Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: a large-scale biomarker-characterized monocenter cohort study (ClinAD)
Abstract Introduction The International Working Group recommended the Free and Cued Selective Reminding Test (FCSRT) as a sensitive detector of the amnesic syndrome of the hippocampal type in typical Alzheimer's disease (AD). But does it differentiate AD from other neurodegenerative diseases? M...
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| Veröffentlicht in: | Alzheimer's & dementia 2017-08, Vol.13 (8), p.913-923 |
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| creator | Teichmann, Marc Epelbaum, Stéphane Samri, Dalila Levy Nogueira, Marcel Michon, Agnès Hampel, Harald Lamari, Foudil Dubois, Bruno |
| description | Abstract Introduction The International Working Group recommended the Free and Cued Selective Reminding Test (FCSRT) as a sensitive detector of the amnesic syndrome of the hippocampal type in typical Alzheimer's disease (AD). But does it differentiate AD from other neurodegenerative diseases? Methods We assessed the FCSRT and cerebrospinal fluid (CSF) AD biomarkers in 992 cases. Experts, blinded to biomarker data, attributed in 650 cases a diagnosis of typical AD, frontotemporal dementia, posterior cortical atrophy, Lewy body disease, progressive supranuclear palsy, corticobasal syndrome, primary progressive aphasias, “subjective cognitive decline,” or depression. Results The FCSRT distinguished typical AD from all other conditions with a sensitivity of 100% and a specificity of 75%. Non-AD neurodegenerative diseases with positive AD CSF biomarkers (“atypical AD”) did not have lower FCSRT scores than those with negative biomarkers. Discussion The FCSRT is a reliable tool for diagnosing typical AD among various neurodegenerative diseases. At an individual level, however, its specificity is not absolute. Our findings also widen the spectrum of atypical AD to multiple neurodegenerative conditions. |
| doi_str_mv | 10.1016/j.jalz.2016.12.014 |
| format | Article |
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But does it differentiate AD from other neurodegenerative diseases? Methods We assessed the FCSRT and cerebrospinal fluid (CSF) AD biomarkers in 992 cases. Experts, blinded to biomarker data, attributed in 650 cases a diagnosis of typical AD, frontotemporal dementia, posterior cortical atrophy, Lewy body disease, progressive supranuclear palsy, corticobasal syndrome, primary progressive aphasias, “subjective cognitive decline,” or depression. Results The FCSRT distinguished typical AD from all other conditions with a sensitivity of 100% and a specificity of 75%. Non-AD neurodegenerative diseases with positive AD CSF biomarkers (“atypical AD”) did not have lower FCSRT scores than those with negative biomarkers. Discussion The FCSRT is a reliable tool for diagnosing typical AD among various neurodegenerative diseases. At an individual level, however, its specificity is not absolute. Our findings also widen the spectrum of atypical AD to multiple neurodegenerative conditions.</description><identifier>ISSN: 1552-5260</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1016/j.jalz.2016.12.014</identifier><identifier>PMID: 28222300</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Alzheimer's disease ; Assessment of memory disorders ; Biomarkers - cerebrospinal fluid ; Cohort Studies ; Cues ; Dementia ; Diagnosis, Differential ; Female ; Humans ; Life Sciences ; Male ; Memory ; Mental Status and Dementia Tests ; Neurodegenerative diseases ; Neurodegenerative Diseases - cerebrospinal fluid ; Neurodegenerative Diseases - diagnosis ; Neurodegenerative Diseases - psychology ; Neurology ; Neurons and Cognition ; Neuropsychological Tests ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>Alzheimer's & dementia, 2017-08, Vol.13 (8), p.913-923</ispartof><rights>The Alzheimer's Association</rights><rights>2017 the Alzheimer's Association</rights><rights>2017 The Alzheimer's Association</rights><rights>Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5474-84b55baa753f9e9a03de204720c7dfdc6d6e5eb462039ca23fdf95c8e285382e3</citedby><cites>FETCH-LOGICAL-c5474-84b55baa753f9e9a03de204720c7dfdc6d6e5eb462039ca23fdf95c8e285382e3</cites><orcidid>0000-0002-5104-2935 ; 0000-0003-0894-8982</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.jalz.2016.12.014$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.jalz.2016.12.014$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28222300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inria.hal.science/hal-01672862$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Teichmann, Marc</creatorcontrib><creatorcontrib>Epelbaum, Stéphane</creatorcontrib><creatorcontrib>Samri, Dalila</creatorcontrib><creatorcontrib>Levy Nogueira, Marcel</creatorcontrib><creatorcontrib>Michon, Agnès</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><creatorcontrib>Lamari, Foudil</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><title>Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: a large-scale biomarker-characterized monocenter cohort study (ClinAD)</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Abstract Introduction The International Working Group recommended the Free and Cued Selective Reminding Test (FCSRT) as a sensitive detector of the amnesic syndrome of the hippocampal type in typical Alzheimer's disease (AD). But does it differentiate AD from other neurodegenerative diseases? Methods We assessed the FCSRT and cerebrospinal fluid (CSF) AD biomarkers in 992 cases. Experts, blinded to biomarker data, attributed in 650 cases a diagnosis of typical AD, frontotemporal dementia, posterior cortical atrophy, Lewy body disease, progressive supranuclear palsy, corticobasal syndrome, primary progressive aphasias, “subjective cognitive decline,” or depression. Results The FCSRT distinguished typical AD from all other conditions with a sensitivity of 100% and a specificity of 75%. Non-AD neurodegenerative diseases with positive AD CSF biomarkers (“atypical AD”) did not have lower FCSRT scores than those with negative biomarkers. Discussion The FCSRT is a reliable tool for diagnosing typical AD among various neurodegenerative diseases. At an individual level, however, its specificity is not absolute. Our findings also widen the spectrum of atypical AD to multiple neurodegenerative conditions.</description><subject>Aged</subject><subject>Alzheimer's disease</subject><subject>Assessment of memory disorders</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Cohort Studies</subject><subject>Cues</subject><subject>Dementia</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Memory</subject><subject>Mental Status and Dementia Tests</subject><subject>Neurodegenerative diseases</subject><subject>Neurodegenerative Diseases - cerebrospinal fluid</subject><subject>Neurodegenerative Diseases - diagnosis</subject><subject>Neurodegenerative Diseases - psychology</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Neuropsychological Tests</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUs1u1DAQjhCIlsILcEC-0R6y2E6cH1QhRQulVCsh0XLhYnntya63jl3sZNHuiXfgpXgOngSnKT1wQFzs8eib7xvPN0nynOAZwaR4tZlthNnPaIxnhM4wyR8kh4QxmjJa1g_v4wIfJE9C2GCc44qwx8kBrSilGcaHyc8zD4CEVWg-gEKXYED2egvoE3TaKm1X6ApCj359_4GElIMXcoda51G_BqR024IH22th4kOsrAs6INeixuzXoDvwL8MtuYXBOwUrsODFLb_SAUSA8BoJZIRfQRqkMICW2nXCX4NP5VpEtR683sfOOmedjFLgkXRr53sU-kHt0PHcaNu8PXmaPGqFCfDs7j5KPp-9u5qfp4uP7z_Mm0UqWV7maZUvGVsKUbKsraEWOFNAcV5SLEvVKlmoAhgs84LirJaCZq1qayYroBXLKgrZUXIy8a6F4Tdex2Z33AnNz5sFH3PRjZJWBd2SiD2esDfefR3iGHmngwRjhAU3BE6qEtdVUZUjlE5Q6V0IHtp7boL56Dbf8NFtPrrNCY0yeSx6ccc_LDtQ9yV_7I2AZgJ80wZ2_0HJm8WXi4t4jDlCJ5HTiQPiVLcaPA9Sg5WgtI-7wpXT_-7xzV_lMhqmo9fXsIOwcYO30S9OeIgF_HLc2XFlSRk_QPIi-w3XRufw</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Teichmann, Marc</creator><creator>Epelbaum, Stéphane</creator><creator>Samri, Dalila</creator><creator>Levy Nogueira, Marcel</creator><creator>Michon, Agnès</creator><creator>Hampel, Harald</creator><creator>Lamari, Foudil</creator><creator>Dubois, Bruno</creator><general>Elsevier Inc</general><general>Alzheimer's Association / Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-5104-2935</orcidid><orcidid>https://orcid.org/0000-0003-0894-8982</orcidid></search><sort><creationdate>201708</creationdate><title>Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: