Improved antitumoral properties of pure antiestrogen RU 58668-loaded liposomes in multiple myeloma

In most of multiple myeloma (MM) cells, the “pure” antiestrogen (AE) RU 58668 (RU) induced either a G1-arrest (LP-1, OPM-2, NCI-H929, U266 cells) or apoptosis (RPMI 8226 cells). In RPMI 8226 cells, RU activates a caspase-dependent cell death pathway leading to the release of cytochrome c, the decrea...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2006-07, Vol.100 (1), p.67-78
Hauptverfasser:	Maillard, Sébastien, Gauduchon, Juliette, Marsaud, Véronique, Gouilleux, Fabrice, Connault, Elisabeth, Opolon, Paule, Fattal, Elias, Sola, Brigitte, Renoir, Jack-Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiestrogen delivery Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects B-Lymphocytes - cytology B-Lymphocytes - drug effects Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Cells, Cultured Delayed-Action Preparations Delivery. Postpartum. Lactation Drug Delivery Systems - methods Estradiol - analogs & derivatives Estradiol - isolation & purification Estradiol - pharmacology Estrogen Antagonists - isolation & purification Estrogen Antagonists - pharmacology Estrogen Receptor Modulators - administration & dosage Estrogen Receptor Modulators - pharmacology Female Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Hematologic and hematopoietic diseases Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunohistochemistry Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Life Sciences Liposomes Medical sciences Mice Mice, Nude Models, Biological Multiple Myeloma - drug therapy Multiple Myeloma - pathology Myeloma Palatine Tonsil - cytology Vertebrates: endocrinology Xenograft Model Antitumor Assays
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