorcontrib><creatorcontrib>Belzeaux, R.</creatorcontrib><creatorcontrib>Bougerol, T.</creatorcontrib><creatorcontrib>Etain, B.</creatorcontrib><creatorcontrib>Gard, S.</creatorcontrib><creatorcontrib>Henry, C.</creatorcontrib><creatorcontrib>Kahn, J. P.</creatorcontrib><creatorcontrib>Leboyer, M.</creatorcontrib><creatorcontrib>Loftus, J.</creatorcontrib><creatorcontrib>Passerieux, C.</creatorcontrib><creatorcontrib>Olié, E.</creatorcontrib><creatorcontrib>Courtet, P.</creatorcontrib><creatorcontrib>Laouamri, H.</creatorcontrib><creatorcontrib>Ngo‐Nguyen, N.</creatorcontrib><creatorcontrib>Boudebesse, C.</creatorcontrib><creatorcontrib>Raust, A.</creatorcontrib><creatorcontrib>Leroux, M.</creatorcontrib><creatorcontrib>Sportiche, S.</creatorcontrib><creatorcontrib>Antoniol, B.</creatorcontrib><creatorcontrib>Desage, A.</creatorcontrib><creatorcontrib>Olie, E.</creatorcontrib><creatorcontrib>Moliere, F.</creatorcontrib><creatorcontrib>Viglianaise, N.</creatorcontrib><creatorcontrib>Lescalier, L.</creatorcontrib><creatorcontrib>Cohen, R.</creatorcontrib><creatorcontrib>Wajsbrot‐Elgrabli, O.</creatorcontrib><creatorcontrib>Polosan, M.</creatorcontrib><creatorcontrib>Garcon, S.</creatorcontrib><creatorcontrib>Hardy‐Bayle, M.C.</creatorcontrib><creatorcontrib>Kayser, N.</creatorcontrib><creatorcontrib>Aubin, V.</creatorcontrib><creatorcontrib>Albertini, L.</creatorcontrib><creatorcontrib>FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators</creatorcontrib><creatorcontrib>FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE‐BD) Collaborators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ducasse, D.</au><au>Jaussent, I.</au><au>Guillaume, S.</au><au>Azorin, J. M.</au><au>Bellivier, F.</au><au>Belzeaux, R.</au><au>Bougerol, T.</au><au>Etain, B.</au><au>Gard, S.</au><au>Henry, C.</au><au>Kahn, J. P.</au><au>Leboyer, M.</au><au>Loftus, J.</au><au>Passerieux, C.</au><au>Olié, E.</au><au>Courtet, P.</au><au>Laouamri, H.</au><au>Ngo‐Nguyen, N.</au><au>Boudebesse, C.</au><au>Raust, A.</au><au>Leroux, M.</au><au>Sportiche, S.</au><au>Antoniol, B.</au><au>Desage, A.</au><au>Olie, E.</au><au>Moliere, F.</au><au>Viglianaise, N.</au><au>Lescalier, L.</au><au>Cohen, R.</au><au>Wajsbrot‐Elgrabli, O.</au><au>Polosan, M.</au><au>Garcon, S.</au><au>Hardy‐Bayle, M.C.</au><au>Kayser, N.</au><au>Aubin, V.</au><au>Albertini, L.</au><aucorp>FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators</aucorp><aucorp>FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE‐BD) Collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Affect lability predicts occurrence of suicidal ideation in bipolar patients: a two‐year prospective study</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2017-05</date><risdate>2017</risdate><volume>135</volume><issue>5</issue><spage>460</spage><epage>469</epage><pages>460-469</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><abstract>Objective
The aim of our study was to investigate, in bipolar patients, whether affect lability was associated with suicidal ideation incidence during 2‐year follow‐up, and which subtype of affect lability was associated with suicidal ideation.
Method
A total of 319 euthymic or mildly depressed bipolar outpatients recruited in the French FondaMental Advanced Centres of Expertise for Bipolar Disorder were divided into two subgroups according to the occurrence of suicidal ideation during a 2‐year follow‐up. Affect lability was assessed by the French version of the Affect Lability Scale.
Results
Bipolar patients with high affect lability were more likely to report suicidal ideation during follow‐up, even after adjustment for age, study level, rapid cycling, current depression level, anxiety disorder, and lifetime history SA (OR = 2.47; 95% CI [1.15–5.30], P = 0.01). The risk of suicidal ideation increased with the level of affect lability. More specifically, the propensity to switch from neutral to elation affect, from anxious to depressive affect (or inversely), and from neutral to anger affect predicted suicidal ideation.
Conclusion
Reducing affective lability could become a new therapeutic target of suicidal prevention in bipolar disorder.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>28260234</pmid><doi>10.1111/acps.12710</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5377-1488</orcidid><orcidid>https://orcid.org/0000-0003-3874-5748</orcidid><orcidid>https://orcid.org/0000-0002-3660-6640</orcidid><orcidid>https://orcid.org/0000-0002-6769-9982</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0001-5473-3697</orcidid><orcidid>https://orcid.org/0000-0003-4130-1590</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-690X |
| ispartof | Acta psychiatrica Scandinavica, 2017-05, Vol.135 (5), p.460-469 |
| issn | 0001-690X 1600-0447 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01778330v1 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult affect lability Aged Bipolar disorder Bipolar Disorder - psychology Female Follow-Up Studies Human health and pathology Humans Incidence Life Sciences Male Middle Aged prospective follow‐up study Prospective Studies Psychiatric Status Rating Scales Psychiatrics and mental health Psychopathology Risk Factors Self destructive behavior Suicidal Ideation Suicide, Attempted - psychology Suicide, Attempted - statistics & numerical data Suicides & suicide attempts |
| title | Affect lability predicts occurrence of suicidal ideation in bipolar patients: a two‐year prospective study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T16%3A56%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Affect%20lability%20predicts%20occurrence%20of%20suicidal%20ideation%20in%20bipolar%20patients:%20a%20two%E2%80%90year%20prospective%20study&rft.jtitle=Acta%20psychiatrica%20Scandinavica&rft.au=Ducasse,%20D.&rft.aucorp=FondaMental%20Advanced%20Centers%20of%20Expertise%20in%20Bipolar%20Disorders%20(FACE-BD)%20Collaborators&rft.date=2017-05&rft.volume=135&rft.issue=5&rft.spage=460&rft.epage=469&rft.pages=460-469&rft.issn=0001-690X&rft.eissn=1600-0447&rft_id=info:doi/10.1111/acps.12710&rft_dat=%3Cproquest_hal_p%3E1874785537%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1884389352&rft_id=info:pmid/28260234&rfr_iscdi=true |