a large-scale biomarker-characterized monocenter cohort study (ClinAD)</title><author>Teichmann, Marc ; Epelbaum, Stéphane ; Samri, Dalila ; Levy Nogueira, Marcel ; Michon, Agnès ; Hampel, Harald ; Lamari, Foudil ; Dubois, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5474-84b55baa753f9e9a03de204720c7dfdc6d6e5eb462039ca23fdf95c8e285382e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Alzheimer's disease</topic><topic>Assessment of memory disorders</topic><topic>Biomarkers - cerebrospinal fluid</topic><topic>Cohort Studies</topic><topic>Cues</topic><topic>Dementia</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Memory</topic><topic>Mental Status and Dementia Tests</topic><topic>Neurodegenerative diseases</topic><topic>Neurodegenerative Diseases - cerebrospinal fluid</topic><topic>Neurodegenerative Diseases - diagnosis</topic><topic>Neurodegenerative Diseases - psychology</topic><topic>Neurology</topic><topic>Neurons and Cognition</topic><topic>Neuropsychological Tests</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teichmann, Marc</creatorcontrib><creatorcontrib>Epelbaum, Stéphane</creatorcontrib><creatorcontrib>Samri, Dalila</creatorcontrib><creatorcontrib>Levy Nogueira, Marcel</creatorcontrib><creatorcontrib>Michon, Agnès</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><creatorcontrib>Lamari, Foudil</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teichmann, Marc</au><au>Epelbaum, Stéphane</au><au>Samri, Dalila</au><au>Levy Nogueira, Marcel</au><au>Michon, Agnès</au><au>Hampel, Harald</au><au>Lamari, Foudil</au><au>Dubois, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: a large-scale biomarker-characterized monocenter cohort study (ClinAD)</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2017-08</date><risdate>2017</risdate><volume>13</volume><issue>8</issue><spage>913</spage><epage>923</epage><pages>913-923</pages><issn>1552-5260</issn><eissn>1552-5279</eissn><abstract>Abstract Introduction The International Working Group recommended the Free and Cued Selective Reminding Test (FCSRT) as a sensitive detector of the amnesic syndrome of the hippocampal type in typical Alzheimer's disease (AD). But does it differentiate AD from other neurodegenerative diseases? Methods We assessed the FCSRT and cerebrospinal fluid (CSF) AD biomarkers in 992 cases. Experts, blinded to biomarker data, attributed in 650 cases a diagnosis of typical AD, frontotemporal dementia, posterior cortical atrophy, Lewy body disease, progressive supranuclear palsy, corticobasal syndrome, primary progressive aphasias, “subjective cognitive decline,” or depression. Results The FCSRT distinguished typical AD from all other conditions with a sensitivity of 100% and a specificity of 75%. Non-AD neurodegenerative diseases with positive AD CSF biomarkers (“atypical AD”) did not have lower FCSRT scores than those with negative biomarkers. Discussion The FCSRT is a reliable tool for diagnosing typical AD among various neurodegenerative diseases. At an individual level, however, its specificity is not absolute. Our findings also widen the spectrum of atypical AD to multiple neurodegenerative conditions.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28222300</pmid><doi>10.1016/j.jalz.2016.12.014</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5104-2935</orcidid><orcidid>https://orcid.org/0000-0003-0894-8982</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Alzheimer's disease Assessment of memory disorders Biomarkers - cerebrospinal fluid Cohort Studies Cues Dementia Diagnosis, Differential Female Humans Life Sciences Male Memory Mental Status and Dementia Tests Neurodegenerative diseases Neurodegenerative Diseases - cerebrospinal fluid Neurodegenerative Diseases - diagnosis Neurodegenerative Diseases - psychology Neurology Neurons and Cognition Neuropsychological Tests Reproducibility of Results Sensitivity and Specificity |
| title | Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: a large-scale biomarker-characterized monocenter cohort study (ClinAD) |
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