Transformed Waldenström macroglobulinaemia: clinical presentation and outcome. A multi‐institutional retrospective study of 77 cases from the French Innovative Leukemia Organization (FILO)

Summary Histological transformation (HT) to diffuse large B‐cell lymphoma (DLBCL) is a rare and poorly reported complication of Waldenström macroglobulinaemia (WM). We performed a retrospective study of 77 WM patients with biopsy‐proven transformation to DLBCL. The median time from WM diagnosis to H...

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Veröffentlicht in:	British journal of haematology 2017-11, Vol.179 (3), p.439-448
Hauptverfasser:	Durot, Eric, Tomowiak, Cécile, Michallet, Anne‐Sophie, Dupuis, Jehan, Hivert, Bénédicte, Leprêtre, Stéphane, Toussaint, Elise, Godet, Sophie, Merabet, Fatiha, Van Den Neste, Eric, Ivanoff, Sarah, Roussel, Xavier, Zini, Jean‐Marc, Regny, Caroline, Lemal, Richard, Sutton, Laurent, Perrot, Aurore, Le Dû, Katell, Kanagaratnam, Lukshe, Morel, Pierre, Leblond, Véronique, Delmer, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Murine-Derived - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use B-cell lymphoma Biomarkers, Tumor - blood Biopsy Cell Transformation, Neoplastic - pathology Central nervous system chemoimmunotherapy Cyclophosphamide Cyclophosphamide - therapeutic use diffuse large B‐cell lymphoma Doxorubicin Doxorubicin - therapeutic use Emission analysis extranodal involvement Female Fluorodeoxyglucose F18 Genetic transformation Hematology histological transformation Human health and pathology Humans L-Lactate Dehydrogenase - blood Leukemia Life Sciences Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - diagnostic imaging Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - pathology Male Middle Aged Monoclonal antibodies Positron emission tomography Positron-Emission Tomography - methods Prednisone Prednisone - therapeutic use Prognosis Retrospective Studies Risk Factors Rituximab Survival Analysis Targeted cancer therapy Tomography, X-Ray Computed Treatment Outcome Vincristine Vincristine - therapeutic use Waldenstrom Macroglobulinemia - diagnostic imaging Waldenstrom Macroglobulinemia - pathology Waldenström macroglobulinaemia
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