N-Phenyl- N′-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl- N′-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?

A series of novel N-phenyl- N′-(2-chloroethyl)urea derivatives potentially mimicking the structure of combretastatin A-4 were synthesized and tested for their cell growth inhibition and their binding to the colchicine-binding site of β-tubulin. Compounds 2a, 3a, and 3b were found to inhibit cell gro...

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