Familial Aggregation of Insomnia
Abstract Study Objectives: There is little information about familial aggregation of insomnia; however, this type of information is important to (1) improve our understanding of insomnia risk factors and (2) to design more effective treatment and prevention programs. This study aimed to investigate...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2017-02, Vol.40 (2) |
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| container_title | Sleep (New York, N.Y.) |
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| creator | Jarrin, Denise C. Morin, Charles M. Rochefort, Amélie Ivers, Hans Dauvilliers, Yves A. Savard, Josée LeBlanc, Mélanie Merette, Chantal |
| description | Abstract
Study Objectives:
There is little information about familial aggregation of insomnia; however, this type of information is important to (1) improve our understanding of insomnia risk factors and (2) to design more effective treatment and prevention programs. This study aimed to investigate evidence of familial aggregation of insomnia among first-degree relatives of probands with and without insomnia.
Methods:
Cases (n = 134) and controls (n = 145) enrolled in a larger epidemiological study were solicited to invite their first-degree relatives and spouses to complete a standardized sleep/insomnia survey. In total, 371 first-degree relatives (Mage = 51.9 years, SD = 18.0; 34.3% male) and 138 spouses (Mage = 55.5 years, SD = 12.2; 68.1% male) completed the survey assessing the nature, severity, and frequency of sleep disturbances. The dependent variable was insomnia in first-degree relatives and spouses. Familial aggregation was claimed if the risk of insomnia was significantly higher in the exposed (relatives of cases) compared to the unexposed cohort (relatives of controls). The risk of insomnia was also compared between spouses in the exposed (spouses of cases) and unexposed cohort (spouses of controls).
Results:
The risk of insomnia in exposed and unexposed biological relatives was 18.6% and 10.4%, respectively, yielding a relative risk (RR) of 1.80 (p = .04) after controlling for age and sex. The risk of insomnia in exposed and unexposed spouses was 9.1% and 4.2%, respectively; however, corresponding RR of 2.13 (p = .28) did not differ significantly.
Conclusions:
Results demonstrate evidence of strong familial aggregation of insomnia. Additional research is warranted to further clarify and disentangle the relative contribution of genetic and environmental factors in insomnia. |
| doi_str_mv | 10.1093/sleep/zsw053 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01767690v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/sleep/zsw053</oup_id><sourcerecordid>1883182401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-57e33c97e43d6519f18073fe1df1ebe534fbe1c3bc71b96ab9b1b1abf98446863</originalsourceid><addsrcrecordid>eNp90M1LwzAYBvAgipvTm2cZeFDBurzLR5PjGM4NBl70HJIumR1tU5tV0b_ezE4PHjyFJD8e3vdB6BzwHWBJRqGwth59hnfMyAHqA2M4kfHnEPUxcEgEYNZDJyFscLxTSY5RbywIp1TKPhrOdJkXuS6Gk_W6sWu9zX019G64qIIvq1yfoiOni2DP9ucAPc_un6bzZPn4sJhOlklGx2SbsNQSksnUUrLiDKQDgVPiLKwcWGMZoc5YyIjJUjCSayMNGNDGSUEpF5wM0E2X-6ILVTd5qZsP5XWu5pOl2r1hSHnKJX6DaK87Wzf-tbVhq8o8ZLYodGV9GxQIQUCMKd7Ryz9049umipsokIJJFiWN6rZTWeNDaKz7nQCw2rWsvltWXcuRX-xDW1Pa1S_-qTWCqw74tv4_6gv57oQ4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1985958314</pqid></control><display><type>article</type><title>Familial Aggregation of Insomnia</title><source>MEDLINE</source><source>OUP_牛津大学出版社现刊</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Jarrin, Denise C. ; Morin, Charles M. ; Rochefort, Amélie ; Ivers, Hans ; Dauvilliers, Yves A. ; Savard, Josée ; LeBlanc, Mélanie ; Merette, Chantal</creator><creatorcontrib>Jarrin, Denise C. ; Morin, Charles M. ; Rochefort, Amélie ; Ivers, Hans ; Dauvilliers, Yves A. ; Savard, Josée ; LeBlanc, Mélanie ; Merette, Chantal</creatorcontrib><description>Abstract
Study Objectives:
There is little information about familial aggregation of insomnia; however, this type of information is important to (1) improve our understanding of insomnia risk factors and (2) to design more effective treatment and prevention programs. This study aimed to investigate evidence of familial aggregation of insomnia among first-degree relatives of probands with and without insomnia.
