Cellular localisation of a water-soluble fullerene derivative
Fullerenes are a new class of compounds with potential uses in biology and medicine and many insights were made in the knowledge of their interaction with various biological systems. However, their interaction with organised living systems as well as the site of their potential action remains unclea...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2002-05, Vol.294 (1), p.116-119 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Foley, Sarah Crowley, Colin Smaihi, Monique Bonfils, Claude Erlanger, Bernard F Seta, Patrick Larroque, Christian |
| description | Fullerenes are a new class of compounds with potential uses in biology and medicine and many insights were made in the knowledge of their interaction with various biological systems. However, their interaction with organised living systems as well as the site of their potential action remains unclear. In this work, we have demonstrated that a fullerene derivative could cross the external cellular membrane and it localises preferentially to the mitochondria. We propose that our finding supports the potential use of fullerenes as drug delivery agents as their structure mimics that of clathrin known to mediate endocytosis. |
| doi_str_mv | 10.1016/S0006-291X(02)00445-X |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Biochemical and biophysical research communications, 2002-05, Vol.294 (1), p.116-119 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Carbon - chemistry Carbon - metabolism Cell Membrane - metabolism Cells, Cultured Chemical Sciences COS Cells Drug Delivery Systems Fluorescent Antibody Technique, Indirect Fullerenes Humans Magnetic Resonance Spectroscopy Microscopy, Fluorescence Mitochondria - metabolism Solubility Structure-Activity Relationship Water |
| title | Cellular localisation of a water-soluble fullerene derivative |
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