Design, synthesis and docking study of novel tetracyclic oxindole derivatives as α-glucosidase inhibitors

[Display omitted] A series of novel tetracyclic oxindole derivatives were synthesized via tandem Suzuki coupling–Michael addition reaction catalyzed by palladium. Twenty derivatives were designed and synthesized in 6–8 steps in 8–20% overall yields. Their structures were confirmed by 1H, 13C NMR and...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-04, Vol.25 (7), p.1471-1475
Hauptverfasser:	Han, Kailin, Li, Yashan, Zhang, Yazhou, Teng, Yuou, Ma, Ying, Wang, Meiyan, Wang, Runling, Xu, Weiren, Yao, Qingwei, Zhang, Yongmin, Qin, Haijuan, Sun, Hua, Yu, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Glucosidases - metabolism Chemical Sciences Docking study Dose-Response Relationship, Drug Drug Design Glycoside Hydrolase Inhibitors - chemical synthesis Glycoside Hydrolase Inhibitors - chemistry Glycoside Hydrolase Inhibitors - pharmacology Indole Alkaloids - chemical synthesis Indole Alkaloids - chemistry Indole Alkaloids - pharmacology Molecular Docking Simulation Molecular Structure Phenanthridine derivatives SAR study Structure-Activity Relationship Tetracyclic isatins α-Glucosidase inhibitors
Online-Zugang:	Volltext
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