Synthesis and cytotoxicity studies of newly designed benzyl-hydroquinone derivatives

Synthesis and cytotoxicity studies of newly designed benzyl-hydroquinone derivatives

A series of new benzyl-substituted hydroquinones has been prepared by short and flexible routes. Such molecules are simplified analogs of bioactive natural terpenes. Preliminary studies have established, for some of these derivatives, promising cytotoxicity data against human carcinoma cancer cell l...

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Veröffentlicht in:Medicinal chemistry research 2018-04, Vol.27 (4), p.1050-1065
Hauptverfasser: Tasseau, Olivier, Mosset, Paul, Barillé-Nion, Sophie, Gautier, Fabien, Juin, Philippe, Levoin, Nicolas, Amireddy, Niharika, Kalivendi, Shasi, Grée, René
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biocompatibility
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chemical Sciences
Cytotoxicity
Derivatives
Hydroquinone
Original Research
Pharmacology/Toxicology
Terpenes
Toxicity
Tumor cell lines
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Zusammenfassung:A series of new benzyl-substituted hydroquinones has been prepared by short and flexible routes. Such molecules are simplified analogs of bioactive natural terpenes. Preliminary studies have established, for some of these derivatives, promising cytotoxicity data against human carcinoma cancer cell lines. Graphical abstract
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-017-2127-z