CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma

CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells, including glioblastoma (GBM) stem cells (GSC). However, the molecular and cellular functions of CD90 remain unclear. The function of CD90 in GBM was addressed using cellula...

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Veröffentlicht in:	Clinical cancer research 2017-12, Vol.23 (23), p.7360-7374
Hauptverfasser:	Avril, Tony, Etcheverry, Amandine, Pineau, Raphaël, Obacz, Joanna, Jegou, Gwénaële, Jouan, Florence, Le Reste, Pierre-Jean, Hatami, Masumeh, Colen, Rivka R, Carlson, Brett L, Decker, Paul A, Sarkaria, Jann N, Vauléon, Elodie, Chiforeanu, Dan Cristian, Clavreul, Anne, Mosser, Jean, Chevet, Eric, Quillien, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Adult Aged Animal models Animals Antineoplastic Agents - pharmacology Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Cancer CD90 antigen Cell Line, Tumor Cell migration Cell Movement - genetics Dasatinib - pharmacology Disease-Free Survival Experimental design Female Gene expression Glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Glycoproteins Humans Invasiveness Life Sciences Magnetic resonance imaging Male Mathematical models Mice Middle Aged Neoplastic Stem Cells - metabolism Neurobiology Neurons and Cognition Patients Pharmaceutical sciences Pharmacology Prognosis Signaling src-Family Kinases - genetics src-Family Kinases - metabolism Stem cell transplantation Stem cells Thy-1 Antigens - genetics Thy-1 Antigens - metabolism Xenograft Model Antitumor Assays Xenografts
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