Refining uptake and depuration constants for fluoroalkyl chemicals in Chironomus riparius larvae on the basis of experimental results and modelling
The aims of this study were to determine depuration rates for a range of per- and polyfluoroalkyl substances (PFASs) using Chironomus riparius, and to test a concentration-dependency hypothesis for the long-chain perfluorotridecanoic acid (PFTrDA) for this species. Midge larvae were exposed to field...
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| Veröffentlicht in: | Ecotoxicology and environmental safety 2018-03, Vol.149, p.284-290 |
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| creator | Bertin, Delphine Ferrari, Benoît J.D. Labadie, Pierre Sapin, Alexandre Da Silva Avelar, Débora Beaudouin, Rémy Péry, Alexandre Garric, Jeanne Budzinski, Hélène Babut, Marc |
| description | The aims of this study were to determine depuration rates for a range of per- and polyfluoroalkyl substances (PFASs) using Chironomus riparius, and to test a concentration-dependency hypothesis for the long-chain perfluorotridecanoic acid (PFTrDA) for this species. Midge larvae were exposed to field sediments collected downstream of a fluorotelomer plant, and to the same sediment spiked with PFTrDA. Elimination kinetics results indicated complete elimination of all PFASs by chironomids after 42h. These data were used to develop two PFTrDA bioaccumulation models accounting for chironomid growth and for compound concentration dependency or not. There was much better agreement between observed and simulated data under the concentration-dependency hypothesis than under the alternative one (passive diffusion). The PFTrDA uptake rate derived from the concentration-dependency model equaled 0.013 ± 0.008gocgwwh−1, and the depuration rate 0.032 ± 0.009h−1.
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•Chironomids were exposed to sediment contaminated by fluoro-alkyl substances.•For all compounds, nearly complete elimination from tissues was achieved in 42h.•Modelling shows that PFTrDA uptake is concentration-dependent. |
| doi_str_mv | 10.1016/j.ecoenv.2017.12.011 |
| format | Article |
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[Display omitted]
•Chironomids were exposed to sediment contaminated by fluoro-alkyl substances.•For all compounds, nearly complete elimination from tissues was achieved in 42h.•Modelling shows that PFTrDA uptake is concentration-dependent.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1016/j.ecoenv.2017.12.011</identifier><identifier>PMID: 29258051</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Bioaccumulation ; Chironomidae - metabolism ; Chironomus riparius ; Concentration-dependency ; Dose-Response Relationship, Drug ; Fluorocarbons - metabolism ; Geologic Sediments - chemistry ; Larva - metabolism ; Life Sciences ; Models, Theoretical ; Per- and polyfluoroalkyl substances ; Perfluorotridecanoic acid ; Uptake rate ; Water Pollutants, Chemical - metabolism</subject><ispartof>Ecotoxicology and environmental safety, 2018-03, Vol.149, p.284-290</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Attribution - ShareAlike</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-18bfd8aa71e44e8d6673d5491a796f0a190a28df9e37c2ee92f95369028502b43</citedby><cites>FETCH-LOGICAL-c479t-18bfd8aa71e44e8d6673d5491a796f0a190a28df9e37c2ee92f95369028502b43</cites><orcidid>0000-0002-2855-1571 ; 0000-0001-7184-6327 ; 0000-0001-5637-072X ; 0000-0002-6919-1314 ; 0000-0001-5282-9011 ; 0000-0003-1028-9154</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ecoenv.2017.12.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29258051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01666918$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bertin, Delphine</creatorcontrib><creatorcontrib>Ferrari, Benoît J.D.</creatorcontrib><creatorcontrib>Labadie, Pierre</creatorcontrib><creatorcontrib>Sapin, Alexandre</creatorcontrib><creatorcontrib>Da Silva Avelar, Débora</creatorcontrib><creatorcontrib>Beaudouin, Rémy</creatorcontrib><creatorcontrib>Péry, Alexandre</creatorcontrib><creatorcontrib>Garric, Jeanne</creatorcontrib><creatorcontrib>Budzinski, Hélène</creatorcontrib><creatorcontrib>Babut, Marc</creatorcontrib><title>Refining uptake and depuration constants for fluoroalkyl chemicals in Chironomus riparius larvae on the basis of experimental results and modelling</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>The aims of this study were to determine depuration rates for a range of per- and polyfluoroalkyl substances (PFASs) using Chironomus riparius, and to test a concentration-dependency hypothesis for the long-chain perfluorotridecanoic acid (PFTrDA) for this species. Midge larvae were exposed to field sediments collected downstream of a fluorotelomer plant, and to the same sediment spiked with PFTrDA. Elimination kinetics results indicated complete elimination of all PFASs by chironomids after 42h. These data were used to develop two PFTrDA bioaccumulation models accounting for chironomid growth and for compound concentration dependency or not. There was much better agreement between observed and simulated data under the concentration-dependency hypothesis than under the alternative one (passive diffusion). The PFTrDA uptake rate derived from the concentration-dependency model equaled 0.013 ± 0.008gocgwwh−1, and the depuration rate 0.032 ± 0.009h−1.