Methods:
Cases (n = 134) and controls (n = 145) enrolled in a larger epidemiological study were solicited to invite their first-degree relatives and spouses to complete a standardized sleep/insomnia survey. In total, 371 first-degree relatives (Mage = 51.9 years, SD = 18.0; 34.3% male) and 138 spouses (Mage = 55.5 years, SD = 12.2; 68.1% male) completed the survey assessing the nature, severity, and frequency of sleep disturbances. The dependent variable was insomnia in first-degree relatives and spouses. Familial aggregation was claimed if the risk of insomnia was significantly higher in the exposed (relatives of cases) compared to the unexposed cohort (relatives of controls). The risk of insomnia was also compared between spouses in the exposed (spouses of cases) and unexposed cohort (spouses of controls).
Results:
The risk of insomnia in exposed and unexposed biological relatives was 18.6% and 10.4%, respectively, yielding a relative risk (RR) of 1.80 (p = .04) after controlling for age and sex. The risk of insomnia in exposed and unexposed spouses was 9.1% and 4.2%, respectively; however, corresponding RR of 2.13 (p = .28) did not differ significantly.
Conclusions:
Results demonstrate evidence of strong familial aggregation of insomnia. Additional research is warranted to further clarify and disentangle the relative contribution of genetic and environmental factors in insomnia.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsw053</identifier><identifier>PMID: 28364499</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Case-Control Studies ; Cohort Studies ; Family ; Female ; Heredity ; Human health and pathology ; Humans ; Insomnia ; Life Sciences ; Longitudinal Studies ; Male ; Middle Aged ; Neurons and Cognition ; Risk Factors ; Sleep Initiation and Maintenance Disorders - diagnosis ; Sleep Initiation and Maintenance Disorders - epidemiology ; Sleep Initiation and Maintenance Disorders - genetics ; Sleep Wake Disorders - diagnosis ; Sleep Wake Disorders - epidemiology ; Sleep Wake Disorders - genetics ; Spouses ; Surveys and Questionnaires</subject><ispartof>Sleep (New York, N.Y.), 2017-02, Vol.40 (2)</ispartof><rights>Sleep Research Society 2016. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com. 2016</rights><rights>Sleep Research Society 2016. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.</rights><rights>Copyright © 2016 Sleep Research Society</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-57e33c97e43d6519f18073fe1df1ebe534fbe1c3bc71b96ab9b1b1abf98446863</citedby><cites>FETCH-LOGICAL-c423t-57e33c97e43d6519f18073fe1df1ebe534fbe1c3bc71b96ab9b1b1abf98446863</cites><orcidid>0000-0003-0683-6506</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28364499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01767690$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Jarrin, Denise C.</creatorcontrib><creatorcontrib>Morin, Charles M.</creatorcontrib><creatorcontrib>Rochefort, Amélie</creatorcontrib><creatorcontrib>Ivers, Hans</creatorcontrib><creatorcontrib>Dauvilliers, Yves A.</creatorcontrib><creatorcontrib>Savard, Josée</creatorcontrib><creatorcontrib>LeBlanc, Mélanie</creatorcontrib><creatorcontrib>Merette, Chantal</creatorcontrib><title>Familial Aggregation of Insomnia</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>Abstract
Study Objectives:
There is little information about familial aggregation of insomnia; however, this type of information is important to (1) improve our understanding of insomnia risk factors and (2) to design more effective treatment and prevention programs. This study aimed to investigate evidence of familial aggregation of insomnia among first-degree relatives of probands with and without insomnia.
