Strategies For Immobilization Of Bioactive Organic Molecules On Titanium Implant Surfaces - A Review

Numerous approaches have been used to improve the tissue-implant interface of titanium (Ti) and titanium alloy (Ti6Al4V). They all aim at increasing cell migration and attachment to the metal, preventing unspecific protein adsorption and improving post-implantation healing process. Promising methods...

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Veröffentlicht in:Folia Medica 2015-01, Vol.57 (1), p.11-18
Hauptverfasser: Panayotov, Ivan V, Vladimirov, Boyan S, Dutilleul, Pierre-Yves C, Levallois, Bernard, Cuisinier, Frédéric
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container_issue 1
container_start_page 11
container_title Folia Medica
container_volume 57
creator Panayotov, Ivan V
Vladimirov, Boyan S
Dutilleul, Pierre-Yves C
Levallois, Bernard
Cuisinier, Frédéric
description Numerous approaches have been used to improve the tissue-implant interface of titanium (Ti) and titanium alloy (Ti6Al4V). They all aim at increasing cell migration and attachment to the metal, preventing unspecific protein adsorption and improving post-implantation healing process. Promising methods for titanium and titanium alloy surface modification are based on the immobilization of biologically active organic molecules. New and interesting biochemical approaches to such surface modification include layer-by-layer deposition of polyelectrolyte films, phage display-selected surface binding peptides and self-assembled DNA monolayer systems. The present review summarizes the scientific information about these methods, which are at in vitro or in vivo development stages, and hopes to promote their future application in dental implantology and in oral and maxillofacial surgery.
doi_str_mv 10.1515/folmed-2015-0014
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subjects Adsorption
Amino Acid Sequence
Bioengineering
Biomaterials
Blood Proteins - chemistry
Dental Implants
DNA monolayers
Immobilized Proteins - chemistry
Life Sciences
metal-binding peptides
Molecular Sequence Data
polyelectrolyte multi-layers
surface functionalization
Surface Properties
Titanium
titanium implants
ДНК единичные слои
полиэлектролитные мультислои
связывающие металл пептиды
титановые имплантаты
функционализация поверхностей
title Strategies For Immobilization Of Bioactive Organic Molecules On Titanium Implant Surfaces - A Review
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