Bullous pemphigoid outcome is associated with CXCL10-induced matrix metalloproteinase 9 secretion from monocytes and neutrophils but not lymphocytes

Background The outcome of bullous pemphigoid (BP), the most frequent autoimmune skin-blistering disease, involves matrix metalloproteinase 9 (MMP-9), IL-17, and IL-23 release from infiltrated inflammatory cells. The chemokine CXCL10 has been associated with several autoimmune diseases, but its parti...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2017-03, Vol.139 (3), p.863-872.e3
Hauptverfasser:	Riani, Meriem, MSc, Le Jan, Sébastien, PhD, Plée, Julie, MD, Durlach, Anne, MD, PhD, Le Naour, Richard, PhD, Haegeman, Guy, PhD, Bernard, Philippe, MD, PhD, Antonicelli, Frank, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Allergy and Immunology Autoimmune diseases autoimmunity Blister - immunology Bullous pemphigoid Cell Line Cells, Cultured Chemokine CXCL10 - immunology compound A CXCL10 Cytokines Dermatology Disease Female Fibroblasts Fluids Humans Immunology inflammation Laboratories Life Sciences Lymphocytes Lymphocytes - immunology Male Matrix Metalloproteinase 9 - immunology Middle Aged Monocytes - immunology Neutrophils Neutrophils - immunology Pemphigoid, Bullous - immunology selective glucocorticoid receptor activator Skin - immunology
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