Methods:
Cases (n = 134) and controls (n = 145) enrolled in a larger epidemiological study were solicited to invite their first-degree relatives and spouses to complete a standardized sleep/insomnia survey. In total, 371 first-degree relatives (Mage = 51.9 years, SD = 18.0; 34.3% male) and 138 spouses (Mage = 55.5 years, SD = 12.2; 68.1% male) completed the survey assessing the nature, severity, and frequency of sleep disturbances. The dependent variable was insomnia in first-degree relatives and spouses. Familial aggregation was claimed if the risk of insomnia was significantly higher in the exposed (relatives of cases) compared to the unexposed cohort (relatives of controls). The risk of insomnia was also compared between spouses in the exposed (spouses of cases) and unexposed cohort (spouses of controls).
Results:
The risk of insomnia in exposed and unexposed biological relatives was 18.6% and 10.4%, respectively, yielding a relative risk (RR) of 1.80 (p = .04) after controlling for age and sex. The risk of insomnia in exposed and unexposed spouses was 9.1% and 4.2%, respectively; however, corresponding RR of 2.13 (p = .28) did not differ significantly.
Conclusions:
Results demonstrate evidence of strong familial aggregation of insomnia. Additional research is warranted to further clarify and disentangle the relative contribution of genetic and environmental factors in insomnia.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Family</subject><subject>Female</subject><subject>Heredity</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Insomnia</subject><subject>Life Sciences</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurons and Cognition</subject><subject>Risk Factors</subject><subject>Sleep Initiation and Maintenance Disorders - diagnosis</subject><subject>Sleep Initiation and Maintenance Disorders - epidemiology</subject><subject>Sleep Initiation and Maintenance Disorders - genetics</subject><subject>Sleep Wake Disorders - diagnosis</subject><subject>Sleep Wake Disorders - epidemiology</subject><subject>Sleep Wake Disorders - genetics</subject><subject>Spouses</subject><subject>Surveys and Questionnaires</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90M1LwzAYBvAgipvTm2cZeFDBurzLR5PjGM4NBl70HJIumR1tU5tV0b_ezE4PHjyFJD8e3vdB6BzwHWBJRqGwth59hnfMyAHqA2M4kfHnEPUxcEgEYNZDJyFscLxTSY5RbywIp1TKPhrOdJkXuS6Gk_W6sWu9zX019G64qIIvq1yfoiOni2DP9ucAPc_un6bzZPn4sJhOlklGx2SbsNQSksnUUrLiDKQDgVPiLKwcWGMZoc5YyIjJUjCSayMNGNDGSUEpF5wM0E2X-6ILVTd5qZsP5XWu5pOl2r1hSHnKJX6DaK87Wzf-tbVhq8o8ZLYodGV9GxQIQUCMKd7Ryz9049umipsokIJJFiWN6rZTWeNDaKz7nQCw2rWsvltWXcuRX-xDW1Pa1S_-qTWCqw74tv4_6gv57oQ4</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Jarrin, Denise C.</creator><creator>Morin, Charles M.</creator><creator>Rochefort, Amélie</creator><creator>Ivers, Hans</creator><creator>Dauvilliers, Yves A.</creator><creator>Savard, Josée</creator><creator>LeBlanc, Mélanie</creator><creator>Merette, Chantal</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-0683-6506</orcidid></search><sort><creationdate>20170201</creationdate><title>Familial Aggregation of Insomnia</title><author>Jarrin, Denise C. ; Morin, Charles M. ; Rochefort, Amélie ; Ivers, Hans ; Dauvilliers, Yves A. ; Savard, Josée ; LeBlanc, Mélanie ; Merette, Chantal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-57e33c97e43d6519f18073fe1df1ebe534fbe1c3bc71b96ab9b1b1abf98446863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Family</topic><topic>Female</topic><topic>Heredity</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Insomnia</topic><topic>Life Sciences</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurons and Cognition</topic><topic>Risk Factors</topic><topic>Sleep Initiation and Maintenance Disorders - diagnosis</topic><topic>Sleep Initiation and Maintenance Disorders - epidemiology</topic><topic>Sleep Initiation and Maintenance Disorders - genetics</topic><topic>Sleep Wake Disorders - diagnosis</topic><topic>Sleep Wake Disorders - epidemiology</topic><topic>Sleep Wake Disorders - genetics</topic><topic>Spouses</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jarrin, Denise C.