The Selective Estrogen Receptor Modulator 4-Hydroxy Tamoxifen Induces G1 Arrest and Apoptosis of Multiple Myeloma Cell Lines
: Multiple myeloma (MM) is an incurable hematological malignancy for which new therapeutic strategies should be envisaged. The selective estrogen receptor modulator (SERM), 4‐hydroxy tamoxifen (4‐OHTam), in the range of 1 to 10 μM, was able to impair the cell proliferation of MM cell lines. This was...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2003-12, Vol.1010 (1), p.321-325 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | GAUDUCHON, JULIETTE GOUILLEUX, FABRICE MAILLARD, SÉBASTIEN MARSAUD, VÉRONIQUE RENOIR, MICHEL J. SOLA, BRIGITTE |
| description | : Multiple myeloma (MM) is an incurable hematological malignancy for which new therapeutic strategies should be envisaged. The selective estrogen receptor modulator (SERM), 4‐hydroxy tamoxifen (4‐OHTam), in the range of 1 to 10 μM, was able to impair the cell proliferation of MM cell lines. This was achieved by blocking cells at the G1 phase of the cell cycle and by inducing apoptosis. This cellular response was observed in five out of six tested cell lines, all five expressing both α and β estrogen receptor forms. No modifications of Bcl‐2, Bcl‐X, and Bax levels were observed, as well as no changes in Pi3K/Akt and JAK/STAT pathways that are often constitutively active in these cells. The signalization of 4‐OHTam‐induced cell death needs further investigation. |
| doi_str_mv | 10.1196/annals.1299.057 |
| format | Article |
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The selective estrogen receptor modulator (SERM), 4‐hydroxy tamoxifen (4‐OHTam), in the range of 1 to 10 μM, was able to impair the cell proliferation of MM cell lines. This was achieved by blocking cells at the G1 phase of the cell cycle and by inducing apoptosis. This cellular response was observed in five out of six tested cell lines, all five expressing both α and β estrogen receptor forms. No modifications of Bcl‐2, Bcl‐X, and Bax levels were observed, as well as no changes in Pi3K/Akt and JAK/STAT pathways that are often constitutively active in these cells. The signalization of 4‐OHTam‐induced cell death needs further investigation.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1196/annals.1299.057</identifier><identifier>PMID: 15033743</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>apoptosis ; Apoptosis - drug effects ; Bcl-2 family ; cell cycle ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; G1 Phase - drug effects ; Humans ; Kinetics ; Life Sciences ; Multiple Myeloma ; p53 ; Receptors, Estrogen - antagonists & inhibitors ; survival pathway ; Tamoxifen - analogs & derivatives ; Tamoxifen - pharmacology</subject><ispartof>Annals of the New York Academy of Sciences, 2003-12, Vol.1010 (1), p.321-325</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4511-ad95bfa51042c1da5d2965d7ff6fbaf40373a95ead8db3fd67cb192c814dec2f3</citedby><cites>FETCH-LOGICAL-c4511-ad95bfa51042c1da5d2965d7ff6fbaf40373a95ead8db3fd67cb192c814dec2f3</cites><orcidid>0000-0001-6047-1718 ; 0000-0001-7278-9651</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1196%2Fannals.1299.057$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1196%2Fannals.1299.057$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15033743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://normandie-univ.hal.science/hal-01762034$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>GAUDUCHON, JULIETTE</creatorcontrib><creatorcontrib>GOUILLEUX, FABRICE</creatorcontrib><creatorcontrib>MAILLARD, SÉBASTIEN</creatorcontrib><creatorcontrib>MARSAUD, VÉRONIQUE</creatorcontrib><creatorcontrib>RENOIR, MICHEL J.</creatorcontrib><creatorcontrib>SOLA, BRIGITTE</creatorcontrib><title>The Selective Estrogen Receptor Modulator 4-Hydroxy Tamoxifen Induces G1 Arrest and Apoptosis of Multiple Myeloma Cell Lines</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: Multiple myeloma (MM) is an incurable hematological malignancy for which new therapeutic strategies should be envisaged. The selective estrogen receptor modulator (SERM), 4‐hydroxy tamoxifen (4‐OHTam), in the range of 1 to 10 μM, was able to impair the cell proliferation of MM cell lines. This was achieved by blocking cells at the G1 phase of the cell cycle and by inducing apoptosis. This cellular response was observed in five out of six tested cell lines, all five expressing both α and β estrogen receptor forms. No modifications of Bcl‐2, Bcl‐X, and Bax levels were observed, as well as no changes in Pi3K/Akt and JAK/STAT pathways that are often constitutively active in these cells. The signalization of 4‐OHTam‐induced cell death needs further investigation.