Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media and Biological Fluids Due to Decreased Expression of oprM and Increased Outer-Membrane Permeability

Background. Macrolides show high minimum inhibitory concentrations (MICs) against Pseudomonas aeruginosa when tested in recommended media (cation-adjusted Muller-Hinton broth [CA-MHB]). Nevertheless, azithromycin is successfully used in cystic fibrosis patients, supposedly because of "nonantibi...

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Veröffentlicht in:	Clinical infectious diseases 2012-08, Vol.55 (4), p.534-542
Hauptverfasser:	Buyck, Julien M., Plésiat, Patrick, Traore, H., Vanderbist, F., Tulkens, Paul M., Van Bambeke, Françoise
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents ARTICLES AND COMMENTARIES Azithromycin - pharmacology Bacteria Bacterial Outer Membrane Proteins - biosynthesis Bacterial Outer Membrane Proteins - metabolism Bacteriology Biological and medical sciences Bronchoalveolar Lavage Fluid Cell Membrane Permeability - drug effects Culture Media Dipeptides - pharmacology Eukaryotes Eukaryotic cells Fluid permeability Gene expression Gram-negative bacteria Hydrogen-Ion Concentration Infectious diseases Ketolides Ketolides - pharmacology Life Sciences Macrolides Medical sciences Membrane Transport Proteins - biosynthesis Membrane Transport Proteins - deficiency Membrane Transport Proteins - metabolism Membranes Mice Microbial Sensitivity Tests Microbiology and Parasitology Models, Biological Pharmacology. Drug treatments Polymerase chain reaction Protein synthesis Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - metabolism Pumps
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