Cytoplasmic overexpression of RNA‐binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia

HuR regulates cytoplasmic mRNA stability and translatability, and the HuR expression level has been shown to correlate with poor disease outcome in several cancer types; however, the prognostic value and potential pro‐oncogenic properties of HuR in meningioma remain unclear. Thus, in the present stu...

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Veröffentlicht in:	Journal of pathology and bacteriology 2017-08, Vol.242 (4), p.421-434
Hauptverfasser:	Gauchotte, Guillaume, Hergalant, Sébastien, Vigouroux, Charlène, Casse, Jean‐Matthieu, Houlgatte, Rémi, Kaoma, Tony, Helle, Déborah, Brochin, Lydia, Rech, Fabien, Peyre, Matthieu, Labrousse, François, Vallar, Laurent, Guéant, Jean‐Louis, Vignaud, Jean‐Michel, Battaglia‐Hsu, Shyue‐Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Apoptosis Apoptosis - physiology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain cancer Cancer Cell culture Cell cycle Cell Division Cell growth Cell Hypoxia - physiology Cell Line, Tumor Cell lines Cell proliferation Cytoplasm - metabolism ELAV-Like Protein 1 - deficiency ELAV-Like Protein 1 - genetics ELAV-Like Protein 1 - metabolism ELAV‐like 1 Female Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - physiology Gene Knockdown Techniques Genomes Humans HuR HuR protein Hypoxia Kaplan-Meier Estimate Life Sciences Male Medical prognosis Meningioma Meningioma - genetics Meningioma - metabolism Meningioma - pathology Middle Aged mRNA processing mRNA stability Neoplasm Grading Neoplasm Proteins - deficiency Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Observer Variation Poly(A)-specific ribonuclease Polyadenine Prognosis proliferation Regulations Retrospective Studies RNA-binding protein RNA-Binding Proteins - metabolism Signal transduction Splicing Survival Tissues Tumors Up-Regulation - physiology
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