Biochip based on arrays of switchable magnetic nano-traps
•Magnetic biochips based on switchable magnetic nano-traps were developed.•They were optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution.•The presence of synthetic peptides trapped on the magnetic wire was revealed via...
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| Veröffentlicht in: | Sensors and actuators. B, Chemical Chemical, 2017-11, Vol.251, p.699-705 |
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| container_title | Sensors and actuators. B, Chemical |
| container_volume | 251 |
| creator | Vautrin, Christopher Vyazmensky, Maria Engel, Stanislav Murtry, Stephan Mc Hehn, Michel Montaigne, François Lacour, Daniel Marks, Robert S. |
| description | •Magnetic biochips based on switchable magnetic nano-traps were developed.•They were optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution.•The presence of synthetic peptides trapped on the magnetic wire was revealed via fluorescently labeled immunoglobulins.
Magnetic biochips based on switchable magnetic nano-traps were developed and optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution. Nano-traps are based on snake shaped magnetic nanowires made by microelectronic technics from a thin magnetic layer. This optimized design ensures high local fields when the trap is activated and reduced stray fields when deactivated with respect to previous designs. Our proof-of-concept model consists to determine the anchorage of synthetic peptides in a bilayer enveloping magnetic beads by revealing their presence via fluorescently labeled immunoglobulins elicited against the native proteins of the said exposed peptides. |
| doi_str_mv | 10.1016/j.snb.2017.05.084 |
| format | Article |
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Magnetic biochips based on switchable magnetic nano-traps were developed and optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution. Nano-traps are based on snake shaped magnetic nanowires made by microelectronic technics from a thin magnetic layer. This optimized design ensures high local fields when the trap is activated and reduced stray fields when deactivated with respect to previous designs. Our proof-of-concept model consists to determine the anchorage of synthetic peptides in a bilayer enveloping magnetic beads by revealing their presence via fluorescently labeled immunoglobulins elicited against the native proteins of the said exposed peptides.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.snb.2017.05.084</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4240-5925</orcidid><orcidid>https://orcid.org/0000-0002-9697-3805</orcidid><orcidid>https://orcid.org/0000-0003-4010-9935</orcidid><orcidid>https://orcid.org/0000-0002-5871-8870</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Sensors and actuators. B, Chemical, 2017-11, Vol.251, p.699-705 |
| issn | 0925-4005 1873-3077 |
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| source | ScienceDirect Freedom Collection (Elsevier) |
| subjects | Bio-assay Biochemistry Biochemistry, Molecular Biology Condensed Matter Life Sciences Magnetic beads Magnetic domains walls Magnetic nano-traps Materials Science Peptide Physics |
| title | Biochip based on arrays of switchable magnetic nano-traps |
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