Cytotoxicity assessment of heparin nanoparticles in NR8383 macrophages

The bioavailability of low molecular weight heparin (LMWH) has been increased by encapsulation in nanoparticles. As a complement to these results, the cytotoxicity and apoptosis induced by LMWH nanoparticles prepared by two methods [nanoprecipitation (NP) and double emulsion (DE)] using Eudragit ® R...

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Veröffentlicht in:	International journal of pharmaceutics 2010-08, Vol.396 (1), p.156-165
Hauptverfasser:	Eidi, H., Joubert, O., Attik, G., Duval, R.E., Bottin, M.C., Hamouia, A., Maincent, P., Rihn, B.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Acrylic Resins - toxicity Animals Anticoagulants - chemistry Apoptosis Apoptosis - drug effects Bacteriology Biological and medical sciences Caspases - metabolism Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Chemistry, Pharmaceutical Cytotoxicity Dose-Response Relationship, Drug Double emulsion Drug Carriers Drug Compounding Enzyme Activation General pharmacology Heparin, Low-Molecular-Weight - chemistry Inhibitory Concentration 50 Life Sciences Macrophages Macrophages, Alveolar - drug effects Macrophages, Alveolar - enzymology Macrophages, Alveolar - pathology Medical sciences Medication Microbiology and Parasitology Nanoparticles Nanoprecipitation Nanotechnology Particle Size Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters - chemistry Polyesters - toxicity Rats Technology, Pharmaceutical - methods Time Factors Virology
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