</description><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bcl-2 family</subject><subject>cell cycle</subject><subject>Cell Line, Tumor</subject><subject>Dose-Response Relationship, Drug</subject><subject>G1 Phase - drug effects</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Life Sciences</subject><subject>Multiple Myeloma</subject><subject>p53</subject><subject>Receptors, Estrogen - antagonists & inhibitors</subject><subject>survival pathway</subject><subject>Tamoxifen - analogs & derivatives</subject><subject>Tamoxifen - pharmacology</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9v0zAYhiMEYmVw5oZ8QuKQzr8SN8dQjXaoHRIrQ5wsJ_7MAk4c7GRrpP3xJEo1jpxsWc_76rWeKHpL8JKQLL1QTaNsWBKaZUuciGfRggiexWnK6PNogbEQ8Sqj7Cx6FcIvjAldcfEyOiMJZkxwtogeD3eAbsBC2VX3gC5D591PaNBXKKHtnEd7p3urphuPt4P27jigg6rdsTIjdtXovoSANgTl3kPokGo0yls3ZkMVkDNo39uuai2g_QDW1QqtwVq0qxoIr6MXZpwPb07nefTt0-VhvY13XzZX63wXlzwhJFY6SwqjEoI5LYlWiaZZmmhhTGoKZThmgqksAaVXumBGp6IsSEbLFeEaSmrYefRh7r1TVra-qpUfpFOV3OY7Ob1hIlKKGb8nI_t-Zlvv_vTjj2RdhXKcrBpwfZCCJCmnAo_gxQyW3oXgwTw1EywnOXKWIyc5cpQzJt6dqvuiBv2PP9kYAT4DD5WF4X998vpHfsPoNDmeY1Xo4PgUU_63TAUTifx-vZHp7cfbzWeyl4L9BSBVrMU</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>GAUDUCHON, JULIETTE</creator><creator>GOUILLEUX, FABRICE</creator><creator>MAILLARD, SÉBASTIEN</creator><creator>MARSAUD, VÉRONIQUE</creator><creator>RENOIR, MICHEL J.</creator><creator>SOLA, BRIGITTE</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-6047-1718</orcidid><orcidid>https://orcid.org/0000-0001-7278-9651</orcidid></search><sort><creationdate>200312</creationdate><title>The Selective Estrogen Receptor Modulator 4-Hydroxy Tamoxifen Induces G1 Arrest and Apoptosis of Multiple Myeloma Cell Lines</title><author>GAUDUCHON, JULIETTE ; GOUILLEUX, FABRICE ; MAILLARD, SÉBASTIEN ; MARSAUD, VÉRONIQUE ; RENOIR, MICHEL J. ; SOLA, BRIGITTE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4511-ad95bfa51042c1da5d2965d7ff6fbaf40373a95ead8db3fd67cb192c814dec2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bcl-2 family</topic><topic>cell cycle</topic><topic>Cell Line, Tumor</topic><topic>Dose-Response Relationship, Drug</topic><topic>G1 Phase - drug effects</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Life Sciences</topic><topic>Multiple Myeloma</topic><topic>p53</topic><topic>Receptors, Estrogen - antagonists & inhibitors</topic><topic>survival pathway</topic><topic>Tamoxifen - analogs & derivatives</topic><topic>Tamoxifen - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GAUDUCHON, JULIETTE</creatorcontrib><creatorcontrib>GOUILLEUX, FABRICE</creatorcontrib><creatorcontrib>MAILLARD, SÉBASTIEN</creatorcontrib><creatorcontrib>MARSAUD, VÉRONIQUE</creatorcontrib><creatorcontrib>RENOIR, MICHEL J.</creatorcontrib><creatorcontrib>SOLA, BRIGITTE</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GAUDUCHON, JULIETTE</au><au>GOUILLEUX, FABRICE</au><au>MAILLARD, SÉBASTIEN</au><au>MARSAUD, VÉRONIQUE</au><au>RENOIR, MICHEL J.</au><au>SOLA, BRIGITTE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Selective Estrogen Receptor Modulator 4-Hydroxy Tamoxifen Induces G1 Arrest and Apoptosis of Multiple Myeloma Cell Lines</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2003-12</date><risdate>2003</risdate><volume>1010</volume><issue>1</issue><spage>321</spage><epage>325</epage><pages>321-325</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: Multiple myeloma (MM) is an incurable hematological malignancy for which new therapeutic strategies should be envisaged. The selective estrogen receptor modulator (SERM), 4‐hydroxy tamoxifen (4‐OHTam), in the range of 1 to 10 μM, was able to impair the cell proliferation of MM cell lines. This was achieved by blocking cells at the G1 phase of the cell cycle and by inducing apoptosis. This cellular response was observed in five out of six tested cell lines, all five expressing both α and β estrogen receptor forms. No modifications of Bcl‐2, Bcl‐X, and Bax levels were observed, as well as no changes in Pi3K/Akt and JAK/STAT pathways that are often constitutively active in these cells. The signalization of 4‐OHTam‐induced cell death needs further investigation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15033743</pmid><doi>10.1196/annals.1299.057</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-6047-1718</orcidid><orcidid>https://orcid.org/0000-0001-7278-9651</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of the New York Academy of Sciences, 2003-12, Vol.1010 (1), p.321-325 |
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| subjects | apoptosis Apoptosis - drug effects Bcl-2 family cell cycle Cell Line, Tumor Dose-Response Relationship, Drug G1 Phase - drug effects Humans Kinetics Life Sciences Multiple Myeloma p53 Receptors, Estrogen - antagonists & inhibitors survival pathway Tamoxifen - analogs & derivatives Tamoxifen - pharmacology |
| title | The Selective Estrogen Receptor Modulator 4-Hydroxy Tamoxifen Induces G1 Arrest and Apoptosis of Multiple Myeloma Cell Lines |
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