CK2 accumulation at the axon initial segment depends on sodium channel Nav1

•Phosphorylation of Nav1 ankyrin-binding motif occurs in vivo.•Nav1 expression is necessary for CK2 localization at the AIS.•CK2-Nav1 molecular complex modulates CK2-clustering at the AIS. Accumulation of voltage-gated sodium channel Nav1 at the axon initial segment (AIS), results from a direct inte...

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Veröffentlicht in:	FEBS letters 2014-09, Vol.588 (18), p.3403-3408
Hauptverfasser:	Hien, Y.E., Montersino, A., Castets, F., Leterrier, C., Filhol, O., Vacher, H., Dargent, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Axon initial segment Axons - enzymology Casein Kinase II - metabolism Cells, Cultured Dominant negative Gene Expression Hippocampus - cytology Life Sciences Nav1 NAV1.2 Voltage-Gated Sodium Channel - genetics NAV1.2 Voltage-Gated Sodium Channel - metabolism Neurobiology Neurons and Cognition Phosphorylation Phosphospecific antibody Protein kinase CK2 Protein Processing, Post-Translational Protein Transport Rats Rats, Wistar
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