[Display omitted]
•Chironomids were exposed to sediment contaminated by fluoro-alkyl substances.•For all compounds, nearly complete elimination from tissues was achieved in 42h.•Modelling shows that PFTrDA uptake is concentration-dependent.</description><subject>Animals</subject><subject>Bioaccumulation</subject><subject>Chironomidae - metabolism</subject><subject>Chironomus riparius</subject><subject>Concentration-dependency</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fluorocarbons - metabolism</subject><subject>Geologic Sediments - chemistry</subject><subject>Larva - metabolism</subject><subject>Life Sciences</subject><subject>Models, Theoretical</subject><subject>Per- and polyfluoroalkyl substances</subject><subject>Perfluorotridecanoic acid</subject><subject>Uptake rate</subject><subject>Water Pollutants, Chemical - metabolism</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhQtRnJ7RNxDJ1kWVuanfbIShGR2hQRBdh3RyY6cnlRRJVTPzHL6wKUpn6SqXcL5zf05RvANaAYXu47lCFdBfKkahr4BVFOBFsQPKackaaF4WOwpNX3Yt1FfFdUpnSmlN2_Z1ccU4awfawq74_R2N9db_Iss0ywck0muicVqinG3wRAWfZunnREyIxLglxCDdw5Mj6oSjVdIlYj3Zn2wMPoxLItFOMtpcOBkvEkk2mU9IjjLZRIIh-DhhtCP6WToSMS0um69dx6DRuTzKm-KVyb749u97U_z8fPdjf18evn35ur89lKrp-VzCcDR6kLIHbBocdNf1tW4bDrLnnaESOJVs0IZj3SuGyJnhbd1xyoaWsmNT3xQfNt-TdGLKM8n4JIK04v72INa_fOau4zBcIGubTatiSCmieQaAijUPcRZbHmLNQwDL9Iq937BpOY6on6F_AWTBp02AedGLxSiSsugVahtRzUIH-_8OfwCPVqDU</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Bertin, Delphine</creator><creator>Ferrari, Benoît J.D.</creator><creator>Labadie, Pierre</creator><creator>Sapin, Alexandre</creator><creator>Da Silva Avelar, Débora</creator><creator>Beaudouin, Rémy</creator><creator>Péry, Alexandre</creator><creator>Garric, Jeanne</creator><creator>Budzinski, Hélène</creator><creator>Babut, Marc</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-2855-1571</orcidid><orcidid>https://orcid.org/0000-0001-7184-6327</orcidid><orcidid>https://orcid.org/0000-0001-5637-072X</orcidid><orcidid>https://orcid.org/0000-0002-6919-1314</orcidid><orcidid>https://orcid.org/0000-0001-5282-9011</orcidid><orcidid>https://orcid.org/0000-0003-1028-9154</orcidid></search><sort><creationdate>20180301</creationdate><title>Refining uptake and depuration constants for fluoroalkyl chemicals in Chironomus riparius larvae on the basis of experimental results and modelling</title><author>Bertin, Delphine ; Ferrari, Benoît J.D. ; Labadie, Pierre ; Sapin, Alexandre ; Da Silva Avelar, Débora ; Beaudouin, Rémy ; Péry, Alexandre ; Garric, Jeanne ; Budzinski, Hélène ; Babut, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-18bfd8aa71e44e8d6673d5491a796f0a190a28df9e37c2ee92f95369028502b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Bioaccumulation</topic><topic>Chironomidae - metabolism</topic><topic>Chironomus riparius</topic><topic>Concentration-dependency</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fluorocarbons - metabolism</topic><topic>Geologic Sediments - chemistry</topic><topic>Larva - metabolism</topic><topic>Life Sciences</topic><topic>Models, Theoretical</topic><topic>Per- and polyfluoroalkyl substances</topic><topic>Perfluorotridecanoic acid</topic><topic>Uptake rate</topic><topic>Water Pollutants, Chemical - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bertin, Delphine</creatorcontrib><creatorcontrib>Ferrari, Benoît J.D.