Synthesis, Radiofluorination, and in Vivo Evaluation of Novel Fluorinated and Iodinated Radiotracers for PET Imaging and Targeted Radionuclide Therapy of Melanoma

Our project deals with a multimodal approach using a single fluorinated and iodinated melanin-targeting structure and offering both imaging (positron emission tomography (PET)/fluorine-18) and treatment (targeted radionuclide therapy/iodine-131) of melanoma. Six 6-iodoquinoxaline-2-carboxamide deriv...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-11, Vol.56 (21), p.8455-8467
Hauptverfasser:	Billaud, Emilie M. F, Rbah-Vidal, Latifa, Vidal, Aurélien, Besse, Sophie, Tarrit, Sébastien, Askienazy, Serge, Maisonial, Aurélie, Moins, Nicole, Madelmont, Jean-Claude, Miot-Noirault, Elisabeth, Chezal, Jean-Michel, Auzeloux, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical Sciences Disease Models, Animal Melanoma, Experimental - diagnostic imaging Melanoma, Experimental - radiotherapy Mice Mice, Inbred C57BL Molecular Structure Organic chemistry Positron-Emission Tomography Quinoxalines - chemical synthesis Quinoxalines - therapeutic use Radioactive Tracers Radiochemistry Tissue Distribution Tumor Cells, Cultured
Online-Zugang:	Volltext
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