Frequent c-fms activation by proviral insertion in mouse myeloblastic leukaemias

Retroviruses lacking oncogenes can induce tumours in animals, and the tumour cells are frequently found to contain proviral DNA inserted next to a proto-oncogene, which is thus placed under the regulatory control of the retroviral long terminal repeat (LTR). This altered regulation leads to overexpr...

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Veröffentlicht in:	Nature (London) 1987-09, Vol.329 (6136), p.259-261
Hauptverfasser:	Gisselbrecht, Sylvie, Fichelson, Serge, Sola, Brigitte, Bordereaux, Didier, Hampe, Annie, André, Catherine, Galibert, Francis, Tambourin, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Base Sequence Biological and medical sciences Cell Transformation, Neoplastic Deoxyribonucleic acid DNA DNA, Neoplasm - genetics DNA, Viral - genetics Experimental malignant blood diseases Friend murine leukemia virus - genetics Gene Expression Regulation Genetics Growth Substances - genetics Humanities and Social Sciences Humans letter Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - microbiology Life Sciences Medical disorders Medical research Medical sciences Mice multidisciplinary Nucleic Acid Hybridization Proto-Oncogenes Retrovirus RNA, Messenger - genetics Science Science (multidisciplinary) Tumors Viruses
Online-Zugang:	Volltext
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