Genetic determined low response to thienopyridines is associated with higher systemic inflammation in smokers

: To investigate whether the interactions of and with smoking are associated with the levels of P2Y12 receptor inhibition and CRP, in on-thienopyridine post-stenting patients. : At 1-month follow-up, the interactions of smoking and polymorphisms on the vasodilator-stimulated phosphoprotein - platele...

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Veröffentlicht in:	Pharmacogenomics 2015-04, Vol.16 (5), p.459-469
Hauptverfasser:	Shahabi, Payman, Cuisset, Thomas, Stathopoulou, Maria G, Morange, Pierre Emmanuel, Grosdidier, Charlotte, Herbeth, Bernard, Siest, Gérard, Alessi, Marie-Christine, Visvikis-Siest, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged C-Reactive Protein - genetics clopidogrel CRP Cytochrome P-450 CYP2C19 - genetics cytochrome P450 Drug metabolism Drug therapy Female Genetic aspects Genetic polymorphisms Genetics Genotype Health aspects Heterozygote Human genetics Humans Inflammation - genetics Life Sciences Male Middle Aged Patient outcomes Phosphoproteins - metabolism Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - therapeutic use prasugrel Purinergic P2Y Receptor Antagonists - adverse effects Purinergic P2Y Receptor Antagonists - therapeutic use Smoking Smoking - genetics Stents Thienopyridines Thienopyridines - adverse effects Thienopyridines - therapeutic use Vasodilation - physiology
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