</creatorcontrib><creatorcontrib>Morin, Charles M.</creatorcontrib><creatorcontrib>Rochefort, Amélie</creatorcontrib><creatorcontrib>Ivers, Hans</creatorcontrib><creatorcontrib>Dauvilliers, Yves A.</creatorcontrib><creatorcontrib>Savard, Josée</creatorcontrib><creatorcontrib>LeBlanc, Mélanie</creatorcontrib><creatorcontrib>Merette, Chantal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Health and Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest_Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jarrin, Denise C.</au><au>Morin, Charles M.</au><au>Rochefort, Amélie</au><au>Ivers, Hans</au><au>Dauvilliers, Yves A.</au><au>Savard, Josée</au><au>LeBlanc, Mélanie</au><au>Merette, Chantal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Familial Aggregation of Insomnia</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>40</volume><issue>2</issue><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Study Objectives:
There is little information about familial aggregation of insomnia; however, this type of information is important to (1) improve our understanding of insomnia risk factors and (2) to design more effective treatment and prevention programs. This study aimed to investigate evidence of familial aggregation of insomnia among first-degree relatives of probands with and without insomnia.
Methods:
Cases (n = 134) and controls (n = 145) enrolled in a larger epidemiological study were solicited to invite their first-degree relatives and spouses to complete a standardized sleep/insomnia survey. In total, 371 first-degree relatives (Mage = 51.9 years, SD = 18.0; 34.3% male) and 138 spouses (Mage = 55.5 years, SD = 12.2; 68.1% male) completed the survey assessing the nature, severity, and frequency of sleep disturbances. The dependent variable was insomnia in first-degree relatives and spouses. Familial aggregation was claimed if the risk of insomnia was significantly higher in the exposed (relatives of cases) compared to the unexposed cohort (relatives of controls). The risk of insomnia was also compared between spouses in the exposed (spouses of cases) and unexposed cohort (spouses of controls).
Results:
The risk of insomnia in exposed and unexposed biological relatives was 18.6% and 10.4%, respectively, yielding a relative risk (RR) of 1.80 (p = .04) after controlling for age and sex. The risk of insomnia in exposed and unexposed spouses was 9.1% and 4.2%, respectively; however, corresponding RR of 2.13 (p = .28) did not differ significantly.
Conclusions:
Results demonstrate evidence of strong familial aggregation of insomnia. Additional research is warranted to further clarify and disentangle the relative contribution of genetic and environmental factors in insomnia.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>28364499</pmid><doi>10.1093/sleep/zsw053</doi><orcidid>https://orcid.org/0000-0003-0683-6506</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; OUP_牛津大学出版社现刊; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Case-Control Studies Cohort Studies Family Female Heredity Human health and pathology Humans Insomnia Life Sciences Longitudinal Studies Male Middle Aged Neurons and Cognition Risk Factors Sleep Initiation and Maintenance Disorders - diagnosis Sleep Initiation and Maintenance Disorders - epidemiology Sleep Initiation and Maintenance Disorders - genetics Sleep Wake Disorders - diagnosis Sleep Wake Disorders - epidemiology Sleep Wake Disorders - genetics Spouses Surveys and Questionnaires |
| title | Familial Aggregation of Insomnia |
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