Designing N-Heterocyclic Carbenes: Simultaneous Enhancement of Reactivity and Enantioselectivity in the Asymmetric Hydroacylation of Cyclopropenes

Faster, higher, stronger! The N‐heterocyclic carbene (NHC) catalyzed diastereo‐ and enantioselective hydroacylation of cyclopropenes affords structurally valuable acylcyclopropanes. A new family of electron‐rich, 2,6‐dimethoxyphenyl‐substituted NHCs induces excellent reactivity and enantioselectivit...

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Veröffentlicht in:	Angewandte Chemie International Edition 2011-12, Vol.50 (52), p.12626-12630
Hauptverfasser:	Liu, Fan, Bugaut, Xavier, Schedler, Michael, Fröhlich, Roland, Glorius, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Asymmetry Carbenes Catalysis Catalysts Chemical Sciences Crystallography, X-Ray Cyclopropanes - chemical synthesis Cyclopropanes - chemistry cyclopropenes enantioselective catalysis Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry hydroacylation Methane - analogs & derivatives Methane - chemical synthesis Methane - chemistry Models, Molecular Molecular Structure N-heterocyclic carbenes Organic chemistry Organic compounds organocatalysis Reaction kinetics Stereoisomerism Transformations
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