</creatorcontrib><creatorcontrib>Labadie, Pierre</creatorcontrib><creatorcontrib>Sapin, Alexandre</creatorcontrib><creatorcontrib>Da Silva Avelar, Débora</creatorcontrib><creatorcontrib>Beaudouin, Rémy</creatorcontrib><creatorcontrib>Péry, Alexandre</creatorcontrib><creatorcontrib>Garric, Jeanne</creatorcontrib><creatorcontrib>Budzinski, Hélène</creatorcontrib><creatorcontrib>Babut, Marc</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bertin, Delphine</au><au>Ferrari, Benoît J.D.</au><au>Labadie, Pierre</au><au>Sapin, Alexandre</au><au>Da Silva Avelar, Débora</au><au>Beaudouin, Rémy</au><au>Péry, Alexandre</au><au>Garric, Jeanne</au><au>Budzinski, Hélène</au><au>Babut, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Refining uptake and depuration constants for fluoroalkyl chemicals in Chironomus riparius larvae on the basis of experimental results and modelling</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>149</volume><spage>284</spage><epage>290</epage><pages>284-290</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><abstract>The aims of this study were to determine depuration rates for a range of per- and polyfluoroalkyl substances (PFASs) using Chironomus riparius, and to test a concentration-dependency hypothesis for the long-chain perfluorotridecanoic acid (PFTrDA) for this species. Midge larvae were exposed to field sediments collected downstream of a fluorotelomer plant, and to the same sediment spiked with PFTrDA. Elimination kinetics results indicated complete elimination of all PFASs by chironomids after 42h. These data were used to develop two PFTrDA bioaccumulation models accounting for chironomid growth and for compound concentration dependency or not. There was much better agreement between observed and simulated data under the concentration-dependency hypothesis than under the alternative one (passive diffusion). The PFTrDA uptake rate derived from the concentration-dependency model equaled 0.013 ± 0.008gocgwwh−1, and the depuration rate 0.032 ± 0.009h−1.
[Display omitted]
•Chironomids were exposed to sediment contaminated by fluoro-alkyl substances.•For all compounds, nearly complete elimination from tissues was achieved in 42h.•Modelling shows that PFTrDA uptake is concentration-dependent.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>29258051</pmid><doi>10.1016/j.ecoenv.2017.12.011</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2855-1571</orcidid><orcidid>https://orcid.org/0000-0001-7184-6327</orcidid><orcidid>https://orcid.org/0000-0001-5637-072X</orcidid><orcidid>https://orcid.org/0000-0002-6919-1314</orcidid><orcidid>https://orcid.org/0000-0001-5282-9011</orcidid><orcidid>https://orcid.org/0000-0003-1028-9154</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Ecotoxicology and environmental safety, 2018-03, Vol.149, p.284-290 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Bioaccumulation Chironomidae - metabolism Chironomus riparius Concentration-dependency Dose-Response Relationship, Drug Fluorocarbons - metabolism Geologic Sediments - chemistry Larva - metabolism Life Sciences Models, Theoretical Per- and polyfluoroalkyl substances Perfluorotridecanoic acid Uptake rate Water Pollutants, Chemical - metabolism |
| title | Refining uptake and depuration constants for fluoroalkyl chemicals in Chironomus riparius larvae on the basis of experimental results and modelling |
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