In vitro cell transformation induced by synthetic amorphous silica nanoparticles

•The Bhas 42 cell transformation assay is suitable for particle-type substances.•Four different silica nanoparticles induced cell transformation in Bhas 42 cells.•The four silica nanoparticles act as tumor-promoter substances in the Bhas 42 model. Synthetic amorphous silica nanoparticles (SAS) are a...

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Veröffentlicht in:	Mutation research 2017-11, Vol.823, p.22-27
Hauptverfasser:	Fontana, Caroline, Kirsch, Anaïs, Seidel, Carole, Marpeaux, Léa, Darne, Christian, Gaté, Laurent, Remy, Aurélie, Guichard, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BALB 3T3 Cells Bhas 42 Carcinogenesis - drug effects Carcinogenesis - metabolism Carcinogenicity Tests Carcinogens - toxicity Cell transformation assay Cell Transformation, Neoplastic - chemically induced Cell Transformation, Neoplastic - metabolism Chemical engineering Chemical Sciences Engineering Sciences Genes, ras Life Sciences Mice Micro and nanotechnologies Microelectronics Nanomaterial Nanoparticles - toxicity Particle Size Silicon Dioxide - toxicity Synthetic amorphous silica Toxicology
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